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Merck Sharp & Dohme Corporation

5325 Old Oxford Rd, Durham, NC 27712

LIKELY ACTIVELAST SEEN IN FEDERAL DATA JUN 2026 · 3 SOURCES

Operating signal within 24 months, or from a single source.

WARN ACT NOTICE FILED WITH THE STATE
  • Layoff notice effective MAY 1, 2026 · 147 employees · filed FEB 24, 2026 · Layoff — recorded; a layoff does not change the status

Notices filed with the state under the federal WARN Act, as the state publishes them, collected by the WARN Act notices feed (CC BY 4.0). A notice records what the employer told the state; it is not by itself proof that the plant closed.

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What they make

Medicinal and Botanical Manufacturing325411

Products

Sold by MERCK SHARP & DOHME LLC · 54
aprepitant · Bacillus Calmette-Guerin · Bacillus Calmette-Guerin Substrain Tice Live Antigen · belzutifan · bezlotoxumab · Caspofungin Acetate · ceftolozane and tazobactam · Clesrovimab · doravirine · Doravirine, Islatravir · doravirine, lamivudine, and tenofovir disoproxil fumarate · Drugs And Biologicals · elbasvir and grazoprevir · ensifentrine · ertapenem sodium · ertugliflozin · ertugliflozin and metformin hydrochloride · ertugliflozin and sitagliptin · Fidaxomicin · Fosaprepitant Dimeglumine · Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) · hepatitis A vaccine, inactivated · Hepatitis B Vaccine (Recombinant) · Human Papillomavirus 9-valent Vaccine, Recombinant · Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant · imipenem and cilastatin sodium · imipenem anhydrous, cilastatin, and relebactam anhydrous · Ivermectin · Latrodectus mactans · Letermovir · Lipfendra · measles, mumps, and rubella virus vaccine live · Measles, Mumps, Rubella and Varicella Virus Vaccine Live · Medical And Surgical Instruments, Equipment, And Supplies · pembrolizumab · pembrolizumab and berahyaluronidase alfa-pmph · Pneumococcal 15-valent Conjugate Vaccine CRM197 Protein adsorbed · Pneumococcal 21-valent Conjugate Vaccine · pneumococcal vaccine polyvalent · Posaconazole · Raltegravir · Rotavirus Vaccine, Live, Oral, Pentavalent · sitagliptin · Sitagliptin and Metformin Hydrochloride · Sotatercept-Csrk · Sterile Water · Sugammadex · suvorexant · tedizolid phosphate · Temozolomide · Varicella Virus Vaccine Live · vericiguat · vorinostat · Zaire Ebolavirus (Strain Kikwit-95) Envelope Glycoprotein

Recorded against the company rather than this address. Federal award and drug records name the company, not the plant, so we cannot say which of its sites makes these.

Where these came from
52 from FDA drug listing · Federal registry
FDA drug listing, labeler Merck Sharp & Dohme LLC, NDC 0006-0081. A labeler markets the product; it may not manufacture it.
2 from usaspending_psc · Federal registry
Supplied under federal award W911QY21C0031 (2021-06-07), PSC . An award shows what the government bought from this company; it does not establish which of its sites made it.

Open positions

Openings read from Merck Sharp & Dohme LLC’s own job boards on Phenom and Workday, last checked OCT 23, 2026. FactoryRegistry does not host applications — each title opens the posting where the company published it.

OTHER OPENINGS AT MERCK SHARP & DOHME LLC, NOT MATCHED TO THIS PLANT

1,324 more on the company’s board

Where it is

36.10979, -78.84122 · CENSUS TIGER
COUNTY
METRO AREA
ON GOOGLE MAPS

Other plants nearby

FacilityCityIndustryStatusDistance
Durham, NC FacilityDurhamBiological Product (except Diagnostic) Manufacturing
325414
 LIKELY ACTIVE0.4 KM
BiomerieuxDurhamIn-Vitro Diagnostic Substance Manufacturing
325413
 LIKELY ACTIVE1.6 KM
129163 - Biomerieux, INC.Eno ValleyIn-Vitro Diagnostic Substance Manufacturing
325413
 LIKELY ACTIVE1.6 KM
Merck TeknikaDurhamBiological Product (except Diagnostic) Manufacturing
325414
 ACTIVE1.8 KM
Merck Teknika FacilityDurhamBiological Product (except Diagnostic) Manufacturing
325414
 LIKELY ACTIVE2.4 KM

Every listed plant in Durham County

Also at this address

No other federal record shares this street address.

Where this record comes from

3 sources hold this plant, and 7 fields on this page come from them. Each line is one agency’s own record of it: the identifier it is filed under, whether that record shows the plant operating or only that it exists, and when the register first and last saw it there.

EPA cross-references this facility in AIR, AIRS/AFS, BR, OSHA-OIS, RCRAINFO · EPA site type STATIONARY.

  • EPA ECHO compliance recordsOPERATING
    first seen JUN 2026 · last seen JUN 2026
  • State WARN plant-closing and layoff noticesEXISTENCE
    first seen MAY 2026 · last seen MAY 2026
  • EPA Facility Registry ServiceEXISTENCE
    Record 110031359526 · first seen JAN 2015 · last seen JUN 2017

ALSO RECORDED ASMERCK SHARP & DOHME LLC

IN DURHAM COUNTY59 other plants share this one’s industry (Pharmaceutical and Medicine Manufacturing, NAICS 3254); 16 of them have a size band on record.

What each source says

Every field below, as each source filed it. The value this page shows is marked; where the sources disagree, the field says so. Status is computed from independent sources; nothing here is self-reported unless marked Claimed.

Name
EPA: MERCK SHARP & DOHME CORPORATION · OCT 2026
Street address
EPA: 5325 OLD OXFORD RD · OCT 2026
City
EPA: DURHAM · OCT 2026
State
EPA: NC · OCT 2026
County (FIPS code)
EPA: 37063 · OCT 2026
Coordinates
EPA: 36.10979,-78.84122 · OCT 2026
Hazardous waste generator (RCRA)
EPA ECHO: LQG · OCT 2026

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