| ENEllwood Natl Forge | Irvine | PA | Chemical Manufacturing325412 | 100-499 | ◐ LIKELY ACTIVE |
| IBIrvine Batch Plant | Irvine | CA | Petroleum and Coal Products Manufacturing324121 | 1-19 | ◐ LIKELY ACTIVE |
| MMedennium | Irvine | CA | Miscellaneous Manufacturing339115 | 1-19 | ◐ LIKELY ACTIVE |
| BHBaxter Healthcare CORP Bentley Div | Irvine | CA | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| CLCp-carrillo LLC | Irvine | CA | Transportation Equipment Manufacturing336310 | 100-499 | ◐ LIKELY ACTIVE |
| DIDynalloy, INC. | Irvine | CA | Primary Metal Manufacturing331491 | 20-99 | ◐ LIKELY ACTIVE |
| JIJsn Industries INC | Irvine | CA | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
| LHLumitron Holdings INC | Irvine | CA | Computer and Electronic Product Manufacturing334517 | 20-99 | ◐ LIKELY ACTIVE |
Nanovea, INC. | Irvine | CA | Computer and Electronic Product Manufacturing334516 | 20-99 | ◐ LIKELY ACTIVE |
| STSdc Technologies INC | Irvine | CA | Chemical Manufacturing325211 | — | ◐ LIKELY ACTIVE |
3 Day Blinds LLC | Irvine | CA | Furniture and Related Product Manufacturing337920 | — | ◐ LIKELY ACTIVE |
Federal Custom Cable, LLC | Irvine | CA | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| IEIrvine Electronics LLC | Irvine | CA | Computer and Electronic Product Manufacturing334412 | 100-499 | ◐ LIKELY ACTIVE |
| MPMk Products INC | Irvine | CA | Machinery Manufacturing333992 | 20-99 | ◐ LIKELY ACTIVE |
| NPNexgen Pharma INC | Irvine | CA | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |
Overture Resurfacing INC | Irvine | CA | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| STSPS TECHNOLOGIES, LLC DBA SHUR-LOK Company | Irvine | CA | Fabricated Metal Product Manufacturing332722 | 100-499 | ◐ LIKELY ACTIVE |
| SMStarboard Medical INC. | Irvine | CA | Miscellaneous Manufacturing339112 | 1-19 | ◐ LIKELY ACTIVE |
Teradek LLC | Irvine | CA | Computer and Electronic Product Manufacturing334310 | — | ◐ LIKELY ACTIVE |
Tricom Research, INC. | Irvine | CA | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| VVVena Vitals INC | Irvine | CA | Miscellaneous Manufacturing339112 | 1-19 | ◐ LIKELY ACTIVE |
Vubiq Networks, INC. | Irvine | CA | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| SHSwift Health Systems in Dba Inbrace | Irvine | CA | Miscellaneous Manufacturing339114 | 20-99 | ◐ LIKELY ACTIVE |
| ARAlcon Research LTD | Irvine | CA | Miscellaneous Manufacturing339112 | 500+ | ◐ LIKELY ACTIVE |
| AIAnduril Industries, INC. | Irvine | CA | Computer and Electronic Product Manufacturing334511 | — | ◐ LIKELY ACTIVE |
Avon Protection Systems, INC | Irvine | CA | Miscellaneous Manufacturing339113 | 100-499 | ◐ LIKELY ACTIVE |
| BLBiogennix LLC | Irvine | CA | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |
| BIBiomerica INC | Irvine | CA | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |
Bio-rad Laboratories | Irvine | CA | Chemical Manufacturing325413 | — | ◐ LIKELY ACTIVE |
| BWBiosense Webster | Irvine | CA | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| BPBowerman Power Lfg, LLC | Irvine | CA | Miscellaneous Manufacturing339114 | — | ◐ LIKELY ACTIVE |
| BSBridgemed Solutions INC | Irvine | CA | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| CCovidien | Irvine | CA | Miscellaneous Manufacturing339112 | 500+ | ◐ LIKELY ACTIVE |
| CGCtc Global | Irvine | CA | Electrical Equipment, Appliance & Component Manufacturing335931 | — | ◐ LIKELY ACTIVE |
| DIDiality INC | Irvine | CA | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| DTDona Tina LLC | Irvine | CA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| ECEaton Corporation | Irvine | CA | Fabricated Metal Product Manufacturing332912 | — | ◐ LIKELY ACTIVE |
Edwards Lifesciences | Irvine | CA | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| FLFluxergy LLC | Irvine | CA | Computer and Electronic Product Manufacturing334516 | — | ◐ LIKELY ACTIVE |
| GMGlobal Metal Solutions, INC | Irvine | CA | Fabricated Metal Product Manufacturing332813 | — | ◐ LIKELY ACTIVE |
| HIHoriba Instruments INC | Irvine | CA | Plastics and Rubber Products Manufacturing326299 | 20-99 | ◐ LIKELY ACTIVE |
| IVInnova Vascular INC | Irvine | CA | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| IIrvine | Irvine | CA | Printing and Related Support Activities323111 | 1-19 | ◐ LIKELY ACTIVE |
| IDIrvine Dental | Irvine | CA | Miscellaneous Manufacturing339114 | 100-499 | ◐ LIKELY ACTIVE |
| IMIrvine Monarch Labs LLC | Irvine | CA | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |
| INIrvine Neomend | Irvine | CA | Miscellaneous Manufacturing339112 | 20-99 | ◐ LIKELY ACTIVE |
| ILIsaacs Lumber INC | Irvine | KY | Wood Product Manufacturing321113 | — | ◐ LIKELY ACTIVE |
| JCJanteq CORP | Irvine | CA | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| JIJsn Industries | Irvine | CA | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
| MLMedalliance LLC | Irvine | CA | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |