| BOBest One Retread of Knoxville | Knoxville, TN | Plastics and Rubber Products Manufacturing326212 | 1–19 | ◐ LIKELY ACTIVE |
| BIBlair Image Elements - Tennessee | Knoxville, TN | Miscellaneous Manufacturing339950 | 20–99 | ◐ LIKELY ACTIVE |
| BSBlue Slip Winery | Knoxville, TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BSBlue Slip Winery | Knoxville, TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BIBrozelco INC | Rockford, TN | Electrical Equipment, Appliance & Component Manufacturing335313 | — | ◐ LIKELY ACTIVE |
| CECentrus Energy ACO-OR | Oak Ridge, TN | Machinery Manufacturing333998 | 100–499 | ◐ LIKELY ACTIVE |
| CHCentury Harvest Farms LLC | Greenback, TN | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| CHCentury Harvest LLC | Greenback, TN | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| CMCe-ri-ss Materials LLC | Knoxville, TN | Primary Metal Manufacturing331524 | — | ◐ LIKELY ACTIVE |
| CGChroma Graphics | Maryville, TN | Printing and Related Support Activities323111 | 1–19 | ◐ LIKELY ACTIVE |
| CRClinch River Rum Company LLC | Oak Ridge, TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CRCMC Rebar Knoxville | Knoxville, TN | Fabricated Metal Product Manufacturing332312 | 20–99 | ◐ LIKELY ACTIVE |
| CMCmh Manufacturing INC | Maryville, TN | Wood Product Manufacturing321991 | — | ◐ LIKELY ACTIVE |
| CMCnc Machinery Solutions, INC | Lenoir City, TN | Computer and Electronic Product Manufacturing334111 | — | ◐ LIKELY ACTIVE |
| CDCompany Distilling | Townsend, TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CPConsumer Packaging Knoxville F | Knoxville, TN | Paper Manufacturing322212 | 100–499 | ◐ LIKELY ACTIVE |
| CCCopper Cellar Corp | Knoxville, TN | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| CBCrafty Bastard Brewery, INC. | Knoxville, TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
Crane 1 Services - Knoxville | Knoxville, TN | Machinery Manufacturing333923 | 1–19 | ◐ LIKELY ACTIVE |
| CMCuts Manufacturing, INC. | Knoxville, TN | Machinery Manufacturing333120 | — | ◐ LIKELY ACTIVE |
| DIDarling Ingredients-Knoxville 325 | Strawberry Plains, TN | Food Manufacturing311613 | 20–99 | ◐ LIKELY ACTIVE |
| DSDempster Sales, INC. | Knoxville, TN | Transportation Equipment Manufacturing336211 | — | ◐ LIKELY ACTIVE |
| DLDeRoyal LaFollette | La Follette, TN | Miscellaneous Manufacturing339113 | 100–499 | ◐ LIKELY ACTIVE |
| DODeRoyal Orthopedic Fabrication | Maynardville, TN | Miscellaneous Manufacturing339113 | 1–19 | ◐ LIKELY ACTIVE |
| DZDrop Zone Distilling Company, LLC | Knoxville, TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| DLDWK Life Sciences Rockwood | Rockwood, TN | Nonmetallic Mineral Product Manufacturing327215 | 100–499 | ◐ LIKELY ACTIVE |
| DTD&w Tool CO INC | Lenoir City, TN | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| DIDyke Industries, Inc | Knoxville, TN | Wood Product Manufacturing321911 | 20–99 | ◐ LIKELY ACTIVE |
| ETEast Tn Machining LLC | Jacksboro, TN | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| ESEdwin + Sons Cocktail Co. | Knoxville, TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| EKElo KOC | Knoxville, TN | Computer and Electronic Product Manufacturing334118 | 20–99 | ◐ LIKELY ACTIVE |
| EOEndolimb Orthoplastic Solutions, INC. | Knoxville, TN | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| EEETI Elkhart / Tri-Went Industrial | Knoxville, TN | Fabricated Metal Product Manufacturing332996 | 20–99 | ◐ LIKELY ACTIVE |
| FFF.j. Feddersen, INC. | Loudon, TN | Fabricated Metal Product Manufacturing332994 | — | ◐ LIKELY ACTIVE |
| FFlex-N-Gate | Rockford, TN | Plastics and Rubber Products Manufacturing326199 | 100–499 | ◐ LIKELY ACTIVE |
| FBFlock Beer & Wine | Knoxville, TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FPFlying Panda Specialty Beverage Co. | Rockwood, TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FMFox Machine INC. | Wartburg, TN | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| FMFresenius Medical Care | Knoxville, TN | Chemical Manufacturing325412 | 100–499 | ◐ LIKELY ACTIVE |
| GPGeon performance Solutions | Clinton, TN | Chemical Manufacturing325991 | 20–99 | ◐ LIKELY ACTIVE |
| GTGeren Toby | Clinton, TN | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| GMGilded Mirrors and Glass LLC | Maryville, TN | Nonmetallic Mineral Product Manufacturing327215 | 20–99 | ◐ LIKELY ACTIVE |
| GCGypsy Circus Cider Company, LLC | Knoxville, TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| HDHarper David Charles | Kingston, TN | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| HSHarvest Station Foods, LLC | Loudon, TN | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| H5HEC 5501 Island River Drive | Knoxville, TN | Fabricated Metal Product Manufacturing332420 | 1–19 | ◐ LIKELY ACTIVE |
| HCHGI Clinton | Clinton, TN | Chemical Manufacturing325120 | 1–19 | ◐ LIKELY ACTIVE |
| HHHGI Harriman | Harriman, TN | Chemical Manufacturing325120 | 1–19 | ◐ LIKELY ACTIVE |
| HJHGI Jacksboro | Jacksboro, TN | Chemical Manufacturing325120 | 1–19 | ◐ LIKELY ACTIVE |
| HKHGI Knoxville | Knoxville, TN | Chemical Manufacturing325120 | 100–499 | ◐ LIKELY ACTIVE |