| DPDart Polymers INC | Owensboro | KY | Chemical Manufacturing325211 | 100-499 | ◐ LIKELY ACTIVE |
| HHHausner Hard-chrome of Kentucky | Owensboro | KY | Fabricated Metal Product Manufacturing332813 | 100-499 | ◐ LIKELY ACTIVE |
| KCKimberly-clark Corporation | Owensboro | KY | Paper Manufacturing322120 | — | ◐ LIKELY ACTIVE |
| OGOwensboro Grain Biodiesel LLC Biodiesel Plant | Owensboro | KY | Food Manufacturing311223 | — | ◐ LIKELY ACTIVE |
| OSOwensboro Specialty Polymers | Owensboro | KY | Chemical Manufacturing325211 | — | ◐ LIKELY ACTIVE |
| PTPinkerton Tobacco CO. LP | Owensboro | KY | Beverage and Tobacco Product Manufacturing312229 | — | ◐ LIKELY ACTIVE |
| VLValor LLC - Valor Oil Alsop Ln | Owensboro | KY | Petroleum and Coal Products Manufacturing324199 | — | ◐ LIKELY ACTIVE |
| OGOwensboro Grain CO LLC | Owensboro | KY | Food Manufacturing311224 | — | ◐ LIKELY ACTIVE |
| CICabinotch, INC. | Owensboro | KY | Furniture and Related Product Manufacturing337110 | 20-99 | ◐ LIKELY ACTIVE |
| COCargill Owensboro Grain Company | Owensboro | KY | Food Manufacturing311222 | — | ◐ LIKELY ACTIVE |
| CMCharles Medley Distillers Ky | Owensboro | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| DLDaramic LLC | Owensboro | KY | Plastics and Rubber Products Manufacturing326113 | 20-99 | ◐ LIKELY ACTIVE |
| GRGreen River Steel CORP | Owensboro | KY | Primary Metal Manufacturing331111 | — | ◐ LIKELY ACTIVE |
| HCHinkle Contracting Company LLC - Hinkle West Paving Owensboro Asphalt Plant 0464 | Owensboro | KY | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| MSMetalsa Sa De Cv | Owensboro | KY | Transportation Equipment Manufacturing336211 | — | ◐ LIKELY ACTIVE |
| MCMeuth Construction Supply – Owensboro Plant | Owensboro | KY | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| OCOwensboro Concrete CO | Owensboro | KY | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| OROwensboro Riverport Authority - River Dock Facility | Owensboro | KY | Food Manufacturing311119 | — | ◐ LIKELY ACTIVE |
| PSPilot Steel, INC. | Owensboro | KY | Primary Metal Manufacturing331221 | — | ◐ LIKELY ACTIVE |
| TGThe Glenmore Distillery | Owensboro | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| YBYellow Banks River Terminal LLC | Owensboro | KY | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| OPOwensboro Paving CO | Owensboro | KY | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| DADE AM-RON Building Systems LLC | Owensboro | KY | Nonmetallic Mineral Product Manufacturing327390 | 20-99 | ◐ LIKELY ACTIVE |
| EEEDECO East, LLC DBA Hendrick Screen | Owensboro | KY | Fabricated Metal Product Manufacturing332999 | 20-99 | ◐ LIKELY ACTIVE |
| EPEvansville Paving LLC | Owensboro | KY | Petroleum and Coal Products Manufacturing324121 | 1-19 | ◐ LIKELY ACTIVE |
| FFactory | Owensboro | KY | Wood Product Manufacturing321911 | 100-499 | ◐ LIKELY ACTIVE |
| MSMetalsa Structural Products Inc. | Owensboro | KY | Transportation Equipment Manufacturing336211 | 100-499 | ◐ LIKELY ACTIVE |
| MAMilliken and Company - Hickory Plant (Owensboro Specialty Polymers) | Owensboro | KY | Chemical Manufacturing325199 | 20-99 | ◐ LIKELY ACTIVE |
| MMMisty Meadow Winery | Owensboro | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MOMizkan Owensboro | Owensboro | KY | Food Manufacturing311421 | 100-499 | ◐ LIKELY ACTIVE |
| MBMoonlite Bar-B-Q Inn, Inc. | Owensboro | KY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| OOwensboro | Owensboro | KY | Food Manufacturing311999 | 20-99 | ◐ LIKELY ACTIVE |
| SDSazerac Distillers, LLC d.b.a. The Glenmore Distillery | Owensboro | KY | Beverage and Tobacco Product Manufacturing312140 | 500+ | ◐ LIKELY ACTIVE |
| SMSwedish Match | Owensboro | KY | Beverage and Tobacco Product Manufacturing312230 | 500+ | ◐ LIKELY ACTIVE |
| TPTotal Packaging LLC | Owensboro | KY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| TPTotal Packaging of Kentucky, INC. | Owensboro | KY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| TTracco | Owensboro | KY | Food Manufacturing311991 | 100-499 | ◐ LIKELY ACTIVE |