| NSNucor Skyline Steel LLC | Rock Hil | SC | Primary Metal Manufacturing331210 | 100-499 | ◐ LIKELY ACTIVE |
| NLNutramax Laboratories Inc. Building 3 | Lancaster | SC | Chemical Manufacturing325411 | 100-499 | ◐ LIKELY ACTIVE |
| OOrangeburg | Cope | SC | Primary Metal Manufacturing331318 | 100-499 | ◐ LIKELY ACTIVE |
| OSOrangeburg Sc Bakery | Orangeburg | SC | Food Manufacturing311812 | 100-499 | ◐ LIKELY ACTIVE |
| OMOrbis Mes | Piedmont | SC | Fabricated Metal Product Manufacturing332999 | 100-499 | ◐ LIKELY ACTIVE |
| OCOwens Corning | Starr | SC | Nonmetallic Mineral Product Manufacturing327212 | 100-499 | ◐ LIKELY ACTIVE |
| PAPatheon API, Inc. | Florence | SC | Chemical Manufacturing325411 | 100-499 | ◐ LIKELY ACTIVE |
Patrick Industries, Inc. d/b/a/ Engineered Metals & Composites Inc | West Columbia | SC | Fabricated Metal Product Manufacturing332312 | 100-499 | ◐ LIKELY ACTIVE |
| PIPattison ID | Heath Springs | SC | Miscellaneous Manufacturing339950 | 100-499 | ◐ LIKELY ACTIVE |
| P8Plant 8S | Columbia | SC | Chemical Manufacturing325220 | 100-499 | ◐ LIKELY ACTIVE |
Prime Materials Recovery, INC | Orangeburg | SC | Fabricated Metal Product Manufacturing332999 | 100-499 | ◐ LIKELY ACTIVE |
| PProduction | Heath Springs | SC | Textile Product Mills314999 | 100-499 | ◐ LIKELY ACTIVE |
| PProterra | Greer | SC | Transportation Equipment Manufacturing336320 | 100-499 | ◐ LIKELY ACTIVE |
| RCRaycap CHS | North Charleston | SC | Electrical Equipment, Appliance & Component Manufacturing335313 | 100-499 | ◐ LIKELY ACTIVE |
| RBRBC Bearings | Hartsville | SC | Fabricated Metal Product Manufacturing332991 | 100-499 | ◐ LIKELY ACTIVE |
| RMRidgeview Mfg. | Duncan | SC | Electrical Equipment, Appliance & Component Manufacturing335921 | 100-499 | ◐ LIKELY ACTIVE |
| RARoechling Automotive | Duncan | SC | Plastics and Rubber Products Manufacturing326199 | 100-499 | ◐ LIKELY ACTIVE |
| SMSargent Metal | Anderson | SC | Fabricated Metal Product Manufacturing332322 | 100-499 | ◐ LIKELY ACTIVE |
| SPSC150 Prosperity Plywood | Prosperity | SC | Wood Product Manufacturing321212 | 100-499 | ◐ LIKELY ACTIVE |
| SSSC220 Spartanburg Container | Spartanburg | SC | Paper Manufacturing322211 | 100-499 | ◐ LIKELY ACTIVE |
| SScfti | Greenville | SC | Textile Mills313210 | 100-499 | ◐ LIKELY ACTIVE |
| SASchedl Automotive System Service | Duncan | SC | Transportation Equipment Manufacturing336390 | 100-499 | ◐ LIKELY ACTIVE |
| SSSC - SPARTANBURG - 6135 Anderson Mill Rd | Moore | SC | Food Manufacturing311920 | 100-499 | ◐ LIKELY ACTIVE |
| SFSea Fox Boats | Moncks Corner | SC | Transportation Equipment Manufacturing336612 | 100-499 | ◐ LIKELY ACTIVE |
| SHSea Hunt Boats Manufacturing Co Inc | Columbia | SC | Transportation Equipment Manufacturing336611 | 100-499 | ◐ LIKELY ACTIVE |
| SESEW Eurodrive Lyman Manufacturing | Lyman | SC | Machinery Manufacturing333612 | 100-499 | ◐ LIKELY ACTIVE |
| SMSHL Medical | North Charleston | SC | Computer and Electronic Product Manufacturing334510 | 100-499 | ◐ LIKELY ACTIVE |
| SSofidel | Duncan | SC | Paper Manufacturing322291 | 100-499 | ◐ LIKELY ACTIVE |
| SSopakco (2) | Bennettsville | SC | Food Manufacturing311612 | 100-499 | ◐ LIKELY ACTIVE |
| SPSOPAKCO - Packaging | Mullins | SC | Nonmetallic Mineral Product Manufacturing327213 | 100-499 | ◐ LIKELY ACTIVE |
| SCSouth Carolina Distribution Center | Gaston | SC | Wood Product Manufacturing321911 | 100-499 | ◐ LIKELY ACTIVE |
| SMSouthwark Metal Greenville Division | Piedmont | SC | Fabricated Metal Product Manufacturing332322 | 100-499 | ◐ LIKELY ACTIVE |
| SSpartanburg | Spartanburg | SC | Textile Mills313230 | 100-499 | ◐ LIKELY ACTIVE |
| SMSpartanburg Milo's Tea | Moore | SC | Food Manufacturing311920 | 100-499 | ◐ LIKELY ACTIVE |
| SSSpartanburg Sc | Spartanburg | SC | Printing and Related Support Activities323111 | 100-499 | ◐ LIKELY ACTIVE |
SteelFab Inc Florence | Florence | SC | Fabricated Metal Product Manufacturing332312 | 100-499 | ◐ LIKELY ACTIVE |
| STSuminoe Textile of America | Gaffney | SC | Textile Product Mills314110 | 100-499 | ◐ LIKELY ACTIVE |
| SSSumter SC Truss | Sumter | SC | Wood Product Manufacturing321215 | 100-499 | ◐ LIKELY ACTIVE |
| SCSuominen Corporation | Bethine | SC | Textile Mills313230 | 100-499 | ◐ LIKELY ACTIVE |
| SSylvamo | Sumter | SC | Machinery Manufacturing333243 | 100-499 | ◐ LIKELY ACTIVE |
| TSTakeuchi SC01 | Moore | SC | Machinery Manufacturing333120 | 100-499 | ◐ LIKELY ACTIVE |
| TNThe Nason Company | Walhalla | SC | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| T5Thorne 558 Omni | Summeville | SC | Chemical Manufacturing325411 | 100-499 | ◐ LIKELY ACTIVE |
| TCTindall Corporation - Infrastructures | Spartanburg | SC | Nonmetallic Mineral Product Manufacturing327390 | 100-499 | ◐ LIKELY ACTIVE |
| TCTindall Corporation - South Carolina Division | Spartanburg | SC | Nonmetallic Mineral Product Manufacturing327390 | 100-499 | ◐ LIKELY ACTIVE |
| TCToray CMA Spartanburg SC | Moore | SC | Chemical Manufacturing325220 | 100-499 | ◐ LIKELY ACTIVE |
| TSTownville SC Truss | Townville | SC | Wood Product Manufacturing321215 | 100-499 | ◐ LIKELY ACTIVE |
| TMTransaxle Manufacturing of America Corp | Rock Hill | SC | Transportation Equipment Manufacturing336350 | 100-499 | ◐ LIKELY ACTIVE |
| TSTransport Solutions - Americas : MFG-Greenville, SC-USA | Greenville, SC | SC | Machinery Manufacturing333415 | 100-499 | ◐ LIKELY ACTIVE |
| TPTrimaco/Icon Protection | Manning | SC | Paper Manufacturing322299 | 100-499 | ◐ LIKELY ACTIVE |