| ISIrvine Sewing | Irvine | KY | Apparel Manufacturing315220 | 100-499 | ◐ LIKELY ACTIVE |
| JUJunkosha USA INC | Irvine | CA | Fabricated Metal Product Manufacturing332618 | — | ◐ LIKELY ACTIVE |
| KAKIP America, Inc. - California | Irvine | CA | Computer and Electronic Product Manufacturing334118 | 1-19 | ◐ LIKELY ACTIVE |
| LILaboflex, INC | Irvine | CA | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| LLedrabrands | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335122 | 100-499 | ◐ LIKELY ACTIVE |
| LCLeft Coast Brewing Co. Tasting Room Smokehouse Distillery | Irvine | CA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| LMLockheed Martin Corporation US CA Terran Orbital Irvine 50 Tech (TOC008) | Irvine | CA | Transportation Equipment Manufacturing336414 | 100-499 | ◐ LIKELY ACTIVE |
| LMLockheed Martin Corporation US CA Terran Orbital Irvine Spectrum (TOC007) | Irvine | CA | Transportation Equipment Manufacturing336414 | 100-499 | ◐ LIKELY ACTIVE |
| LILogitech Inc. d.b.a. Ultimate Ears Pro | Irvine | CA | Computer and Electronic Product Manufacturing334118 | 20-99 | ◐ LIKELY ACTIVE |
Lytos Therapeutics, INC | Irvine | CA | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| MIMaden, INC. | Irvine | CA | Machinery Manufacturing333517 | — | ◐ LIKELY ACTIVE |
| MIMCCFC Irvine | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335991 | 100-499 | ◐ LIKELY ACTIVE |
| MCMcClain Cellars | Irvine | CA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MSM-factors Storage INC | Irvine | CA | Computer and Electronic Product Manufacturing334112 | — | ◐ LIKELY ACTIVE |
| MTMicrochip Technology Inc. Irvine | Irvine | CA | Computer and Electronic Product Manufacturing334413 | 20-99 | ◐ LIKELY ACTIVE |
| MIMidmark - Irvine | Irvine | CA | Computer and Electronic Product Manufacturing334510 | 20-99 | ◐ LIKELY ACTIVE |
| MPMk Products INC | Irvine | CA | Machinery Manufacturing333992 | — | ◐ LIKELY ACTIVE |
| MIMKS Irvine | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335999 | 100-499 | ◐ LIKELY ACTIVE |
| MBMp Biomedicals LLC | Irvine | CA | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| NMNewport Meat Southern California, Inc. | Irvine | CA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| NKNihon Kohden North America Inc | Irvine | CA | Computer and Electronic Product Manufacturing334510 | 1-19 | ◐ LIKELY ACTIVE |
| NNutrawise | Irvine | CA | Chemical Manufacturing325412 | 100-499 | ◐ LIKELY ACTIVE |
| NUNXP USA, Inc Irvine | Irvine | CA | Computer and Electronic Product Manufacturing334413 | 20-99 | ◐ LIKELY ACTIVE |
| OMOptima Millwork & Stone | Irvine | CA | Furniture and Related Product Manufacturing337212 | 1-19 | ◐ LIKELY ACTIVE |
| OAOssur America's | Irvine | CA | Miscellaneous Manufacturing339113 | 100-499 | ◐ LIKELY ACTIVE |
| PAPanasonic Avionics Corporations | Irvine | CA | Transportation Equipment Manufacturing336413 | 500+ | ◐ LIKELY ACTIVE |
| PCParker-hannifin Corporation | Irvine | CA | Transportation Equipment Manufacturing336413 | — | ◐ LIKELY ACTIVE |
| PPPCB Piezotronics - Endevco Engineering | Irvine | CA | Computer and Electronic Product Manufacturing334417 | 1-19 | ◐ LIKELY ACTIVE |
| PIPpst, INC. | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335999 | — | ◐ LIKELY ACTIVE |
| R5Route 52 Moonshine, LLC | Irvine | KY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| RIRyvid INC | Irvine | CA | Transportation Equipment Manufacturing336991 | — | ◐ LIKELY ACTIVE |
| SISandisk Irvine | Irvine | CA | Computer and Electronic Product Manufacturing334112 | 100-499 | ◐ LIKELY ACTIVE |
| SISEL Irvine CA | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335314 | 1-19 | ◐ LIKELY ACTIVE |
| SPSierra Pacific Windows-Southern CA | Irvine | CA | Wood Product Manufacturing321911 | 20-99 | ◐ LIKELY ACTIVE |
| STSolar Turbines Incorporated Los Angeles District Office | Irvine | CA | Machinery Manufacturing333611 | 20-99 | ◐ LIKELY ACTIVE |
| STSps Technologies LLC | Irvine | CA | Fabricated Metal Product Manufacturing332722 | — | ◐ LIKELY ACTIVE |
| S6Store 605 | Irvine | CA | Food Manufacturing311812 | 1-19 | ◐ LIKELY ACTIVE |
| SISummit Interconnect, INC. | Irvine | CA | Computer and Electronic Product Manufacturing334412 | — | ◐ LIKELY ACTIVE |
| SBSweet Briar Properties | Irvine | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TCTaber Company, Inc | Irvine | CA | Furniture and Related Product Manufacturing337212 | 100-499 | ◐ LIKELY ACTIVE |
| TPTarsus Pharmaceuticals INC | Irvine | CA | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| TLThaeta LLC | Irvine | CA | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| TJThe Joseph Company International, INC. | Irvine | CA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| UCUS331 CA Irvine | Irvine | CA | Miscellaneous Manufacturing339113 | 500+ | ◐ LIKELY ACTIVE |
| VVVena Vitals INC | Irvine | CA | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
Vertimass, LLC | Irvine | CA | Food Manufacturing311615 | — | ◐ LIKELY ACTIVE |
| VFVictory Foam, Inc. | Irvine | CA | Plastics and Rubber Products Manufacturing326150 | 100-499 | ◐ LIKELY ACTIVE |
| VGVillage Green Foods | Irvine | CA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
Xplosion Box LLC | Irvine | CA | Paper Manufacturing322299 | — | ◐ LIKELY ACTIVE |
| XPXP Power - Irvine | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335999 | 20-99 | ◐ LIKELY ACTIVE |