| CMCe-ri-ss Materials LLC | Knoxville | TN | Primary Metal Manufacturing331524 | — | ◐ LIKELY ACTIVE |
| CRCMC Rebar Knoxville | Knoxville | TN | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| CPConsumer Packaging Knoxville F | Knoxville | TN | Paper Manufacturing322212 | 100-499 | ◐ LIKELY ACTIVE |
| CCCopper Cellar Corp | Knoxville | TN | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| CBCrafty Bastard Brewery, INC. | Knoxville | TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
Crane 1 Services - Knoxville | Knoxville | TN | Machinery Manufacturing333923 | 1-19 | ◐ LIKELY ACTIVE |
| CRCrown Rose Estate | Knoxville | MD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CMCuts Manufacturing, INC. | Knoxville | TN | Machinery Manufacturing333120 | — | ▲ REPORTED CLOSED |
| DBDe Boer Winery | Knoxville | IA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| DSDempster Sales, INC. | Knoxville | TN | Transportation Equipment Manufacturing336211 | — | ◐ LIKELY ACTIVE |
| DZDrop Zone Distilling Company, LLC | Knoxville | TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| DIDyke Industries, Inc | Knoxville | TN | Wood Product Manufacturing321911 | 20-99 | ◐ LIKELY ACTIVE |
| ESEdwin + Sons Cocktail Co. | Knoxville | TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| ECElemental Composites LLC | Knoxville | TN | Textile Mills313230 | — | ◐ LIKELY ACTIVE |
| EKElo KOC | Knoxville | TN | Computer and Electronic Product Manufacturing334118 | 20-99 | ◐ LIKELY ACTIVE |
| EOEndolimb Orthoplastic Solutions, INC. | Knoxville | TN | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| EEETI Elkhart / Tri-Went Industrial | Knoxville | TN | Fabricated Metal Product Manufacturing332996 | 20-99 | ◐ LIKELY ACTIVE |
| FBFlock Beer & Wine | Knoxville | TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FBFrench Broad Iron Works CORP. | Knoxville | TN | Machinery Manufacturing333992 | — | ◐ LIKELY ACTIVE |
| FMFresenius Medical Care | Knoxville | TN | Chemical Manufacturing325412 | 100-499 | ◐ LIKELY ACTIVE |
| FEFrog Eye Vineyard | Knoxville | MD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FOFruits of Our Labor Vineyards and Winery, LLC | Knoxville | IA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| GCGypsy Circus Cider Company, LLC | Knoxville | TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| H5HEC 5501 Island River Drive | Knoxville | TN | Fabricated Metal Product Manufacturing332420 | 1-19 | ◐ LIKELY ACTIVE |
| HKHGI Knoxville River | Knoxville | TN | Chemical Manufacturing325120 | 1-19 | ◐ LIKELY ACTIVE |
| IFIndustrial Fabrication Resources INC. | Knoxville | TN | Machinery Manufacturing333613 | — | ▲ REPORTED CLOSED |
| IMInternational Motors, LLC | Knoxville | TN | Transportation Equipment Manufacturing336120 | — | ◐ LIKELY ACTIVE |
| JJJ & J Machine & Tool, INC. | Knoxville | TN | Fabricated Metal Product Manufacturing332721 | — | ◐ LIKELY ACTIVE |
| KIKanadevia Inova U.s.a. Holding INC. | Knoxville | TN | Chemical Manufacturing325120 | — | ◐ LIKELY ACTIVE |
| KKnoxville | Knoxville | TN | Beverage and Tobacco Product Manufacturing312120 | 1-19 | ◐ LIKELY ACTIVE |
| KBKnoxville Box | Knoxville | TN | Paper Manufacturing322211 | 1-19 | ◐ LIKELY ACTIVE |
| KBKnoxville Branch | Knoxville | TN | Machinery Manufacturing333995 | 1-19 | ◐ LIKELY ACTIVE |
| KPKnoxville Pkg Tn | Knoxville | TN | Beverage and Tobacco Product Manufacturing312111 | 100-499 | ◐ LIKELY ACTIVE |
| KTKnoxville, TN | Knoxville | TN | Transportation Equipment Manufacturing336510 | 1-19 | ◐ LIKELY ACTIVE |
| KWKnox Whiskey Works | Knoxville | TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| LBLa Bella Madera | Knoxville | TN | Furniture and Related Product Manufacturing337211 | — | ◐ LIKELY ACTIVE |
| LSLenox Solutions LLC | Knoxville | TN | Miscellaneous Manufacturing339950 | — | ◐ LIKELY ACTIVE |
| LTLiberty Tire Recycling - Knoxville, TN | Knoxville | TN | Plastics and Rubber Products Manufacturing326299 | 20-99 | ◐ LIKELY ACTIVE |
| MPMachined Products Co., INC. | Knoxville | TN | Fabricated Metal Product Manufacturing332721 | — | ◐ LIKELY ACTIVE |
| MPMagnolia Provision Co., Inc. | Knoxville | TN | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| MSMda Systems LLC | Knoxville | TN | Computer and Electronic Product Manufacturing334418 | — | ◐ LIKELY ACTIVE |
| MDMelas Defense Systems, INC. | Knoxville | TN | Fabricated Metal Product Manufacturing332994 | — | ◐ LIKELY ACTIVE |
| MMIRATECH_Knoxville | Knoxville | TN | Machinery Manufacturing333413 | 20-99 | ◐ LIKELY ACTIVE |
| MCMulti-Color Corporation - F & B Knoxville TN | Knoxville | TN | Printing and Related Support Activities323111 | 100-499 | ◐ LIKELY ACTIVE |
| NWNearwood Winery | Knoxville | IA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| NNobelus | Knoxville | TN | Plastics and Rubber Products Manufacturing326112 | 20-99 | ◐ LIKELY ACTIVE |
| OFOrlowski Family Vineyards | Knoxville | MD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| PSPetnet Solutions, INC. | Knoxville | TN | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| PMPost Modern Distilling, LLC | Knoxville | TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| PIPulcir INC | Knoxville | TN | Machinery Manufacturing333415 | — | ◐ LIKELY ACTIVE |