| LPLaborie Portsmouth | Portsmouth | NH | Miscellaneous Manufacturing339112 | 100-499 | ◐ LIKELY ACTIVE |
| LLLineage Logistics, LLC | Portsmouth | VA | — | — | ◐ LIKELY ACTIVE |
| MSMain St Orchard LLC | Portsmouth | RI | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MBMoMac Brewing Company | Portsmouth | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| NPNorth Point Marine & Industrial INC | Portsmouth | NH | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| NSNorth Sails Portsmouth | Portsmouth | RI | Textile Product Mills314910 | 20-99 | ◐ LIKELY ACTIVE |
| PBPortsmouth Branch 43 | Portsmouth | VA | Chemical Manufacturing325120 | 1-19 | ◐ LIKELY ACTIVE |
| PDPortsmouth Division | Portsmouth | OH | Primary Metal Manufacturing331511 | 100-499 | ◐ LIKELY ACTIVE |
| PSPrestige Structural Repairs LLC | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| RRaytheon_Portsmouth_RI | Portsmouth | RI | Computer and Electronic Product Manufacturing334511 | 500+ | ◐ LIKELY ACTIVE |
| RLRicci Lumber | Portsmouth | NH | Wood Product Manufacturing321214 | 20-99 | ◐ LIKELY ACTIVE |
| SSSig Sauer - Aviation | Portsmouth | NH | Fabricated Metal Product Manufacturing332994 | 20-99 | ◐ LIKELY ACTIVE |
| TWTalos Welding LLC | Portsmouth | RI | Fabricated Metal Product Manufacturing332312 | — | ◐ LIKELY ACTIVE |
| TITeledyne Instruments Inc. d/b/a/ Teledyne D.G.O'Brien | Portsmouth | NH | Computer and Electronic Product Manufacturing334417 | 100-499 | ◐ LIKELY ACTIVE |
| TPThe Portsmouth Brewing Company | Portsmouth | OH | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| USUnited Shipboard Repair, INC. | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| WSW&O Supply Premier | Portsmouth | VA | Fabricated Metal Product Manufacturing332919 | 20-99 | ◐ LIKELY ACTIVE |
| JJJ J Fasteners INC | Portsmouth | VA | Miscellaneous Manufacturing339993 | — | ◐ LIKELY ACTIVE |
| KSKemsan Solutions LLC | Portsmouth | VA | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| WSWorldwide Ship Repair LLC | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |