| PAPatheon API, Inc. | Florence, SC | Chemical Manufacturing325411 | 100–499 | ◐ LIKELY ACTIVE |
| PJPxxiii Jv, LLC | Florence, SC | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| RBRBC Bearings | Hartsville, SC | Fabricated Metal Product Manufacturing332991 | 100–499 | ◐ LIKELY ACTIVE |
| SDSC264 Darlington (Dixie) | Darlington, SC | Paper Manufacturing322219 | 500+ | ◐ LIKELY ACTIVE |
 Signode Industrial Group- Darlington, SC | Darlington, SC | Plastics and Rubber Products Manufacturing326199 | 20–99 | ◐ LIKELY ACTIVE |
| SLSigns Limited of Lake City, INC. | Lake City, SC | Miscellaneous Manufacturing339950 | — | ◐ LIKELY ACTIVE |
| SCSouth Carolina Manufacturing | Timmonsville, SC | Transportation Equipment Manufacturing336999 | 500+ | ◐ LIKELY ACTIVE |
 SteelFab Inc Florence | Florence, SC | Fabricated Metal Product Manufacturing332312 | 100–499 | ◐ LIKELY ACTIVE |
| SHStraw Hat Distillery, LLC | Florence, SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| URUnited Refrigeration INC | Florence, SC | Machinery Manufacturing333415 | — | ◐ LIKELY ACTIVE |
| ALAluminum Ladder Company | Florence, SC | Fabricated Metal Product Manufacturing332999 | — | ◇ UNVERIFIED |
| ACApac Carolina:plant 422 Florence | Florence, SC | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| ACAsman Cakes 3, LLC | Florence, SC | Food Manufacturing311811 | — | ◇ UNVERIFIED |
| ATAtlantic Tooling and Fabricating CO INC | Florence, SC | Machinery Manufacturing333514 | — | ◇ UNVERIFIED |
| BOBest One Tire | Timmonsville, SC | Plastics and Rubber Products Manufacturing326212 | — | ◇ UNVERIFIED |
| CPCalder Powder Coaters INC | Darlington, SC | Fabricated Metal Product Manufacturing332812 | — | ◇ UNVERIFIED |
| CACommercial and Industrial Piping | Quinby, SC | Fabricated Metal Product Manufacturing332996 | — | ◇ UNVERIFIED |
| CPCon-e-co Portable 913 | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| CHCrown Holdings | Effingham, SC | Fabricated Metal Product Manufacturing332431 | — | ◇ UNVERIFIED |
| DSDarlington Shredding | Darlington, SC | Primary Metal Manufacturing331492 | — | ◇ UNVERIFIED |
| ECEast Coast Erosion Holdings LLC | Lake City, SC | Miscellaneous Manufacturing339999 | — | ◇ UNVERIFIED |
| FCFlorence Concrete Products INC | Florence, SC | Nonmetallic Mineral Product Manufacturing327390 | — | ◇ UNVERIFIED |
| FIFrazier Industrial Company | Lamar, SC | Furniture and Related Product Manufacturing337127 | — | ◇ UNVERIFIED |
| FBFreemans Bakery of Florence LLC | Florence, SC | Food Manufacturing311811 | — | ◇ UNVERIFIED |
| GDGmack Designs LLC | Lake City, SC | Textile Product Mills314999 | — | ◇ UNVERIFIED |
| HWHandcraft Woodwork and Design | Timmonsville, SC | Furniture and Related Product Manufacturing337110 | — | ◇ UNVERIFIED |
| HPHilex Poly Company LLC | Hartsville, SC | Plastics and Rubber Products Manufacturing326111 | — | ◇ UNVERIFIED |
| ISIntegrated Systems INC | Darlington, SC | Machinery Manufacturing333518 | — | ◇ UNVERIFIED |
| IHIron Hills LLC | Florence, SC | Wood Product Manufacturing321992 | — | ◇ UNVERIFIED |
| IAItw Angleboard | Darlington, SC | Paper Manufacturing322130 | — | ◇ UNVERIFIED |
| JSJaymac Sports Products LLC | Florence, SC | Textile Product Mills314999 | — | ◇ UNVERIFIED |
| JIJbe INC | Hartsville, SC | Miscellaneous Manufacturing339999 | — | ◇ UNVERIFIED |
| LCLane Construction Plant 23 | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| LZLa - Z - Boy Incorporated | Florence, SC | Furniture and Related Product Manufacturing337110 | — | ◇ UNVERIFIED |
| LOLive Oak Metal Works & Supply, LLC | Florence, SC | Primary Metal Manufacturing331221 | — | ◇ UNVERIFIED |
| NSNew South Lumber Company INC | Darlington, SC | Wood Product Manufacturing321113 | — | ◇ UNVERIFIED |
| NBNiagara Bottling, LLC | Florence, SC | Beverage and Tobacco Product Manufacturing312112 | — | ◇ UNVERIFIED |
| PPPalmetto Paving:florence | Florence, SC | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| PAPatheon Api Services INC | Florence, SC | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| PDPee Dee Tank Company of South Carolina LLC | Florence, SC | Fabricated Metal Product Manufacturing332313 | — | ◇ UNVERIFIED |
| PIPfc INC | Hartsville, SC | Transportation Equipment Manufacturing336612 | — | ◇ UNVERIFIED |
| SHSafe Harbor Access Systems Ii LLC | Quinby, SC | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| SSSun Superior Chipper Parts LLC | Darlington, SC | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| TCThomas Concrete - Florence | Florence, SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| UBUS Blades Sub LLC | Florence, SC | Fabricated Metal Product Manufacturing332216 | — | ◇ UNVERIFIED |
| WAWellman Advanced Materials LLC | Poston, SC | Chemical Manufacturing325222 | — | ◇ UNVERIFIED |
