| TMTdk Magnetic Tape | Irvine | CA | Transportation Equipment Manufacturing336413 | — | ◐ LIKELY ACTIVE |
| TAThales Avionics INC CA | Irvine | CA | Primary Metal Manufacturing331523 | 100-499 | ◐ LIKELY ACTIVE |
| TDThe Dot Printer | Irvine | CA | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| TIThe Irvine Company | Irvine | CA | Printing and Related Support Activities323111 | 1-19 | ◐ LIKELY ACTIVE |
| TNToro Neurovascular INC | Irvine | CA | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| VGVillage Green Foods INC. | Irvine | CA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| ZMZOLL Medical Corporation - Irvine, CA. | Irvine | CA | Computer and Electronic Product Manufacturing334517 | 20-99 | ◐ LIKELY ACTIVE |
| AMApplied Medical Resources Corporation | Irvine | CA | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| AFAti Forged Products | Irvine | CA | Fabricated Metal Product Manufacturing332112 | — | ◐ LIKELY ACTIVE |
| CICemex Irvine Plant | Irvine | CA | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| ENEllwood Natl Steel | Irvine | PA | Fabricated Metal Product Manufacturing332111 | — | ◐ LIKELY ACTIVE |
| HRHolliday Rock - Irvine | Irvine | CA | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| MCMitsubishi Chemical Carbon Fiber&composi | Irvine | CA | Chemical Manufacturing325520 | — | ◐ LIKELY ACTIVE |
| NRNational Ready Mix Concrete CO | Irvine | CA | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| SCShur-lok CORP | Irvine | CA | Fabricated Metal Product Manufacturing332722 | — | ◐ LIKELY ACTIVE |
| AAAll American Asphalt,all Amer Aggregates | Irvine | CA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
Avon Protection Systems, INC. | Irvine | CA | Miscellaneous Manufacturing339113 | — | ◇ UNVERIFIED |
| BABacon Acquisitions LLC | Irvine | CA | Chemical Manufacturing325520 | — | ◇ UNVERIFIED |
| BIBarcel/cdt INC | Irvine | CA | Primary Metal Manufacturing331222 | — | ◇ UNVERIFIED |
| CICeradyne INC 3m Company | Irvine | CA | Nonmetallic Mineral Product Manufacturing327999 | — | ◇ UNVERIFIED |
| CECheek Engineering | Irvine | CA | Fabricated Metal Product Manufacturing332119 | — | ◇ UNVERIFIED |
| DPDba Par Pharmaceutical | Irvine | CA | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| EIEnthone INC | Irvine | CA | Chemical Manufacturing325188 | — | ◇ UNVERIFIED |
| HCHenkel Corporation | Irvine | CA | Chemical Manufacturing325520 | — | ◇ UNVERIFIED |
| KEKaiser Electroprecision | Irvine | CA | Computer and Electronic Product Manufacturing334511 | — | ◇ UNVERIFIED |
| KAKyowa America CORP | Irvine | CA | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| MAMarcums Auto Sales | Irvine | KY | Transportation Equipment Manufacturing336211 | — | ◇ UNVERIFIED |
| MUMarukome USA | Irvine | CA | Miscellaneous Manufacturing339112 | — | ◇ UNVERIFIED |
| MOMeggit Orange County INC | Irvine | CA | Computer and Electronic Product Manufacturing334519 | — | ◇ UNVERIFIED |
| NRNh Research | Irvine | CA | Computer and Electronic Product Manufacturing334515 | 20-99 | ◇ UNVERIFIED |
| OIOmniprint International | Irvine | CA | Chemical Manufacturing325910 | — | ◇ UNVERIFIED |
| PHParker Hannifin CORP | Irvine | CA | Transportation Equipment Manufacturing336411 | — | ◇ UNVERIFIED |
| PDPrc Desoto International, INC. (dba Ppg Aerospace) | Irvine | CA | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
| RDRacal Dana Instruments INC | Irvine | CA | Computer and Electronic Product Manufacturing334515 | — | ◇ UNVERIFIED |
| RERicoh Electronics INC | Irvine | CA | Chemical Manufacturing325992 | — | ◇ UNVERIFIED |
| SCSanmina Corporation | Irvine | CA | Computer and Electronic Product Manufacturing334412 | — | ◇ UNVERIFIED |
| SSSeal Science INC | Irvine | CA | Plastics and Rubber Products Manufacturing326291 | — | ▲ REPORTED CLOSED |
| SLSmart Levels Media | Irvine | CA | Printing and Related Support Activities323111 | — | ◇ UNVERIFIED |
| SBSorin Biomedical INC | Irvine | CA | Miscellaneous Manufacturing339112 | — | ◇ UNVERIFIED |
| TCT C Cosmotronic INC Dba Cosmotronic | Irvine | CA | Computer and Electronic Product Manufacturing334412 | — | ◇ UNVERIFIED |
| TFTropitone Furniture CO INC | Irvine | CA | Furniture and Related Product Manufacturing337121 | — | ◇ UNVERIFIED |
| VVVerdict Vapors | Irvine | CA | Chemical Manufacturing325411 | — | ◇ UNVERIFIED |
| ZCZygo Corporation | Irvine | CA | Machinery Manufacturing333310 | — | ◇ UNVERIFIED |
| AIAddtac INC | Irvine | CA | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| ASAdvanced Sterilization Products, Irvine | Irvine | CA | Miscellaneous Manufacturing339112 | 500+ | ◐ LIKELY ACTIVE |
| AIAerospace Irvine Ca | Irvine | CA | Fabricated Metal Product Manufacturing332912 | 100-499 | ◐ LIKELY ACTIVE |
| AIAerospace Irvine FSD | Irvine | CA | Transportation Equipment Manufacturing336413 | 100-499 | ◐ LIKELY ACTIVE |
| AIAerospace Irvine MFCD | Irvine | CA | Transportation Equipment Manufacturing336412 | 500+ | ◐ LIKELY ACTIVE |
| ASAmica Software | Irvine | CA | Chemical Manufacturing325910 | 20-99 | ◐ LIKELY ACTIVE |
| ALAmpx LLC | Irvine | CA | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |