| BHBaxter Healthcare of Puerto Rico | Guayama | PR | Chemical Manufacturing325411 | — | ◐ LIKELY ACTIVE |
| ACAlpla Caribe INC | Guayama | PR | Plastics and Rubber Products Manufacturing326160 | 100-499 | ◐ LIKELY ACTIVE |
| CPChevron Phillips Chemical Puerto Rico Core LLC | Guayama | PR | Petroleum and Coal Products Manufacturing324110 | — | ◇ UNVERIFIED |
| CPColgate Palmolive of Puerto Rico INC | Guayama | PR | Chemical Manufacturing325611 | — | ◇ UNVERIFIED |
| LDLatas De Aluminio Ball INC | Guayama | PR | Fabricated Metal Product Manufacturing332431 | — | ◇ UNVERIFIED |
| LDLilly Del Caribe (formerly, Ipr) | Guayama | PR | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| PPPfizer Pharmaceuticals | Guayama | PR | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| TPTapi Puerto Rico INC | Guayama | PR | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| BGBaxter Guayama | Guayama | PR | Chemical Manufacturing325412 | 100-499 | ◐ LIKELY ACTIVE |
| LPLos Pasteles de La Abuela | Guayama | PR | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| PCPF Consumer Healthcare B.V.(Puerto Rico Operations) LLC | Guayama | PR | Chemical Manufacturing325412 | 500+ | ◐ LIKELY ACTIVE |
| PIPicolos INC. | Guayama | PR | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| PIPicolos INC. | Guayama | PR | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| RERodriguez Enterprises, INC | Guayama | PR | Food Manufacturing311812 | — | ◐ LIKELY ACTIVE |
| SLSanher, LLC | Guayama | PR | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| ACAlco Corporation | Guayama | PR | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| BHBaxter Health Care Sa | Guayama | PR | Miscellaneous Manufacturing339112 | — | ◇ UNVERIFIED |
| BSBiogen S.a.s | Guayama | PR | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| ECE C Quality Machine Shop LLC | Guayama | PR | Fabricated Metal Product Manufacturing332710 | — | ◇ UNVERIFIED |
| LDLilly Del Caribe INC | Guayama | PR | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| MPMedisearchs Pr INC | Guayama | PR | Miscellaneous Manufacturing339113 | — | ◇ UNVERIFIED |
| MPMulti Pallet Solutions LLC | Guayama | PR | Wood Product Manufacturing321920 | — | ◇ UNVERIFIED |
| RCRodolfo Cartagena-Colon | Guayama | PR | Food Manufacturing311999 | — | ◇ UNVERIFIED |
| RRRodolfo R Cartagena-Colon | Guayama | PR | Food Manufacturing311999 | — | ◇ UNVERIFIED |
| TPTapi Puerto Rico INC | Guayama | PR | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
