| TMTulip Molded Plastics LLC | Niagara Falls, NY | Chemical Manufacturing325991 | 20–99 | ◐ LIKELY ACTIVE |
| UNUpstate Niagara Cooperative INC | Buffalo, NY | Food Manufacturing311511 | 100–499 | ◐ LIKELY ACTIVE |
| WTWelded Tube USA INC | Lackawanna, NY | Primary Metal Manufacturing331111 | 100–499 | ◐ LIKELY ACTIVE |
Whiting Door Manufacturing CORP Bloomingdale Facility | Akron, NY | Fabricated Metal Product Manufacturing332611 | 20–99 | ◐ LIKELY ACTIVE |
| APArmstrong Pumps | North Tonawanda, NY | Fabricated Metal Product Manufacturing332912 | 100–499 | ◐ LIKELY ACTIVE |
| BWBuffalo Wire Works CO | Buffalo, NY | Fabricated Metal Product Manufacturing332618 | 100–499 | ◐ LIKELY ACTIVE |
| CPConfer Plastics INC | North Tonawanda, NY | Plastics and Rubber Products Manufacturing326199 | 100–499 | ◐ LIKELY ACTIVE |
| CCCrosby Company | Buffalo, NY | Fabricated Metal Product Manufacturing332116 | 20–99 | ◐ LIKELY ACTIVE |
| DMDerrick Manufacturing CORP | Buffalo, NY | Machinery Manufacturing333131 | — | ◐ LIKELY ACTIVE |
| DSDiamond Saw Works,inc. | Chaffee, NY | Fabricated Metal Product Manufacturing332213 | 20–99 | ◐ LIKELY ACTIVE |
| EIE I Dupont De Nemours - Yerkes Plant | Buffalo, NY | Chemical Manufacturing325211 | — | ◐ LIKELY ACTIVE |
Electrical Energy Limited, LLC | Barker, NY | Electrical Equipment, Appliance & Component Manufacturing335999 | — | ◐ LIKELY ACTIVE |
| EIElmar Industries INC | Depew, NY | Machinery Manufacturing333241 | 20–99 | ◐ LIKELY ACTIVE |
| EMENHANCED MACHINE LLC dba ENHANCED TOOL | Amherst, NY | Fabricated Metal Product Manufacturing332710 | 1–19 | ▲ REPORTED CLOSED |
| EME&r Machine INC | Lockport, NY | Fabricated Metal Product Manufacturing332710 | 20–99 | ◐ LIKELY ACTIVE |
| FFmc | Middleport, NY | Chemical Manufacturing325320 | — | ◐ LIKELY ACTIVE |
| FCFmc Corporation | Tonawanda, NY | Chemical Manufacturing325180 | — | ◐ LIKELY ACTIVE |
| GCGoodyear Chem Plant | Niagara Falls, NY | Chemical Manufacturing325199 | — | ◐ LIKELY ACTIVE |
| HHHdm Hydraulics LLC | Tonawanda, NY | Machinery Manufacturing333995 | 100–499 | ◐ LIKELY ACTIVE |
| IIInternational Imaging | Amherst, NY | Miscellaneous Manufacturing339940 | — | ◐ LIKELY ACTIVE |
| IBIslechem By Aceto | Grand Island, NY | Chemical Manufacturing325181 | — | ◐ LIKELY ACTIVE |
| IIIsochem INC | Lockport, NY | Chemical Manufacturing325181 | — | ◐ LIKELY ACTIVE |
| MBMayer Brothers Apple Products INC. | Barker, NY | Food Manufacturing311421 | — | ◐ LIKELY ACTIVE |
| MCMod-pac CORP | Buffalo, NY | Paper Manufacturing322212 | 100–499 | ◐ LIKELY ACTIVE |
| NTNiagara Transformer CORP | Buffalo, NY | Electrical Equipment, Appliance & Component Manufacturing335311 | 20–99 | ◐ LIKELY ACTIVE |
| OCOlin Chlor Alkali Products | Niagara Falls, NY | Chemical Manufacturing325180 | — | ◐ LIKELY ACTIVE |
| PCPlesh Contract Packaging | Buffalo, NY | Chemical Manufacturing325611 | 20–99 | ◐ LIKELY ACTIVE |
| PAPrecision Abrasives CORP | Orchard Park, NY | Nonmetallic Mineral Product Manufacturing327910 | 20–99 | ◐ LIKELY ACTIVE |
| PRPrince Rubber & Plastics CO INC | Buffalo, NY | Plastics and Rubber Products Manufacturing326291 | 20–99 | ◐ LIKELY ACTIVE |
| RIReichert INC | Depew, NY | Machinery Manufacturing333314 | — | ◐ LIKELY ACTIVE |
| RERepublic Engineered Products INC | Blasdell, NY | Primary Metal Manufacturing331110 | — | ◐ LIKELY ACTIVE |
| RMRigidized Metals CORP | Buffalo, NY | Primary Metal Manufacturing331491 | 20–99 | ◐ LIKELY ACTIVE |
| SSSafety-kleen Systems INC Buffalo Oil Recovery Facility | Buffalo, NY | Petroleum and Coal Products Manufacturing324191 | — | ◐ LIKELY ACTIVE |
| SNSaint-gobain Niagara Falls | Niagara Falls, NY | Textile Mills313311 | — | ◐ LIKELY ACTIVE |
| SIServotronics INC | Elma, NY | Fabricated Metal Product Manufacturing332911 | 100–499 | ◐ LIKELY ACTIVE |
| SPShuman Plastics INC | Depew, NY | Chemical Manufacturing325211 | 20–99 | ◐ LIKELY ACTIVE |
| STStellar Technology | Amherst, NY | Computer and Electronic Product Manufacturing334519 | 100–499 | ◐ LIKELY ACTIVE |
| SRSumitomo Rubber Usa, LLC (fmr Goodyear Dunlop Tire North America Ltd) | Tonawanda, NY | Plastics and Rubber Products Manufacturing326211 | — | ◐ LIKELY ACTIVE |
Trek, INC. | Lockport, NY | Computer and Electronic Product Manufacturing334515 | — | ◐ LIKELY ACTIVE |
| WBWatson Bowman Acme CORP | Amherst, NY | Fabricated Metal Product Manufacturing332312 | 20–99 | ◐ LIKELY ACTIVE |
| BOBattenfeld-grease & Oil Corporation | North Tonowanda, NY | Petroleum and Coal Products Manufacturing324191 | — | ◐ LIKELY ACTIVE |
| BABridgestone Apm Foaming Company America | Sanborn, NY | Plastics and Rubber Products Manufacturing326150 | — | ◐ LIKELY ACTIVE |
| FCFlame Control Coatings INC | Niagara Falls, NY | Chemical Manufacturing325510 | — | ◐ LIKELY ACTIVE |
| GCGm Components Holdings LLC | Lockport, NY | Machinery Manufacturing333415 | — | ◐ LIKELY ACTIVE |
| MSMetaullics Systems Division of Pyrotek INC | Sanborn, NY | Electrical Equipment, Appliance & Component Manufacturing335991 | — | ◐ LIKELY ACTIVE |
| NRNiagara Refining LLC | Depew, NY | Primary Metal Manufacturing331314 | — | ◐ LIKELY ACTIVE |
| TTesla | Buffalo, NY | Computer and Electronic Product Manufacturing334413 | — | ◐ LIKELY ACTIVE |
| TETonawanda Engine Plant | Tonawanda, NY | Machinery Manufacturing333618 | — | ◐ LIKELY ACTIVE |
| UBUnicell Body Company INC | Buffalo, NY | Transportation Equipment Manufacturing336110 | — | ◐ LIKELY ACTIVE |
| UNUpstate Niagara Cooperative INC Culture Facility | West Seneca, NY | Food Manufacturing311511 | — | ◐ LIKELY ACTIVE |