| BCBluescope Coated Products | Middletown | OH | Fabricated Metal Product Manufacturing332812 | 100-499 | ◐ LIKELY ACTIVE |
| APAkers Packaging Service INC * | Middletown | OH | Paper Manufacturing322121 | 100-499 | ◐ LIKELY ACTIVE |
| IPInternational Paper, Middletown Container | Middletown | OH | Paper Manufacturing322211 | 100-499 | ◐ LIKELY ACTIVE |
| QCQuaker Chemical CORP | Middletown | OH | Petroleum and Coal Products Manufacturing324191 | — | ◐ LIKELY ACTIVE |
| SMShepherd Middletown Company | Middletown | OH | Chemical Manufacturing325180 | — | ◐ LIKELY ACTIVE |
| WPWausau Paper Towel & Tissue LLC | Middletown | OH | Paper Manufacturing322120 | — | ◐ LIKELY ACTIVE |
| 6C605 Clark Street | Middletown | OH | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| AMAds Manufacturing Ohio LLC | Middletown | OH | Fabricated Metal Product Manufacturing332119 | 20-99 | ◐ LIKELY ACTIVE |
| CSCleveland-Cliffs Steel Research & Innovation Center | Middletown | OH | Primary Metal Manufacturing331110 | 20-99 | ◐ LIKELY ACTIVE |
| HCHoney Cell INC. Midwest | Middletown | OH | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| CDCincinnati Distilling | Middletown | OH | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCColdwater Creek Winery | Middletown | OH | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCCrane Consumables.com | Middletown | OH | Paper Manufacturing322299 | 20-99 | ◐ LIKELY ACTIVE |
| EDEquipment Depot Ohio, Inc - Middletown | Middletown | OH | Machinery Manufacturing333924 | 1-19 | ◐ LIKELY ACTIVE |
| JMJBT Marel - Avure Technologies | Middletown | OH | Machinery Manufacturing333241 | 20-99 | ◐ LIKELY ACTIVE |
| MEManufacturers Equipment CO | Middletown | OH | Fabricated Metal Product Manufacturing332618 | — | ◐ LIKELY ACTIVE |
| MLMetal-Matic, LLC Middletown Plant | Middletown | OH | Primary Metal Manufacturing331210 | 20-99 | ◐ LIKELY ACTIVE |
| MCMiddletown CC AKS Steel | Middletown | OH | Machinery Manufacturing333923 | 20-99 | ◐ LIKELY ACTIVE |
| MOMiddletown, Oh | Middletown | OH | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| MPMiddletown Plant 181 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| MPMiddletown Plant 408 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| MRMiddletown Recycling | Middletown | OH | Transportation Equipment Manufacturing336510 | 1-19 | ◐ LIKELY ACTIVE |
| NBName Brandt Distilling | Middletown | OH | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| NLN-Stock, LLC | Middletown | OH | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| QHQuaker Houghton MDT | Middletown | OH | Petroleum and Coal Products Manufacturing324191 | 20-99 | ◐ LIKELY ACTIVE |
| SMSeven Mile Winery LLC | Middletown | OH | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SCSnyder Concrete Products - Yard 7 | Middletown | OH | Nonmetallic Mineral Product Manufacturing327331 | 20-99 | ◐ LIKELY ACTIVE |
| TWThe White Dog Distilling Company | Middletown | OH | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |