| HPHazen Paper Company West Plant | Holyoke, MA | Paper Manufacturing322110 | 20–99 | ◐ LIKELY ACTIVE |
| HPHolyoke Paper - B353 | Holyoke, MA | Paper Manufacturing322121 | 20–99 | ◐ LIKELY ACTIVE |
| JAJain Americas Inc. | Chicopee, MA | Plastics and Rubber Products Manufacturing326199 | 20–99 | ◐ LIKELY ACTIVE |
| JAJames Austin Company / KIK Consumer Products | Ludlow, MA | Chemical Manufacturing325612 | 20–99 | ◐ LIKELY ACTIVE |
| JHJames Hardie Building Products, Inc. Westfield | Westfield, MA | Nonmetallic Mineral Product Manufacturing327390 | 20–99 | ◐ LIKELY ACTIVE |
| JTJeff The Butcher Company | Westfield, MA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| KGKikwala Group LLC | West Springfield, MA | Chemical Manufacturing325620 | — | ◐ LIKELY ACTIVE |
| KSKleeberg SheetMetal | Ludlow, MA | Fabricated Metal Product Manufacturing332322 | 100–499 | ◐ LIKELY ACTIVE |
| KDKokusai Denki Electric America, INC. | Southwick, MA | Computer and Electronic Product Manufacturing334310 | — | ◐ LIKELY ACTIVE |
| KFKosinski Farms | Westfield, MA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| KUKpr Us, LLC | Chicopee, MA | Computer and Electronic Product Manufacturing334510 | 100–499 | ◐ LIKELY ACTIVE |
| LVLazy Valley Winery | Springfield, MA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| L7Lot 707 | Southwick, MA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| LLudlow | Ludlow, MA | Plastics and Rubber Products Manufacturing326122 | 100–499 | ◐ LIKELY ACTIVE |
| MPMa236 Paragon Medical, INC. 373 Whitney Ave | Holyoke, MA | Miscellaneous Manufacturing339112 | 20–99 | ◐ LIKELY ACTIVE |
| MIMicroTek, Inc. | Chicopee, MA | Computer and Electronic Product Manufacturing334419 | 20–99 | ◐ LIKELY ACTIVE |
| NVNational Vinyl, LLC | Chicopee, MA | Plastics and Rubber Products Manufacturing326199 | 20–99 | ◐ LIKELY ACTIVE |
| NINovacel Incorporated | Palmer, MA | Paper Manufacturing322220 | 20–99 | ◐ LIKELY ACTIVE |
 Oerlikon Balzers Coating USA Inc - Agawam | Agawam, MA | Fabricated Metal Product Manufacturing332812 | 20–99 | ◐ LIKELY ACTIVE |
| OBOMG Building Products LLC | Agawam, MA | Fabricated Metal Product Manufacturing332722 | 500+ | ◐ LIKELY ACTIVE |
| PPalmer | Palmer, MA | Beverage and Tobacco Product Manufacturing312113 | 20–99 | ◐ LIKELY ACTIVE |
| PGPerma Graphics INC | Westfield, MA | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| PWPlacon West Springfield | West Springfield, MA | Plastics and Rubber Products Manufacturing326199 | 20–99 | ◐ LIKELY ACTIVE |
| PEPlastipak- East Longmeadow | East Longmeadow, MA | Plastics and Rubber Products Manufacturing326160 | 100–499 | ◐ LIKELY ACTIVE |
| PMProfessional Machine Service, LLC | Holyoke, MA | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| QBQueen Bee Vineyard INC. | Monson, MA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RFRachael's Food Corporation | Chicopee, MA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| SBSandman's Blueberries | Granville, MA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SRScantic River Brewery, LLC | Wilbraham, MA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SLSerco - Ludlow, MA | Ludlow, MA | Computer and Electronic Product Manufacturing334290 | 20–99 | ◐ LIKELY ACTIVE |
| SISkelotech International LLC | Chicopee, MA | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| SSSole Syndicate Distilling | Ludlow, MA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SSpringfield | Springfield, MA | Food Manufacturing311911 | 20–99 | ◐ LIKELY ACTIVE |
| SMSpringfield, MA | Springfield, MA | Food Manufacturing311612 | 100–499 | ◐ LIKELY ACTIVE |
| SMSpringfield Ma | East Longmeadow, MA | Printing and Related Support Activities323111 | 20–99 | ◐ LIKELY ACTIVE |
| SSsc-ma | East Longmeadow, MA | Fabricated Metal Product Manufacturing332613 | 20–99 | ◐ LIKELY ACTIVE |
| SBStanley Black and Decker | East Longmeadow, MA | Fabricated Metal Product Manufacturing332216 | 500+ | ◐ LIKELY ACTIVE |
| TLTigerPress LLC | East Longmeadow, MA | Printing and Related Support Activities323111 | 20–99 | ◐ LIKELY ACTIVE |
| TRTobacco Road Distillers | Southwick, MA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| TDTova D&S Industries | Southwick, MA | Computer and Electronic Product Manufacturing334511 | 20–99 | ◐ LIKELY ACTIVE |
| UTUFP Technologies | Chicopee Ma, 01020, MA | Plastics and Rubber Products Manufacturing326113 | 100–499 | ◐ LIKELY ACTIVE |
| WPWestfield Plant | Westfield, MA | Nonmetallic Mineral Product Manufacturing327320 | 1–19 | ◐ LIKELY ACTIVE |
| WCWhip City Jerky, LLC | Westfield, MA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| WWilbraham | Wilbraham, MA | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| WIWinwick INC | Chicopee, MA | Transportation Equipment Manufacturing336413 | — | ◐ LIKELY ACTIVE |
| YGYour Grand Father's Wine Cellar | Springfield, MA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| ZMZonin's Meats Inc. | Springfield, MA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| QTQuality Tool Company , Incorporated | Monson, MA | Machinery Manufacturing333514 | — | ◐ LIKELY ACTIVE |
| URUnited Refrigeration INC | Springfield, MA | Machinery Manufacturing333415 | — | ◐ LIKELY ACTIVE |
| BPBtd Precision, INC. | Chicopee, MA | Fabricated Metal Product Manufacturing332710 | — | ◇ UNVERIFIED |
