| PIPennant Ingredients Buffalo Rd Location | Rochester, NY | Food Manufacturing311812 | 20–99 | ◐ LIKELY ACTIVE |
| PIPennant Ingredients Chester Location | Rochester, NY | Food Manufacturing311812 | 20–99 | ◐ LIKELY ACTIVE |
| PNPfisterer North America | Rochester, NY | Electrical Equipment, Appliance & Component Manufacturing335931 | 20–99 | ◐ LIKELY ACTIVE |
| PTPhinney Tool & Die Company | Medina, NY | Machinery Manufacturing333514 | 20–99 | ◐ LIKELY ACTIVE |
| PGPhoenix Graphics, Inc. | Rochester, NY | Printing and Related Support Activities323111 | 20–99 | ◐ LIKELY ACTIVE |
| PYPic Yer Poison INC | Yates, NY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| P1Plant 1 | Rochester, NY | Machinery Manufacturing333415 | 20–99 | ◐ LIKELY ACTIVE |
| PPPlug Power | West Henrietta, NY | Electrical Equipment, Appliance & Component Manufacturing335999 | 100–499 | ◐ LIKELY ACTIVE |
| PHPMD & Headquarters | Rochester, NY | Fabricated Metal Product Manufacturing332999 | 20–99 | ◐ LIKELY ACTIVE |
| PEPolymer Engineered Products, Inc | Rochester, NY | Plastics and Rubber Products Manufacturing326199 | 20–99 | ◐ LIKELY ACTIVE |
| PEPrimalyn Enterprises DBA Jason Manufacturing | Rochester, NY | Furniture and Related Product Manufacturing337211 | 20–99 | ◐ LIKELY ACTIVE |
| PPrintegra | Fairport, NY | Printing and Related Support Activities323111 | 20–99 | ◐ LIKELY ACTIVE |
| PTP Tool & Die Co., Inc. | North Chili, NY | Machinery Manufacturing333514 | 20–99 | ◐ LIKELY ACTIVE |
| QRQuidelOrtho Rochester 642 | Rochester, NY | Chemical Manufacturing325413 | 100–499 | ◐ LIKELY ACTIVE |
| QRQuidelOrtho Rochester CNP100 | Rochester, NY | Chemical Manufacturing325413 | 100–499 | ◐ LIKELY ACTIVE |
| QRQuidelOrtho Rochester CNP 130 | Rochester, NY | Chemical Manufacturing325413 | 100–499 | ◐ LIKELY ACTIVE |
| QGQuorum Group dba Takeform | Medina, NY | Miscellaneous Manufacturing339950 | 100–499 | ◐ LIKELY ACTIVE |
| RDRanger Design Inc. | Webster, NY | Transportation Equipment Manufacturing336360 | 20–99 | ◐ LIKELY ACTIVE |
| RERaymor Estate Cellars, LLC | Bloomfield, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RFR&D Facility | Rochester, NY | Machinery Manufacturing333924 | 20–99 | ◐ LIKELY ACTIVE |
| RORe:Build Optimation Technology, LLC | Rush, NY | Fabricated Metal Product Manufacturing332999 | 100–499 | ◐ LIKELY ACTIVE |
| RJRed Jacket Orchards | Geneva, NY | Food Manufacturing311411 | 20–99 | ◐ LIKELY ACTIVE |
| RDRegional Defense Services, LLC | Henrietta, NY | Transportation Equipment Manufacturing336120 | — | ◐ LIKELY ACTIVE |
| RERobinson Estates | Ontario, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RBRochester Branch | Victor, NY | Machinery Manufacturing333995 | 1–19 | ◐ LIKELY ACTIVE |
| RNRochester, NY (Mastodon) (Q14) | Rochester, NY | Computer and Electronic Product Manufacturing334220 | 100–499 | ◐ LIKELY ACTIVE |
| RRRochester Ready Mix | Rochester, NY | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| RSRochester Structural LLC | Rochester, NY | Fabricated Metal Product Manufacturing332312 | 20–99 | ◐ LIKELY ACTIVE |
| RTRochester - Teale | Rochester, NY | Fabricated Metal Product Manufacturing332721 | 20–99 | ◐ LIKELY ACTIVE |
| RGRonald Garrow | Rochester, NY | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| RNRosenkrans Natural Beef Company, LLC | Rochester, NY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RMRush Machinery, INC. | Rushville, NY | Machinery Manufacturing333515 | — | ◐ LIKELY ACTIVE |
| SESalamaca Estate Winery | Albion, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SASchutt's Apple Mill | Webster, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SWSchwenk Wine Cellars LLC | Kent, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SASeed and Stone Cidery | Rochester, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SSShale Spring Meats, LLC | Clyde, NY | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| SESimcona Electronics Corp MC | Rochester, NY | Electrical Equipment, Appliance & Component Manufacturing335314 | 20–99 | ◐ LIKELY ACTIVE |
| SIsimpore inc. | West Henrietta, NY | Computer and Electronic Product Manufacturing334413 | 1–19 | ◐ LIKELY ACTIVE |
| SDSir Delicious | Rochester, NY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| STSmokin' Tails Distillery | Phelps, NY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SSSolid Surfaces NY Rochester | Rochester, NY | Nonmetallic Mineral Product Manufacturing327991 | 20–99 | ◐ LIKELY ACTIVE |
| SHSong Hill Winery, LLC | Victor, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SCSOR Controls Group Rochester | Rochester, NY | Computer and Electronic Product Manufacturing334513 | 1–19 | ◐ LIKELY ACTIVE |
| SISouthco, Inc. at Honeoye Falls Location | Honeoye Falls, NY | Fabricated Metal Product Manufacturing332722 | 100–499 | ◐ LIKELY ACTIVE |
| SCStar Cider, LLC | Canandaigua, NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SSStar Safety Technologies by Grote | Avon, NY | Transportation Equipment Manufacturing336320 | 20–99 | ◐ LIKELY ACTIVE |
| SMSwan Market | Rochester, NY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| TETcs Electronics INC | Farmington, NY | Computer and Electronic Product Manufacturing334418 | — | ◐ LIKELY ACTIVE |
| TITeknic, Inc | Victor, NY | Electrical Equipment, Appliance & Component Manufacturing335312 | 20–99 | ◐ LIKELY ACTIVE |