| GDGingerwolf Distillery | Middletown | VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GEGray Elephant & YAH-Vino | Middletown | PA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| HLHega LLC | Middletown | NY | Chemical Manufacturing325611 | — | ◐ LIKELY ACTIVE |
| HWHester Winery | Middletown | DE | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| HHrimt02 | Middletown | RI | Computer and Electronic Product Manufacturing334511 | 20-99 | ◐ LIKELY ACTIVE |
| HVHudson Valley | Middletown | NY | Food Manufacturing311520 | 1-19 | ◐ LIKELY ACTIVE |
| HSHydro Service & Supplies, INC. | Middletown | CT | Machinery Manufacturing333310 | — | ◐ LIKELY ACTIVE |
| JBJAKL Beer Works | Middletown | DE | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| JMJBT Marel - Avure Technologies | Middletown | OH | Machinery Manufacturing333241 | 20-99 | ◐ LIKELY ACTIVE |
| KWKadence Wine Co. | Middletown | NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MEManufacturers Equipment CO | Middletown | OH | Fabricated Metal Product Manufacturing332618 | — | ◐ LIKELY ACTIVE |
| MVMazzaroth Vineyard | Middletown | MD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MLMetal-Matic, LLC Middletown Plant | Middletown | OH | Primary Metal Manufacturing331210 | 20-99 | ◐ LIKELY ACTIVE |
| MCMiddletown CC AKS Steel | Middletown | OH | Machinery Manufacturing333923 | 20-99 | ◐ LIKELY ACTIVE |
| MNMiddletown NY Millwork | Middletown | NY | Furniture and Related Product Manufacturing337212 | 20-99 | ◐ LIKELY ACTIVE |
| MOMiddletown, Oh | Middletown | OH | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| MPMiddletown Plant | Middletown | NY | Food Manufacturing311919 | 100-499 | ◐ LIKELY ACTIVE |
| MPMiddletown Plant 181 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| MPMiddletown Plant 408 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| MRMiddletown Recycling | Middletown | OH | Transportation Equipment Manufacturing336510 | 1-19 | ◐ LIKELY ACTIVE |
| MCMiner - Central State | Middletown | PA | Fabricated Metal Product Manufacturing332321 | 20-99 | ◐ LIKELY ACTIVE |
| MMMishka Mead LLC | Middletown | CT | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| NBName Brandt Distilling | Middletown | OH | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| NYNew York Warehouse | Middletown | NY | Miscellaneous Manufacturing339112 | 1-19 | ◐ LIKELY ACTIVE |
| NBNRG Bakery | Middletown | RI | Food Manufacturing311812 | 1-19 | ◐ LIKELY ACTIVE |
| NLN-Stock, LLC | Middletown | OH | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| OCOrange County Elevator LLC | Middletown | NY | Machinery Manufacturing333921 | — | ◐ LIKELY ACTIVE |
| PRPHLCP Rinker Materials | Middletown | DE | Nonmetallic Mineral Product Manufacturing327332 | 20-99 | ◐ LIKELY ACTIVE |
| PCPhoenix Contact USA - Commerce Drive | Middletown | PA | Furniture and Related Product Manufacturing337215 | 1-19 | ◐ LIKELY ACTIVE |
| PIPolycraft Industries | Middletown | NY | Plastics and Rubber Products Manufacturing326112 | 100-499 | ◐ LIKELY ACTIVE |
| PMPp Middletown Holdings, LLC | Middletown | CT | Fabricated Metal Product Manufacturing332993 | — | ◐ LIKELY ACTIVE |
| PAPratt and Whitney Advanced Coating Technologies | Middletown | NY | Fabricated Metal Product Manufacturing332812 | 100-499 | ◐ LIKELY ACTIVE |
| PWPratt & Whitney Amercon | Middletown | PA | Transportation Equipment Manufacturing336412 | 100-499 | ◐ LIKELY ACTIVE |
| PWPratt & Whitney Middletown | Middletown | CT | Transportation Equipment Manufacturing336412 | 500+ | ◐ LIKELY ACTIVE |
| QHQuaker Houghton MDT | Middletown | OH | Petroleum and Coal Products Manufacturing324191 | 20-99 | ◐ LIKELY ACTIVE |
| RLRdzm, LLC | Middletown | IA | Fabricated Metal Product Manufacturing332993 | — | ◐ LIKELY ACTIVE |
| RVRosina's Vineyard | Middletown | NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RCRtx Corporation | Middletown | CT | Transportation Equipment Manufacturing336412 | — | ◐ LIKELY ACTIVE |
| SSeacorp | Middletown | RI | Computer and Electronic Product Manufacturing334511 | 500+ | ◐ LIKELY ACTIVE |
| SMSeven Mile Winery LLC | Middletown | OH | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SCSnyder Concrete Products - Yard 7 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327331 | 20-99 | ◐ LIKELY ACTIVE |
| SRSP Richards Company Middletown | Middletown | NY | Paper Manufacturing322230 | 20-99 | ◐ LIKELY ACTIVE |
| SISprocket Industries LLC | Middletown | RI | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| TCTe Connectivity Corporation | Middletown | PA | Computer and Electronic Product Manufacturing334417 | — | ◐ LIKELY ACTIVE |
Te Connectivity Corporation | Middletown | PA | Computer and Electronic Product Manufacturing334417 | — | ◐ LIKELY ACTIVE |
| TVThe Vineyard at Hershey, LLC | Middletown | PA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TWThe White Dog Distilling Company | Middletown | OH | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| TWTimeless Wines, L.l.c. | Middletown | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| WOWillow Oaks LLC | Middletown | MD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| ZBZeager Bros., Inc - Middletown | Middletown | PA | Wood Product Manufacturing321999 | 20-99 | ◐ LIKELY ACTIVE |