| DDSM-Firmenich | Columbia | MD | Food Manufacturing311221 | 20-99 | ◐ LIKELY ACTIVE |
| DSDS Smith | Columbia | SC | Paper Manufacturing322211 | 100-499 | ◐ LIKELY ACTIVE |
| ECEaton Corporation | Columbia | SC | Electrical Equipment, Appliance & Component Manufacturing335311 | — | ◐ LIKELY ACTIVE |
| EPElwood Prison Wine | Columbia | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| EIEquinox Innovative Systems INC | Columbia | MD | Transportation Equipment Manufacturing336411 | — | ◐ LIKELY ACTIVE |
| FFactory | Columbia | MO | Wood Product Manufacturing321992 | 20-99 | ◐ LIKELY ACTIVE |
| FSFotofinder Systems INC | Columbia | MD | Computer and Electronic Product Manufacturing334510 | — | ◐ LIKELY ACTIVE |
| FEFresh Express INC | Columbia | SC | Food Manufacturing311991 | 100-499 | ◐ LIKELY ACTIVE |
| GCGates Corporation -Columbia MO | Columbia | MO | Plastics and Rubber Products Manufacturing326299 | 100-499 | ◐ LIKELY ACTIVE |
| GNGg Nubian LLC | Columbia | MO | Machinery Manufacturing333998 | — | ◐ LIKELY ACTIVE |
| GMGrand Marche' LLC | Columbia | MD | Paper Manufacturing322291 | — | ◐ LIKELY ACTIVE |
| GGGSC - Groundworks Supply Chain | Columbia | SC | Primary Metal Manufacturing331210 | 20-99 | ◐ LIKELY ACTIVE |
| HCHahn Custom Laser Engraving LLC | Columbia | MO | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| HHeadquarters | Columbia | MD | Computer and Electronic Product Manufacturing334516 | 100-499 | ◐ LIKELY ACTIVE |
| HFHeartstone Farm & Winery, LLC | Columbia | CT | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| HCHGI Columbia TN | Columbia | TN | Chemical Manufacturing325120 | 1-19 | ◐ LIKELY ACTIVE |
| HBHohmann & Barnard (Maryland) | Columbia | MD | Fabricated Metal Product Manufacturing332312 | 1-19 | ◐ LIKELY ACTIVE |
| HIHoneywell International Inc. | Columbia | MO | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| HOHouse of Mustaine | Columbia | TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| IOIshams Ordinary, LLC | Columbia | MO | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| JCJ. C. Ford Company | Columbia | TN | Machinery Manufacturing333241 | 100-499 | ◐ LIKELY ACTIVE |
| JBJS Brewery | Columbia | MD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| JHJuice House | Columbia | TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| KKks | Columbia | SC | Food Manufacturing311111 | 100-499 | ◐ LIKELY ACTIVE |
| KHKraft Heinz Foods Company | Columbia | MO | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| LHLandmark Hospitals | Columbia | MO | Transportation Equipment Manufacturing336212 | 100-499 | ◐ LIKELY ACTIVE |
| LGLaser Graphictronics LLC | Columbia | MO | Computer and Electronic Product Manufacturing334418 | — | ◐ LIKELY ACTIVE |
| LALost Ark Distilling Company | Columbia | MD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| MMMetro Marble and Granite of Columbia DBA Central Missouri Countertops | Columbia | MO | Nonmetallic Mineral Product Manufacturing327991 | 20-99 | ◐ LIKELY ACTIVE |
| MRMid-Atlantic Regional (MAT) | Columbia | MD | Computer and Electronic Product Manufacturing334516 | 20-99 | ◐ LIKELY ACTIVE |
| MLModern Litho Columbia | Columbia | MO | Printing and Related Support Activities323111 | 1-19 | ◐ LIKELY ACTIVE |
| NMNew Millennium Building Systems, LLC. - Columbia | Columbia | SC | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| OMOld Monroe Distilling Co. | Columbia | IL | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| ODOntrak Designs INC | Columbia | TN | Transportation Equipment Manufacturing336413 | — | ◐ LIKELY ACTIVE |
| ODOversea Distillery | Columbia | MD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| OPOzark Plateau Pork, LLC | Columbia | MO | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| PLPatandjs LLC | Columbia | TN | Miscellaneous Manufacturing339940 | — | ◐ LIKELY ACTIVE |
| P8Plant 8S | Columbia | SC | Chemical Manufacturing325220 | 100-499 | ◐ LIKELY ACTIVE |
| PDPour Dog | Columbia | PA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FC"Production Facilities - Columbia, MD" | Columbia | MD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| PAPROOF Alcohol Ice Cream | Columbia | SC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| QPQ Plant | Columbia | SC | Machinery Manufacturing333241 | 20-99 | ◐ LIKELY ACTIVE |
| RWRassawek Winery | Columbia | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RAREI Automation, Inc. | Columbia | SC | Machinery Manufacturing333519 | 20-99 | ◐ LIKELY ACTIVE |
| RWRose Welding & Crane Service INC | Columbia | NC | Machinery Manufacturing333923 | — | ◐ LIKELY ACTIVE |
| SCSamtec Columbia Design Center | Columbia | SC | Computer and Electronic Product Manufacturing334417 | 20-99 | ◐ LIKELY ACTIVE |
| SHSea Hunt Boats Manufacturing Co Inc | Columbia | SC | Transportation Equipment Manufacturing336611 | 100-499 | ◐ LIKELY ACTIVE |
| SCSexton Contractors LLC | Columbia | MO | Leather and Allied Product Manufacturing316990 | — | ◐ LIKELY ACTIVE |
| SPShakespeare's Pizza, Inc. | Columbia | MO | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| SLSix20distributor LLC | Columbia | SC | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |