| OTOrange Tree Condominiums | Irvine | CA | Transportation Equipment Manufacturing336350 | — | ◇ UNVERIFIED |
| OMOsteon Medical | Irvine | CA | Fabricated Metal Product Manufacturing332994 | — | ◇ UNVERIFIED |
| OOtis | Irvine | CA | Transportation Equipment Manufacturing336510 | — | ◇ UNVERIFIED |
| OAOtto Aviation Group LLC | Irvine | CA | Transportation Equipment Manufacturing336413 | — | ◇ UNVERIFIED |
| PCPacific Coast Printing | Irvine | CA | Printing and Related Support Activities323111 | — | ◇ UNVERIFIED |
| PHPacific Handy Cutter INC | Irvine | CA | Fabricated Metal Product Manufacturing332212 | — | ◇ UNVERIFIED |
| PHPacific Handy Cutter INC | Irvine | CA | Primary Metal Manufacturing331511 | — | ◇ UNVERIFIED |
| PHPackard Hughes Interconnect | Irvine | CA | Computer and Electronic Product Manufacturing334417 | — | ◇ UNVERIFIED |
| PEPair Eyewear | Irvine | CA | Machinery Manufacturing333310 | — | ◇ UNVERIFIED |
| PIPanaceanano INC | Irvine | CA | Chemical Manufacturing325620 | — | ◇ UNVERIFIED |
| PAPanasonic Avionics Corporation | Irvine | CA | Transportation Equipment Manufacturing336413 | — | ◇ UNVERIFIED |
| PHParker Hannifin Corp, Control Sys Div | Irvine | CA | Transportation Equipment Manufacturing336412 | — | ◇ UNVERIFIED |
| PCParty City CORP Dba Halloween City Store #8023 | Irvine | CA | Miscellaneous Manufacturing339993 | — | ◇ UNVERIFIED |
| PRPatrick Ramsey | Irvine | CA | Miscellaneous Manufacturing339116 | — | ◇ UNVERIFIED |
| PSPetnet Solutions INC | Irvine | CA | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| PPPetunia Products, Inc. | Irvine | CA | Chemical Manufacturing325620 | — | ◇ UNVERIFIED |
| PIPhiaro, INC. | Irvine | CA | Miscellaneous Manufacturing339999 | — | ◇ UNVERIFIED |
| PRPipe Restoration Solutions INC. | Irvine | CA | Fabricated Metal Product Manufacturing332812 | — | ◇ UNVERIFIED |
| PHPlan Hold CORP | Irvine | CA | Fabricated Metal Product Manufacturing332510 | — | ◇ UNVERIFIED |
| POPrecision Offset INC | Irvine | CA | Computer and Electronic Product Manufacturing334418 | — | ◇ UNVERIFIED |
| PTPrime Tech Cabinets, INC | Irvine | CA | Furniture and Related Product Manufacturing337110 | — | ◇ UNVERIFIED |
| PIPrintronix INC | Irvine | CA | Fabricated Metal Product Manufacturing332510 | — | ◇ UNVERIFIED |
| PDProgram Data INC | Irvine | CA | Computer and Electronic Product Manufacturing334515 | — | ◇ UNVERIFIED |
| PLPrologis, L.p. | Irvine | CA | Wood Product Manufacturing321114 | — | ◇ UNVERIFIED |
| PEPropaganda E-liquid | Irvine | CA | Beverage and Tobacco Product Manufacturing312230 | — | ◇ UNVERIFIED |
| PTPro Tec Building Services | Irvine | CA | Apparel Manufacturing315999 | — | ◇ UNVERIFIED |
| PProteor | Irvine | CA | Plastics and Rubber Products Manufacturing326299 | — | ◇ UNVERIFIED |
| PHPublic Health Laboratory | Irvine | CA | Chemical Manufacturing325413 | — | ◇ UNVERIFIED |
| QIQualcomm Incorporated | Irvine | CA | Computer and Electronic Product Manufacturing334515 | — | ◇ UNVERIFIED |
| RBRamen Bros Inc | Irvine | CA | Food Manufacturing311412 | — | ◇ UNVERIFIED |
| RMRandall May International | Irvine | CA | Fabricated Metal Product Manufacturing332710 | — | ◇ UNVERIFIED |
| RERavand Enterprises INC. Assal Pastry | Irvine | CA | Plastics and Rubber Products Manufacturing326220 | — | ◇ UNVERIFIED |
| RSRaytheon Service CO | Irvine | CA | Computer and Electronic Product Manufacturing334416 | — | ◇ UNVERIFIED |
| RCR C Designs International | Irvine | CA | Leather and Allied Product Manufacturing316990 | — | ◇ UNVERIFIED |
| RLReshape Lifesciences INC | Irvine | CA | Miscellaneous Manufacturing339999 | — | ◇ UNVERIFIED |
| RMReverse Medical Corporation | Irvine | CA | Computer and Electronic Product Manufacturing334517 | — | ◇ UNVERIFIED |
| RCRichland Communities | Irvine | CA | Transportation Equipment Manufacturing336350 | — | ◇ UNVERIFIED |
| RPRidgewood/cal Power Partners L | Irvine | CA | Transportation Equipment Manufacturing336390 | — | ◇ UNVERIFIED |
| RKRiston Keller INC the Stocklan | Irvine | CA | Transportation Equipment Manufacturing336999 | — | ◇ UNVERIFIED |
| RCRockwell Collins Flight Control & Information Systems | Irvine | CA | Transportation Equipment Manufacturing336413 | — | ◇ UNVERIFIED |
| RRoka | Irvine | CA | Furniture and Related Product Manufacturing337127 | — | ◇ UNVERIFIED |
| RRoka | Irvine | CA | Miscellaneous Manufacturing339113 | — | ◇ UNVERIFIED |
| RCRoyalty Carpet Mills INC | Irvine | CA | Textile Product Mills314110 | — | ◇ UNVERIFIED |
| RLRtth, LLC | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335999 | — | ◇ UNVERIFIED |
| SASafety and Test Facility | Irvine | CA | Transportation Equipment Manufacturing336414 | — | ◇ UNVERIFIED |
| SCSand Canyon Business Center | Irvine | CA | Machinery Manufacturing333921 | — | ◇ UNVERIFIED |
| SDSan Diego Shutter CO INC | Irvine | CA | Wood Product Manufacturing321918 | — | ◇ UNVERIFIED |
 Sandisk Technologies INC | Irvine | CA | Computer and Electronic Product Manufacturing334112 | — | ◇ UNVERIFIED |
| SHSc Health Labs LLC | Irvine | CA | Computer and Electronic Product Manufacturing334516 | — | ◇ UNVERIFIED |
| SMSd Medical System INC | Irvine | CA | Chemical Manufacturing325413 | — | ◇ UNVERIFIED |
