| CSCleveland-cliffs Steel CORP | Middletown | OH | Primary Metal Manufacturing331110 | 500+ | ● ACTIVE |
| PCPilot Chemical CO Middletown Ohio Facility | Middletown | OH | Chemical Manufacturing325611 | 20-99 | ● ACTIVE |
| SESuncoke Energy Middletown Operations | Middletown | OH | Petroleum and Coal Products Manufacturing324199 | 20-99 | ● ACTIVE |
Granger Plastics CO | Middletown | OH | Plastics and Rubber Products Manufacturing326121 | — | ● ACTIVE |
Interscope Manufacturing INC | Middletown | OH | Machinery Manufacturing333514 | — | ● ACTIVE |
Magellan Aerospace, Middletown, INC | Middletown | OH | Transportation Equipment Manufacturing336412 | 100-499 | ● ACTIVE |
Amteco INC | Middletown | OH | Machinery Manufacturing333994 | — | ● ACTIVE |
Daubenmire's Printing Company, LLC | Middletown | OH | Printing and Related Support Activities323111 | — | ● ACTIVE |
Hanger Prosthetics & Orthotics, INC | Middletown | OH | Miscellaneous Manufacturing339113 | — | ● ACTIVE |
Independent Sheet Metal LLC | Middletown | OH | Fabricated Metal Product Manufacturing332322 | — | ● ACTIVE |
Middletown Industrial Technologies, LLC | Middletown | OH | Fabricated Metal Product Manufacturing332710 | — | ● ACTIVE |
| BCBluescope Coated Products | Middletown | OH | Fabricated Metal Product Manufacturing332812 | 100-499 | ◐ LIKELY ACTIVE |
| APAkers Packaging Service INC * | Middletown | OH | Paper Manufacturing322121 | 100-499 | ◐ LIKELY ACTIVE |
| IPInternational Paper, Middletown Container | Middletown | OH | Paper Manufacturing322211 | 100-499 | ◐ LIKELY ACTIVE |
| QCQuaker Chemical CORP | Middletown | OH | Petroleum and Coal Products Manufacturing324191 | — | ◐ LIKELY ACTIVE |
| SMShepherd Middletown Company | Middletown | OH | Chemical Manufacturing325180 | — | ◐ LIKELY ACTIVE |
| WPWausau Paper Towel & Tissue LLC | Middletown | OH | Paper Manufacturing322120 | — | ◐ LIKELY ACTIVE |
| SSSmurfit Stone Container CORP | Middletown | OH | Paper Manufacturing322130 | — | ◇ UNVERIFIED |
| SIStein INC | Middletown | OH | Nonmetallic Mineral Product Manufacturing327992 | — | ◇ UNVERIFIED |
| 6C605 Clark Street | Middletown | OH | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| AMAds Manufacturing Ohio LLC | Middletown | OH | Fabricated Metal Product Manufacturing332119 | 20-99 | ◐ LIKELY ACTIVE |
| CSCleveland-Cliffs Steel Research & Innovation Center | Middletown | OH | Primary Metal Manufacturing331110 | 20-99 | ◐ LIKELY ACTIVE |
| HCHoney Cell INC. Midwest | Middletown | OH | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| APAir Products, Middletown,oh | Middletown | OH | Chemical Manufacturing325120 | — | ◇ UNVERIFIED |
| BPBarrett Paving - Middletown Asphalt | Middletown | OH | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| CTCrystal Tissue CO | Middletown | OH | Paper Manufacturing322121 | — | ◇ UNVERIFIED |
| HCHytek Coatings, INC. (1409010844) | Middletown | OH | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
| RCRps Composites Ohio, INC. | Middletown | OH | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| SPSorg Paper CO. | Middletown | OH | Paper Manufacturing322120 | — | ◇ UNVERIFIED |
| CDCincinnati Distilling | Middletown | OH | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCColdwater Creek Winery | Middletown | OH | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCCrane Consumables.com | Middletown | OH | Paper Manufacturing322299 | 20-99 | ◐ LIKELY ACTIVE |
| EDEquipment Depot Ohio, Inc - Middletown | Middletown | OH | Machinery Manufacturing333924 | 1-19 | ◐ LIKELY ACTIVE |
| JMJBT Marel - Avure Technologies | Middletown | OH | Machinery Manufacturing333241 | 20-99 | ◐ LIKELY ACTIVE |
| MEManufacturers Equipment CO | Middletown | OH | Fabricated Metal Product Manufacturing332618 | — | ◐ LIKELY ACTIVE |
| MLMetal-Matic, LLC Middletown Plant | Middletown | OH | Primary Metal Manufacturing331210 | 20-99 | ◐ LIKELY ACTIVE |
| MCMiddletown CC AKS Steel | Middletown | OH | Machinery Manufacturing333923 | 20-99 | ◐ LIKELY ACTIVE |
| MOMiddletown, Oh | Middletown | OH | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| MPMiddletown Plant 181 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| MPMiddletown Plant 408 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| MRMiddletown Recycling | Middletown | OH | Transportation Equipment Manufacturing336510 | 1-19 | ◐ LIKELY ACTIVE |
| NBName Brandt Distilling | Middletown | OH | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| NLN-Stock, LLC | Middletown | OH | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| QHQuaker Houghton MDT | Middletown | OH | Petroleum and Coal Products Manufacturing324191 | 20-99 | ◐ LIKELY ACTIVE |
| SMSeven Mile Winery LLC | Middletown | OH | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SCSnyder Concrete Products - Yard 7 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327331 | 20-99 | ◐ LIKELY ACTIVE |
| TWThe White Dog Distilling Company | Middletown | OH | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| AIArmco INC Research & Technology Vim Laboratory | Middletown | OH | Primary Metal Manufacturing331111 | — | ◇ UNVERIFIED |
| BPBarrett Paving Materials INC (1483000531) | Middletown | OH | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| CRCentral Ready Mix, LLC | Middletown | OH | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |