| SSSioux Steel Company | Lennox | SD | Fabricated Metal Product Manufacturing332311 | 20-99 | ◐ LIKELY ACTIVE |
| UIUltiMed Inc. | De Smet | SD | Miscellaneous Manufacturing339112 | 20-99 | ◐ LIKELY ACTIVE |
| JCJosten Concrete Products Company, INC. | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327390 | 20-99 | ◐ LIKELY ACTIVE |
| QWQuality Wood Design | Mitchell | SD | Fabricated Metal Product Manufacturing332812 | 20-99 | ◇ UNVERIFIED |
| 2C21st Century Mfg. | Lake Preston | SD | Machinery Manufacturing333515 | 20-99 | ◐ LIKELY ACTIVE |
| DP"4083 - Dakota Panel Pick and Assembly" | Rapid City | SD | Wood Product Manufacturing321212 | 20-99 | ◐ LIKELY ACTIVE |
| AAAdvanced Ag Products | Canton | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
AFCO Performance Group dba Legend Suspensions | Sturgis | SD | Transportation Equipment Manufacturing336211 | 20-99 | ◐ LIKELY ACTIVE |
| AAAGP Aberdeen Soy | Aberdeen | SD | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| AFAlbany Farms | Belle Fourche | SD | Food Manufacturing311999 | 20-99 | ◐ LIKELY ACTIVE |
| BEBanner Engineering- Aberdeen, SD | Aberdeen | SD | Electrical Equipment, Appliance & Component Manufacturing335314 | 20-99 | ◐ LIKELY ACTIVE |
| BSBCI - Sioux Falls Division | Sioux Falls | SD | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| BWBroadway Welding - Watertown | Watertown | SD | Fabricated Metal Product Manufacturing332999 | 20-99 | ◐ LIKELY ACTIVE |
| BPBuilding Products Inc. of SD (Millwork) | Sioux Falls | SD | Wood Product Manufacturing321911 | 20-99 | ◐ LIKELY ACTIVE |
| CHCCL Healthcare | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| CFCounterpart Fabrication | Brookings | SD | Fabricated Metal Product Manufacturing332322 | 20-99 | ◐ LIKELY ACTIVE |
| CSCreative Surfaces of the Black Hills | Rapid City | SD | Furniture and Related Product Manufacturing337212 | 20-99 | ◐ LIKELY ACTIVE |
| CTCustom Truck One Source - Elk Point | Elk Point | SD | Transportation Equipment Manufacturing336212 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power OEM | Sioux Falls | SD | Fabricated Metal Product Manufacturing332912 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power Rapid City | Rapid City | SD | Fabricated Metal Product Manufacturing332912 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power SF | Sioux Falls | SD | Fabricated Metal Product Manufacturing332912 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakotaland Feeds Huron | Huron | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| EMEnertech Mitchell | Mitchell | SD | Machinery Manufacturing333415 | 20-99 | ◐ LIKELY ACTIVE |
| EPETRIA Products USA INC. | Mitchell | SD | Chemical Manufacturing325992 | 20-99 | ◐ LIKELY ACTIVE |
| FSFCP Sioux Falls | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| FEFermentation Experts USA LLC | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| FIFlagshooter, Inc | Sioux Falls | SD | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
| FFsdcp | Mitchell | SD | Nonmetallic Mineral Product Manufacturing327332 | 20-99 | ◐ LIKELY ACTIVE |
| GDG&H Distributing | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326220 | 20-99 | ◐ LIKELY ACTIVE |
Glacial Lakes Rubber & Plastics - Watertown | Watertown | SD | Plastics and Rubber Products Manufacturing326299 | 20-99 | ◐ LIKELY ACTIVE |
| GNGlanbia Nutritionals (NA) Inc. - Sioux Falls | Sioux Falls | SD | Food Manufacturing311211 | 20-99 | ◐ LIKELY ACTIVE |
| HSHarrold, SD | Harrold | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| MFMadison Facility | Madison | SD | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| MMMDS Mfg. Co. | MDS Mfg. Co. | SD | Machinery Manufacturing333111 | 20-99 | ◐ LIKELY ACTIVE |
| MMiller | St. Lawrence | SD | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| MMiller | Saint Lawrence | SD | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| MMitchell | Mitchell | SD | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| MSMitchell SD Truss | Mitchell | SD | Wood Product Manufacturing321215 | 20-99 | ◐ LIKELY ACTIVE |
| MIMiTek Inc. Britton | Britton | SD | Fabricated Metal Product Manufacturing332119 | 20-99 | ◐ LIKELY ACTIVE |
| MDMsp Dak Truss Pros Britton | Britton | SD | Wood Product Manufacturing321215 | 20-99 | ◐ LIKELY ACTIVE |
| NSNorth Sioux City | North Sioux City | SD | Food Manufacturing311111 | 20-99 | ◐ LIKELY ACTIVE |
| OHOVB HOLDINGS LLC DBA OVERBUILT and DBA EASIPOUR | Huron | SD | Machinery Manufacturing333120 | 20-99 | ◐ LIKELY ACTIVE |
| PPPerformance Pet Products | Mitchell | SD | Food Manufacturing311111 | 20-99 | ◐ LIKELY ACTIVE |
| PFPivotal Fab and Powder | Watertown | SD | Fabricated Metal Product Manufacturing332812 | 20-99 | ◐ LIKELY ACTIVE |
Prince Manufacturing Corporation-North Sioux City Campus | North Sioux City | SD | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
Prince Manufacturing Corporation-Yankton | Yankton | SD | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
| PFProForm Fabrication, LLC | Beresford | SD | Machinery Manufacturing333241 | 20-99 | ◐ LIKELY ACTIVE |
| PDPro-Tec Division | Lennox | SD | Machinery Manufacturing333111 | 20-99 | ◐ LIKELY ACTIVE |
| RRapcp | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327332 | 20-99 | ◐ LIKELY ACTIVE |
| RCRapid City (1016) | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |