| SCSEK Corporation / Keay | Pittsburgh | PA | Nonmetallic Mineral Product Manufacturing327390 | 1-19 | ◐ LIKELY ACTIVE |
| SSSmallman Street | Pittsburgh | PA | Chemical Manufacturing325199 | 20-99 | ◐ LIKELY ACTIVE |
| SSSouth Shore Distilling LLC | Pittsburgh | PA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SCSpang & Company Corporate/Magnetics Division Headquarters | Pittsburgh | PA | Computer and Electronic Product Manufacturing334416 | 20-99 | ◐ LIKELY ACTIVE |
| SDSteel Dynamics Flat Roll Group - MetalTech | Pittsburgh | PA | Fabricated Metal Product Manufacturing332812 | 20-99 | ◐ LIKELY ACTIVE |
| SESt Engineering Aethon INC | Pittsburgh | PA | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| SRSweet Rust Industries | Pittsburgh | PA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| TTaktl | Pittsburgh | PA | Nonmetallic Mineral Product Manufacturing327390 | 20-99 | ◐ LIKELY ACTIVE |
| TPThar Process LLC | Pittsburgh | PA | Machinery Manufacturing333248 | — | ◐ LIKELY ACTIVE |
| TEThe Enginehouse Winery | Pittsburgh | PA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TWThrone Wellness LLC | Pittsburgh | PA | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |
| TCTslapikas Consulting LLC | Pittsburgh | PA | Computer and Electronic Product Manufacturing334516 | — | ◐ LIKELY ACTIVE |
| USUpper Saint Clair | Pittsburgh | PA | Electrical Equipment, Appliance & Component Manufacturing335210 | 20-99 | ◐ LIKELY ACTIVE |
| UVUrciuolo Vini S.a. Srl, LLC | Pittsburgh | PA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| UPUSA PA Pittsburgh Plant | Pittsburgh | PA | Chemical Manufacturing325510 | 100-499 | ◐ LIKELY ACTIVE |
| VFVelum Fermentation | Pittsburgh | PA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| VRVesuvius Research Pittsburgh - Advanced Refractories | Pittsburgh | PA | Nonmetallic Mineral Product Manufacturing327120 | 1-19 | ◐ LIKELY ACTIVE |
| WBWeiss Brothers Inc. | Pittsburgh | PA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| WPWeiss Provision Company | Pittsburgh | PA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| WCWhemco-steel Castings, INC | Pittsburgh | PA | Primary Metal Manufacturing331513 | — | ◐ LIKELY ACTIVE |
| WWWigle Whiskey | Pittsburgh | PA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| WSWilli's Ski Shop, INC North Hills | Pittsburgh | PA | Miscellaneous Manufacturing339920 | 1-19 | ◐ LIKELY ACTIVE |
| WOWine O'Clock Somewhere Winery | Pittsburgh | PA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| ZSZOLL Services - Anchor | Pittsburgh | PA | Chemical Manufacturing325412 | 100-499 | ◐ LIKELY ACTIVE |
| CICernostics INC | Pittsburgh | PA | Chemical Manufacturing325413 | — | ◐ LIKELY ACTIVE |
| TMTmp Metals Group, LTD. | Pittsburgh | PA | Primary Metal Manufacturing331410 | — | ◐ LIKELY ACTIVE |