| MBMp Biomedicals LLC | Irvine | CA | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| NMNewport Meat Southern California, Inc. | Irvine | CA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| NKNihon Kohden North America Inc | Irvine | CA | Computer and Electronic Product Manufacturing334510 | 1-19 | ◐ LIKELY ACTIVE |
| NNutrawise | Irvine | CA | Chemical Manufacturing325412 | 100-499 | ◐ LIKELY ACTIVE |
| NUNXP USA, Inc Irvine | Irvine | CA | Computer and Electronic Product Manufacturing334413 | 20-99 | ◐ LIKELY ACTIVE |
| OMOptima Millwork & Stone | Irvine | CA | Furniture and Related Product Manufacturing337212 | 1-19 | ◐ LIKELY ACTIVE |
| OAOssur America's | Irvine | CA | Miscellaneous Manufacturing339113 | 100-499 | ◐ LIKELY ACTIVE |
| PAPanasonic Avionics Corporations | Irvine | CA | Transportation Equipment Manufacturing336413 | 500+ | ◐ LIKELY ACTIVE |
| PPPCB Piezotronics - Endevco Engineering | Irvine | CA | Computer and Electronic Product Manufacturing334417 | 1-19 | ◐ LIKELY ACTIVE |
| PIPpst, INC. | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335999 | — | ◐ LIKELY ACTIVE |
Rje International, INC. | Irvine | CA | Computer and Electronic Product Manufacturing334511 | — | ◐ LIKELY ACTIVE |
| R5Route 52 Moonshine, LLC | Irvine | KY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SISandisk Irvine | Irvine | CA | Computer and Electronic Product Manufacturing334112 | 100-499 | ◐ LIKELY ACTIVE |
| SISEL Irvine CA | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335314 | 1-19 | ◐ LIKELY ACTIVE |
| SPSierra Pacific Windows-Southern CA | Irvine | CA | Wood Product Manufacturing321911 | 20-99 | ◐ LIKELY ACTIVE |
| STSolar Turbines Incorporated Los Angeles District Office | Irvine | CA | Machinery Manufacturing333611 | 20-99 | ◐ LIKELY ACTIVE |
| S6Store 605 | Irvine | CA | Food Manufacturing311812 | 1-19 | ◐ LIKELY ACTIVE |
| SISummit Interconnect, INC. | Irvine | CA | Computer and Electronic Product Manufacturing334412 | — | ▲ REPORTED CLOSED |
| SBSweet Briar Properties | Irvine | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TCTaber Company, Inc | Irvine | CA | Furniture and Related Product Manufacturing337212 | 100-499 | ◐ LIKELY ACTIVE |
| TLThaeta LLC | Irvine | CA | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| TJThe Joseph Company International, INC. | Irvine | CA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| UCUS331 CA Irvine | Irvine | CA | Miscellaneous Manufacturing339113 | 500+ | ◐ LIKELY ACTIVE |
| VFVictory Foam, Inc. | Irvine | CA | Plastics and Rubber Products Manufacturing326150 | 100-499 | ◐ LIKELY ACTIVE |
| XPXP Power - Irvine | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335999 | 20-99 | ◐ LIKELY ACTIVE |
| ZCZOLL CMS TherOx | Irvine | CA | Computer and Electronic Product Manufacturing334510 | 20-99 | ◐ LIKELY ACTIVE |
| AIA-info INC | Irvine | CA | Computer and Electronic Product Manufacturing334515 | — | ◐ LIKELY ACTIVE |
| CICummins INC | Irvine | CA | Machinery Manufacturing333618 | — | ◐ LIKELY ACTIVE |
| RIRyvid INC | Irvine | CA | Transportation Equipment Manufacturing336991 | — | ◐ LIKELY ACTIVE |
| TPTarsus Pharmaceuticals INC | Irvine | CA | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| ATAbstrax Tech INC | Irvine | CA | Chemical Manufacturing325620 | 20-99 | ◇ UNVERIFIED |
| AIAllergan INC | Irvine | CA | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| AIAquatec International INC | Irvine | CA | Machinery Manufacturing333911 | — | ◇ UNVERIFIED |
| BCBenchmark Cosmetic Laboratories | Irvine | CA | Chemical Manufacturing325620 | — | ◇ UNVERIFIED |
| BBiolase | Irvine | CA | Miscellaneous Manufacturing339114 | — | ◇ UNVERIFIED |
| CGCapital Group Companies, INC. | Irvine | CA | Food Manufacturing311225 | — | ◇ UNVERIFIED |
| CLCavium LLC | Irvine | CA | Computer and Electronic Product Manufacturing334413 | — | ◇ UNVERIFIED |
| CDCrenshaw Die and Manufacturing Corporation | Irvine | CA | Fabricated Metal Product Manufacturing332116 | — | ◇ UNVERIFIED |
| DHDrybar Holdings LLC | Irvine | CA | Furniture and Related Product Manufacturing337127 | — | ◇ UNVERIFIED |
| FIFreedom Innovations LLC | Irvine | CA | Computer and Electronic Product Manufacturing334517 | 100-499 | ◇ UNVERIFIED |
| FFreshends | Irvine | CA | Paper Manufacturing322220 | 1-19 | ◇ UNVERIFIED |
| ITIo Therapeutics, INC. | Irvine | CA | Chemical Manufacturing325412 | 1-19 | ◇ UNVERIFIED |
| JCJmw Cabinets, INC. | Irvine | CA | Furniture and Related Product Manufacturing337110 | — | ◇ UNVERIFIED |
| MSMarvell Semiconductor, INC. | Irvine | CA | Computer and Electronic Product Manufacturing334413 | — | ◇ UNVERIFIED |
| MMedtronic | Irvine | CA | Miscellaneous Manufacturing339113 | — | ◇ UNVERIFIED |
| PMPas Mro, INC. | Irvine | CA | Transportation Equipment Manufacturing336411 | 1-19 | ◇ UNVERIFIED |
| PSPrecision Stamping & Tool INC | Irvine | CA | Fabricated Metal Product Manufacturing332431 | 1-19 | ◇ UNVERIFIED |
| QIQWW Inc. | Irvine | CA | Apparel Manufacturing315990 | 1-19 | ◇ UNVERIFIED |
| SLSdi LLC | Irvine | CA | Wood Product Manufacturing321999 | 1-19 | ◇ UNVERIFIED |
| SJSt John Knits International INC | Irvine | CA | Textile Mills313240 | — | ◇ UNVERIFIED |