| CDCatalyst Distilling, LLC | Fort Wayne, IN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CFClarios - Ft. Wayne | Fort Wayne, IN | Electrical Equipment, Appliance & Component Manufacturing335911 | 100–499 | ◐ LIKELY ACTIVE |
| CFCopper Forge Distilling, LLC | Fort Wayne, IN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| DIDana Inc. (Fort Wayne Facility) | Fort Wayne, IN | Transportation Equipment Manufacturing336350 | 500+ | ◐ LIKELY ACTIVE |
| D9Dash 90 Wines LLC | Warren, IN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| DCDeister Concentrator NA, LLC | Fort Wayne, IN | Machinery Manufacturing333131 | 1–19 | ◐ LIKELY ACTIVE |
| DMDeister Machine Company - Berry | Fort Wayne, IN | Machinery Manufacturing333131 | 1–19 | ◐ LIKELY ACTIVE |
| DMDeister Machine Company - Glasgow | Fort Wayne, IN | Machinery Manufacturing333131 | 20–99 | ◐ LIKELY ACTIVE |
| DMDeister Machine Company - Grant | Fort Wayne, IN | Machinery Manufacturing333131 | 20–99 | ◐ LIKELY ACTIVE |
| DMDeister Machine Company - Pontiac | Fort Wayne, IN | Machinery Manufacturing333131 | 100–499 | ◐ LIKELY ACTIVE |
| DBD.l. Banks & Sons LLC | Fort Wayne, IN | Fabricated Metal Product Manufacturing332321 | — | ◐ LIKELY ACTIVE |
| DGDreyer's Grand Ice Cream | Fort Wayne, IN | Food Manufacturing311520 | 500+ | ◐ LIKELY ACTIVE |
| ECEdwin Coe LLC | Churubusco, IN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| EAEicher and Sons | Harlan, IN | Wood Product Manufacturing321113 | 1–19 | ◐ LIKELY ACTIVE |
| EErapsco | Columbia City, IN | Computer and Electronic Product Manufacturing334511 | — | ▲ REPORTED CLOSED |
| EFEssex Furukawa Fort Wayne Magnet Wire Plant | Fort Wayne, IN | Primary Metal Manufacturing331420 | 100–499 | ◐ LIKELY ACTIVE |
| FCFill-Rite Company (FTW) | Fort Wayne, IN | Machinery Manufacturing333911 | 100–499 | ◐ LIKELY ACTIVE |
| FRFlat Range Outfitters LLC | Huntertown, IN | Textile Product Mills314999 | — | ◐ LIKELY ACTIVE |
| FWFort Wayne Bakery | Fort Wayne, IN | Food Manufacturing311812 | 100–499 | ◐ LIKELY ACTIVE |
| FWFort Wayne IN | Fort Wayne, IN | Fabricated Metal Product Manufacturing332618 | 1–19 | ◐ LIKELY ACTIVE |
| FWFort Wayne Metals SMB | Fort Wayne, IN | Fabricated Metal Product Manufacturing332618 | 1–19 | ◐ LIKELY ACTIVE |
| FWFort Wayne Metals TEC | Fort, IN | Primary Metal Manufacturing331222 | 20–99 | ◐ LIKELY ACTIVE |
| FEFranklin Electric Co., Inc. | Fort Wayne, IN | Electrical Equipment, Appliance & Component Manufacturing335312 | 100–499 | ◐ LIKELY ACTIVE |
| FWFranklin Water Treatment - Churubusco | Churubusco, IN | Machinery Manufacturing333310 | 20–99 | ◐ LIKELY ACTIVE |
| FIFXI, Inc. - Fort Wayne | Fort Wayne, IN | Plastics and Rubber Products Manufacturing326150 | 100–499 | ◐ LIKELY ACTIVE |
| GMGeneral Motors | Roanoke, IN | Transportation Equipment Manufacturing336112 | 500+ | ◐ LIKELY ACTIVE |
| GGrabill | Grabill, IN | Chemical Manufacturing325991 | 20–99 | ◐ LIKELY ACTIVE |
| GCGrabill Canning Company | Grabill, IN | — | — | ◐ LIKELY ACTIVE |
| GIGracie Industries d/b/a Bolt Custom Trucks & Manufacturing | Fort Wayne, IN | Transportation Equipment Manufacturing336211 | 20–99 | ◐ LIKELY ACTIVE |
| HSHatfield & Sons, LLC | Fort Wayne, IN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| HSHersheys Salty Snacks | Bluffton, IN | Food Manufacturing311919 | 100–499 | ◐ LIKELY ACTIVE |
| HPHinsey's Pro Paint, Inc DBA Bad Dad | Fort Wayne, IN | Transportation Equipment Manufacturing336991 | 1–19 | ◐ LIKELY ACTIVE |
Hoosier Crane Service Company - Fort Wayne | Fort Wayne, IN | Machinery Manufacturing333923 | 1–19 | ◐ LIKELY ACTIVE |
| HHuntertown | Fort Wayne, IN | Computer and Electronic Product Manufacturing334419 | 100–499 | ◐ LIKELY ACTIVE |
| IGIasa Group LLC | Fort Wayne, IN | Transportation Equipment Manufacturing336413 | — | ◐ LIKELY ACTIVE |
Indiana Oxygen Company-Fort Wayne | Fort Wayne, IN | Chemical Manufacturing325120 | 1–19 | ◐ LIKELY ACTIVE |
| JBJames Building A | Fort Wayne, IN | Primary Metal Manufacturing331222 | 20–99 | ◐ LIKELY ACTIVE |
| JGJR Graber and Sons | Grabill, IN | Wood Product Manufacturing321920 | 20–99 | ◐ LIKELY ACTIVE |
| KTKaiser Tool Company, INC. | Fort Wayne, IN | Machinery Manufacturing333515 | — | ▲ REPORTED CLOSED |
| KCKekionga Cider Company | Fort Wayne, IN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| KOKeystone Office | Churubusco, IN | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| LL3Harris | Fort Wayne, IN | Computer and Electronic Product Manufacturing334511 | 500+ | ◐ LIKELY ACTIVE |
| LFLABECA - Ferguson | Fort Wayne, IN | Primary Metal Manufacturing331222 | 20–99 | ◐ LIKELY ACTIVE |
| LMLabeca - McArthur | Fort Wayne, IN | Primary Metal Manufacturing331222 | 20–99 | ◐ LIKELY ACTIVE |
| LCLear Corporation - Columbia City | Columbia City, IN | Transportation Equipment Manufacturing336360 | 500+ | ◐ LIKELY ACTIVE |
| LELevy Environmental Services Company dba Columbia City Mill Services | Columbia City, IN | Primary Metal Manufacturing331110 | 20–99 | ◐ LIKELY ACTIVE |
| MMMach Medical | Columbia City, IN | — | — | ◐ LIKELY ACTIVE |
| MFMahoney Foundries DBA Ward Corporation | Fort Wayne, IN | Transportation Equipment Manufacturing336212 | 100–499 | ◐ LIKELY ACTIVE |
| MSMaster Spas (Indiana) | Fort Wayne, IN | Plastics and Rubber Products Manufacturing326199 | 500+ | ◐ LIKELY ACTIVE |
| MIMatalco Inc. | Bluffton, IN | Primary Metal Manufacturing331314 | 20–99 | ◐ LIKELY ACTIVE |