| VVVishay Vitramon Incorporated | Roanoke, VA | Nonmetallic Mineral Product Manufacturing327113 | — | ◇ UNVERIFIED |
| WMWalker Machine and Foundry | Roanoke, VA | Primary Metal Manufacturing331511 | — | ◇ UNVERIFIED |
| WVWelcome Valley Asphalt Plant | Roanoke, VA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| WBWestern Branch Diesel | Roanoke, VA | Machinery Manufacturing333613 | — | ◇ UNVERIFIED |
| 1P15 Peaks, LLC | Roanoke, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| 1R168 Roanoke VA | Roanoke, VA | Food Manufacturing311811 | 20–99 | ◐ LIKELY ACTIVE |
| AFA Few Old Goats Brewing | Roanoke, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| ARAmg Roa | Roanoke, VA | Fabricated Metal Product Manufacturing332710 | 1–19 | ◐ LIKELY ACTIVE |
| ASAnthro Systems Limited | Roanoke, VA | Miscellaneous Manufacturing339920 | — | ◐ LIKELY ACTIVE |
| AAAssociated Asphalt Partners, LLC | Roanoke, VA | Petroleum and Coal Products Manufacturing324121 | 20–99 | ◐ LIKELY ACTIVE |
| ADAtheling Downtown | Roanoke, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| AMAtheling Meadworks | Roanoke, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BCBarrel Chest Wine And Beer | Roanoke, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BMBent Mountain Winery | Bent Mountain, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BEBering Engineering LLC | Glade Hill, VA | Computer and Electronic Product Manufacturing334112 | — | ◐ LIKELY ACTIVE |
| BLBig Lick Brewing Co | Roanoke, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BRBlue Ridge Vineyard | Eagle Rock, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BDBrady's Distillery | Roanoke, VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| BMBrooks Mill Winery | Wirtz, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CRC215 Roanoke PC | Roanoke, VA | Beverage and Tobacco Product Manufacturing312111 | 100–499 | ◐ LIKELY ACTIVE |
| CRCarris Reels VA Plastics | Fincastle, VA | Plastics and Rubber Products Manufacturing326199 | 20–99 | ◐ LIKELY ACTIVE |
| CIChem-solv, INC. | Roanoke, VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CPCowboy's Process Piping, LLC | Glade Hill, VA | Machinery Manufacturing333992 | — | ◐ LIKELY ACTIVE |
| CSCP&P Salem | Salem, VA | Nonmetallic Mineral Product Manufacturing327390 | 20–99 | ◐ LIKELY ACTIVE |
| CRCrooked Road | Ferrum, VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CRCrooked Road | Rocky Mount, VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CCvt-va | Roanoke, VA | Computer and Electronic Product Manufacturing334419 | 1–19 | ◐ LIKELY ACTIVE |
| DBDominion Block LLC - Roanoke | Roanoke, VA | Nonmetallic Mineral Product Manufacturing327331 | 1–19 | ◐ LIKELY ACTIVE |
| DSDominion Solutions INC | Roanoke, VA | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| FIFrameco, INC. | Salem, VA | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| GWGraham White 1242 | Salem, VA | Transportation Equipment Manufacturing336510 | 100–499 | ◐ LIKELY ACTIVE |
| GWGraham White Foundry 1201 | Salem, VA | Primary Metal Manufacturing331511 | 20–99 | ◐ LIKELY ACTIVE |
| IInfoSeal | Roanoke, VA | Printing and Related Support Activities323120 | 20–99 | ◐ LIKELY ACTIVE |
| JLJohn L Etzler, Inc. | Troutville, VA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| KFKC Farms Meats, LLC | Ferrum, VA | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| KCKIK Consumer Products | Salem, VA | Chemical Manufacturing325612 | 100–499 | ◐ LIKELY ACTIVE |
| KRKoppers Roanoke | Roanoke, VA | Wood Product Manufacturing321114 | 20–99 | ◐ LIKELY ACTIVE |
| LVLakehill Vineyards, INC. | Callaway, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| LSLaw Shine, LLC | Rocky Mount, VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| LPLiving Proof Beer Company LLC | Rocky Mount, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MIMaranon, INC. | Eagle Rock, VA | Machinery Manufacturing333310 | — | ◐ LIKELY ACTIVE |
| MCMarvin Composites - Salem | Salem, VA | Plastics and Rubber Products Manufacturing326199 | 100–499 | ◐ LIKELY ACTIVE |
| MCMativ Conwed LLC | Roanoke, VA | Plastics and Rubber Products Manufacturing326199 | 20–99 | ◐ LIKELY ACTIVE |
| NTNexhaul Trailers | Rocky Mount, VA 24151, VA | Transportation Equipment Manufacturing336212 | 20–99 | ◐ LIKELY ACTIVE |
| NNordt | Roanoke, VA | Miscellaneous Manufacturing339910 | 20–99 | ◐ LIKELY ACTIVE |
| ONONW NAM Salem Engineering Lab | Salem, VA | Machinery Manufacturing333611 | 20–99 | ◐ LIKELY ACTIVE |
| PRPlygem Rocky Mount - US Windows | Rocky Mount, VA | Plastics and Rubber Products Manufacturing326199 | 500+ | ◐ LIKELY ACTIVE |
| QDQualiChem Distribution Center | Salem, VA | Chemical Manufacturing325998 | 1–19 | ◐ LIKELY ACTIVE |
Qualichem, Inc -Plant 2 | Salem, VA | Chemical Manufacturing325998 | 1–19 | ◐ LIKELY ACTIVE |
Qualichem, Inc.- Research Center | Salem, VA | Chemical Manufacturing325998 | 1–19 | ◐ LIKELY ACTIVE |