 Virnig Manufacturing | Pikeville | TN | Machinery Manufacturing333111 | 20-99 | ● ACTIVE |
 American Metal Works, LLC | Pikeville | KY | Fabricated Metal Product Manufacturing332322 | — | ● ACTIVE |
 Eureka Energy Corporation | Pikeville | KY | Chemical Manufacturing325199 | — | ● ACTIVE |
| AFAviagen Feed Processing Unit | Pikeville | TN | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| ANAviagen North America, INC. | Pikeville | TN | Food Manufacturing311119 | — | ◐ LIKELY ACTIVE |
| DSDunlap Stone, INC. | Pikeville | TN | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| SPShelbiana Plant #15 | Pikeville | KY | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| BCBuffalo Creek Energy LLC - Coal to Urea Ammonia Nitrate Plant | Pikeville | KY | Petroleum and Coal Products Manufacturing324199 | — | ◇ UNVERIFIED |
| MEMountain Enterprises INC - Shelbiana Portable Plant 15 | Pikeville | KY | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| TWThe Wells Group LLC | Pikeville | KY | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| ASA Secret Garden Winery | Pikeville | NC | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BWBrothers Wright Distilling CO LLC | Pikeville | KY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CECajunChef Enterprises LLC | Pikeville | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCCrow Creek Vineyard | Pikeville | TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| JIJohnson Industries,inc | Pikeville | KY | Machinery Manufacturing333131 | 20-99 | ◐ LIKELY ACTIVE |
| KTKeesee Technologies, INC. | Pikeville | KY | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
 Wheeler Industries, INC. | Pikeville | NC | Wood Product Manufacturing321920 | — | ◇ UNVERIFIED |
| CICochran Industries INC - Ky | Pikeville | KY | Nonmetallic Mineral Product Manufacturing327331 | — | ◇ UNVERIFIED |
| CBCountry Boyz Metal LLC | Pikeville | KY | Primary Metal Manufacturing331491 | — | ◇ UNVERIFIED |
| FCFeud Country Leather, LLC | Pikeville | KY | Leather and Allied Product Manufacturing316990 | — | ◇ UNVERIFIED |
| GEGreenhill Enterprises Incorporated | Pikeville | KY | Apparel Manufacturing315990 | — | ◇ UNVERIFIED |
| MEMountain Enterprises INC | Pikeville | KY | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| MEMountain Enterprises INC - Buckleys Check Plant 28 | Pikeville | KY | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
