| BVBillsboro Vineyards and Winery, LLC | Geneva, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BBBlackbox Biometrics INC | Rochester, NY | Computer and Electronic Product Manufacturing334519 | — | ◐ LIKELY ACTIVE |
| BBBlack Button Distilling | Rochester, NY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| BCBlackspot CORP | Rochester, NY | Transportation Equipment Manufacturing336411 | — | ◐ LIKELY ACTIVE |
| BFBlake Farms Hard Apple Cider, LLC | Wolcott, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BTBloomfield TekniPlex | Bloomfield, NY | Plastics and Rubber Products Manufacturing326140 | 100–499 | ◐ LIKELY ACTIVE |
| BBBlue Barn Cidery | Hilton, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BTBlue Toad Hard Cider | Rochester, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BPBoom Point | Williamson, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BFBostrom Farms, LLC | Stanley, NY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| BPBranding Promotions LLC | Avon, NY | Textile Product Mills314110 | — | ◐ LIKELY ACTIVE |
| BVBristol Valley Vineyards, INC. | Bloomfield, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BFBrockport Facility | Brockport, NY | Food Manufacturing311411 | 100–499 | ◐ LIKELY ACTIVE |
| BNBrockport Northrup Ready Mix | Brockport, NY | Nonmetallic Mineral Product Manufacturing327320 | 1–19 | ◐ LIKELY ACTIVE |
| BCBrooklyn Cider House LLC | Geneva, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BIBrothers International Food Holdings LLC | Rochester, NY | Food Manufacturing311423 | 20–99 | ◐ LIKELY ACTIVE |
| CRCalvary Robotics - Webster, NY | Webster, NY | Fabricated Metal Product Manufacturing332710 | 100–499 | ◐ LIKELY ACTIVE |
| CACane and Vine Wine Cellars | Geneva, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| C1Carestream 1049 | Rochester, NY | Computer and Electronic Product Manufacturing334517 | 100–499 | ◐ LIKELY ACTIVE |
| CHCarestream Health Rochester Building 117 | Rochester, NY | Chemical Manufacturing325992 | 1–19 | ◐ LIKELY ACTIVE |
| CHCarestream Health Rochester Building 12 | Rochester, NY | Chemical Manufacturing325992 | 20–99 | ◐ LIKELY ACTIVE |
| CMCentury Mold-TN | Rochester, NY | Machinery Manufacturing333249 | 100–499 | ◐ LIKELY ACTIVE |
| CBCharles Brown | Rochester, NY | Apparel Manufacturing315990 | — | ◐ LIKELY ACTIVE |
| CFChimera Forge LLC | Canandaigua, NY | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |
| CBCHR Building 14 | Rochester, NY | Chemical Manufacturing325992 | 1–19 | ◐ LIKELY ACTIVE |
| CAChuck and Arbor LLC | Holley, NY | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| CPCorrosion Products & Equipment - Rochester | Rochester, NY | Machinery Manufacturing333914 | 1–19 | ◐ LIKELY ACTIVE |
| DUDanisco USA, Inc | Rochester, NY | Machinery Manufacturing333249 | 100–499 | ◐ LIKELY ACTIVE |
| DUDanisco US, Inc | Rochester, NY | Chemical Manufacturing325199 | 20–99 | ◐ LIKELY ACTIVE |
| DPDansville Plant | Dansville, NY | Printing and Related Support Activities323111 | 20–99 | ◐ LIKELY ACTIVE |
| Ddennies | Canandaigua, NY | Fabricated Metal Product Manufacturing332710 | 20–99 | ◐ LIKELY ACTIVE |
DJ Acquisition Management Corp. - Henrietta | Henrietta, NY | Fabricated Metal Product Manufacturing332710 | 20–99 | ◐ LIKELY ACTIVE |
| DIDrapery Industries, Inc. | Rochester, NY | Furniture and Related Product Manufacturing337920 | 1–19 | ◐ LIKELY ACTIVE |
Eastman Kodak Company- Eastman Business Park | Rochester, NY | Chemical Manufacturing325992 | 500+ | ◐ LIKELY ACTIVE |
| EGEb & G Enterprises, INC | Fairport, NY | Fabricated Metal Product Manufacturing332323 | — | ◐ LIKELY ACTIVE |
| EREIS - Rochester | Rochester, NY | Electrical Equipment, Appliance & Component Manufacturing335932 | 100–499 | ◐ LIKELY ACTIVE |
| EKElderberry Knoll Winery | Albion, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
Elmira Stamping & Manufacturing - North | Rochester, NY | Fabricated Metal Product Manufacturing332119 | 20–99 | ◐ LIKELY ACTIVE |
| ECEmbark Craft Ciderworks | Williamson, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| EUEnd Use Pro, LLC | Rochester, NY | Chemical Manufacturing325611 | — | ◐ LIKELY ACTIVE |
| EMEngineered Materials Fairport | Fairport, NY | Plastics and Rubber Products Manufacturing326199 | 100–499 | ◐ LIKELY ACTIVE |
| EMEngineered Materials Marion | Marion, NY | Plastics and Rubber Products Manufacturing326121 | 20–99 | ◐ LIKELY ACTIVE |
| EIEoptic, INC. | Rochester, NY | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| ETEPP Team LLC. | Rochester, NY | Machinery Manufacturing333248 | 20–99 | ◐ LIKELY ACTIVE |
| EPErdle Perforating - Rochester | Rochester, NY | Fabricated Metal Product Manufacturing332119 | 20–99 | ◐ LIKELY ACTIVE |
| EREvolve - ROC | Rochester, NY | Machinery Manufacturing333249 | 1–19 | ◐ LIKELY ACTIVE |
| FBFairport Brewing Company | Rochester, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FLFiltros Limited | East Rochester, NY | Nonmetallic Mineral Product Manufacturing327120 | 1–19 | ◐ LIKELY ACTIVE |
| FRFirth Rixson - Rochester | Rochester, NY | Fabricated Metal Product Manufacturing332112 | 100–499 | ◐ LIKELY ACTIVE |
| FSFive Sons Winery, INC. | Brockport, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |