| EIEnercept INC | Watertown | SD | Wood Product Manufacturing321992 | 20-99 | ◐ LIKELY ACTIVE |
| HLHmmi, LLC (formerly Horizontal Machining & Manufacturing, Inc.) | Huron | SD | Machinery Manufacturing333999 | 20-99 | ◐ LIKELY ACTIVE |
| PBPoet Biorefining Big Stone | Big Stone City | SD | Chemical Manufacturing325193 | 20-99 | ◐ LIKELY ACTIVE |
| RERedfield Energy, LLC | Redfield | SD | Chemical Manufacturing325110 | 20-99 | ◐ LIKELY ACTIVE |
| SIScotchman Industries INC | Philip | SD | Machinery Manufacturing333512 | 20-99 | ◐ LIKELY ACTIVE |
| SDSouth Dakota Partners, INC. | Clear Lake | SD | Computer and Electronic Product Manufacturing334510 | 20-99 | ◐ LIKELY ACTIVE |
Trail-eze INC. | Mitchell | SD | Transportation Equipment Manufacturing336212 | 20-99 | ◐ LIKELY ACTIVE |
| VMVrc Metal Systems LLC | Box Elder | SD | Machinery Manufacturing333519 | 20-99 | ◐ LIKELY ACTIVE |
| HSHfw Solutions | Rapid City | SD | Miscellaneous Manufacturing339999 | 20-99 | ◐ LIKELY ACTIVE |
| MFMeyerink Farm Service INC. | Platte | SD | Machinery Manufacturing333111 | 20-99 | ◐ LIKELY ACTIVE |
| MMMitchell Manufacturing, LLC | Mitchell | SD | Miscellaneous Manufacturing339920 | 20-99 | ◐ LIKELY ACTIVE |
| OLOmega Liner Company, INC. | Canton | SD | Plastics and Rubber Products Manufacturing326122 | 20-99 | ◐ LIKELY ACTIVE |
| SISencore INC. | Sioux Falls | SD | Computer and Electronic Product Manufacturing334290 | 20-99 | ◐ LIKELY ACTIVE |
| WMWheeler Manufacturing Co, INC. | Lemmon | SD | Miscellaneous Manufacturing339911 | 20-99 | ◐ LIKELY ACTIVE |
| AMAberdeen Machine Tool Inc. | Aberdeen | SD | Machinery Manufacturing333517 | 20-99 | ◐ LIKELY ACTIVE |
| ANAcco Nutting | Watertown | SD | Machinery Manufacturing333924 | 20-99 | ◐ LIKELY ACTIVE |
| ANAgriCare Nutrition | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| BFBenchmark Foam, INC. | Watertown | SD | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| ESEgger Steel Company | Sioux Falls | SD | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| MAMyrl and Roy's Paving, INC. | Sioux Falls | SD | Petroleum and Coal Products Manufacturing324121 | 20-99 | ◐ LIKELY ACTIVE |
| PMP & M Steel | Sioux Falls | SD | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| PUPPD USA Inc | Madison | SD | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| RPRainbow Play Systems, Inc. | Brookings | SD | Miscellaneous Manufacturing339920 | 20-99 | ◐ LIKELY ACTIVE |
| RPRapid Precision Mfg | Britton | SD | Fabricated Metal Product Manufacturing332710 | 20-99 | ◐ LIKELY ACTIVE |
| RPRoyal Plastics Inc. | Brookings | SD | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| SIScherer Inc. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332710 | 20-99 | ◐ LIKELY ACTIVE |
| SLSenproco, LLC | Sioux Falls | SD | Chemical Manufacturing325611 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakotaland Feeds LLC | Huron | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| EMEsco Manufacturing, INC. | Watertown | SD | Miscellaneous Manufacturing339950 | 20-99 | ◐ LIKELY ACTIVE |
| AAA & a Engraving INC | Rapid City | SD | Fabricated Metal Product Manufacturing332813 | 20-99 | ◐ LIKELY ACTIVE |
| AMAviation Manufacturing Group, LLC DBA The Freeman Company | Yankton | SD | Transportation Equipment Manufacturing336413 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Foundry, INC. | Webster | SD | Primary Metal Manufacturing331511 | 20-99 | ◐ LIKELY ACTIVE |
| JEJerry's Electric, INC | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | 20-99 | ◐ LIKELY ACTIVE |
| JDJr Distributing INC | Lake Norden | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| MMMds Manufacturing | Parkston | SD | Fabricated Metal Product Manufacturing332212 | 20-99 | ◐ LIKELY ACTIVE |
| NNNovita Nutrition, LLC | Brookings | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| PSPreform Solutions, INC. | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
Sd Industries | Alexandria | SD | Primary Metal Manufacturing331210 | 20-99 | ◐ LIKELY ACTIVE |
| WSWatertown SD | Watertown | SD | Primary Metal Manufacturing331523 | 20-99 | ◐ LIKELY ACTIVE |
| ARAce Ready Mix- Sioux Falls | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| BTBaker Timber Products Inc. | Rapid City | SD | Wood Product Manufacturing321113 | 20-99 | ◐ LIKELY ACTIVE |
| DSDakota Style | Clark | SD | Food Manufacturing311911 | 20-99 | ◐ LIKELY ACTIVE |
| DPDak Pak LLC | Woonsocket | SD | Chemical Manufacturing325412 | 20-99 | ◐ LIKELY ACTIVE |
| ESEast Side Jersey Dairy - Sioux Falls Operations | Sioux Falls | SD | Food Manufacturing311511 | 20-99 | ◐ LIKELY ACTIVE |
| ETEngineered Truss Systems, INC. | Sioux Falls | SD | Wood Product Manufacturing321214 | 20-99 | ◐ LIKELY ACTIVE |
| HMHorizontal Machining & Mfg. Inc. | Huron | SD | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| PAPrairie AquaTech Manufacturing, LLC dba Houdek Manufacturing | Volga | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| PBPremier Bee LLC | Sioux Falls | SD | Wood Product Manufacturing321999 | 20-99 | ◐ LIKELY ACTIVE |
| PDProSmiles Dental Studio | Rapid City | SD | Miscellaneous Manufacturing339116 | 20-99 | ◐ LIKELY ACTIVE |
| RBRidley Block Operations - Whitewood | Whitewood | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |