| RSRaytheon Seapower Capability Center | Portsmouth | RI | Computer and Electronic Product Manufacturing334511 | — | ◇ UNVERIFIED |
| RARedhook Ale Brewery | Portsmouth | NH | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| SWSherwin Williams Company Portsmouth | Portsmouth | VA | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
| SCSole Choice, INC. (0773010120) | Portsmouth | OH | Textile Mills313220 | — | ◇ UNVERIFIED |
| SBSouth Bay Sand Blasting and Tank Cleaning | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◇ UNVERIFIED |
| AFArtcraft Fabricators INC | Portsmouth | VA | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| AAAtco - Aircraft Technical Company INC | Portsmouth | NH | Transportation Equipment Manufacturing336413 | — | ◐ LIKELY ACTIVE |
| BTBoston Transit Group INC | Portsmouth | NH | Transportation Equipment Manufacturing336510 | — | ◐ LIKELY ACTIVE |
| CMCollins Machine Works | Portsmouth | VA | Fabricated Metal Product Manufacturing332710 | 100-499 | ◐ LIKELY ACTIVE |
| CACopper and Oak Craft Spirits, LLC | Portsmouth | VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| ESEight Shires Brands | Portsmouth | VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GBGold Bond Building Products - Portsmouth | Portsmouth | NH | Nonmetallic Mineral Product Manufacturing327420 | 20-99 | ◐ LIKELY ACTIVE |
| HIHarbor Industrial Services INC | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| HGHartung Gallery, LLC | Portsmouth | VA | Miscellaneous Manufacturing339999 | — | ◐ LIKELY ACTIVE |
| HLHigh Liner Foods | Portsmouth | NH | Food Manufacturing311710 | 100-499 | ◐ LIKELY ACTIVE |
| HBHodges Badge Company, Inc. RI | Portsmouth | RI | Textile Product Mills314999 | 1-19 | ◐ LIKELY ACTIVE |
| HAHubbell / Aclara Meters LLC | Portsmouth | NH | Computer and Electronic Product Manufacturing334515 | 100-499 | ◐ LIKELY ACTIVE |
| IMIntercept Medical dba Laminated Films & Packaging | Portsmouth | NH | Plastics and Rubber Products Manufacturing326111 | 20-99 | ◐ LIKELY ACTIVE |
| LPLaborie Portsmouth | Portsmouth | NH | Miscellaneous Manufacturing339112 | 100-499 | ◐ LIKELY ACTIVE |
| LLLineage Logistics, LLC | Portsmouth | VA | — | — | ◐ LIKELY ACTIVE |
| MSMain St Orchard LLC | Portsmouth | RI | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MBMoMac Brewing Company | Portsmouth | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| NPNorth Point Marine & Industrial INC | Portsmouth | NH | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| NSNorth Sails Portsmouth | Portsmouth | RI | Textile Product Mills314910 | 20-99 | ◐ LIKELY ACTIVE |
| PBPortsmouth Branch 43 | Portsmouth | VA | Chemical Manufacturing325120 | 1-19 | ◐ LIKELY ACTIVE |
| PDPortsmouth Division | Portsmouth | OH | Primary Metal Manufacturing331511 | 100-499 | ◐ LIKELY ACTIVE |
| PSPrestige Structural Repairs LLC | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| RRaytheon_Portsmouth_RI | Portsmouth | RI | Computer and Electronic Product Manufacturing334511 | 500+ | ◐ LIKELY ACTIVE |
| RLRicci Lumber | Portsmouth | NH | Wood Product Manufacturing321214 | 20-99 | ◐ LIKELY ACTIVE |
| SSSig Sauer - Aviation | Portsmouth | NH | Fabricated Metal Product Manufacturing332994 | 20-99 | ◐ LIKELY ACTIVE |
| TWTalos Welding LLC | Portsmouth | RI | Fabricated Metal Product Manufacturing332312 | — | ◐ LIKELY ACTIVE |
| TITeledyne Instruments Inc. d/b/a/ Teledyne D.G.O'Brien | Portsmouth | NH | Computer and Electronic Product Manufacturing334417 | 100-499 | ◐ LIKELY ACTIVE |
| TPThe Portsmouth Brewing Company | Portsmouth | OH | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| USUnited Shipboard Repair, INC. | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| WSW&O Supply Premier | Portsmouth | VA | Fabricated Metal Product Manufacturing332919 | 20-99 | ◐ LIKELY ACTIVE |
| JJJ J Fasteners INC | Portsmouth | VA | Miscellaneous Manufacturing339993 | — | ◐ LIKELY ACTIVE |
| KSKemsan Solutions LLC | Portsmouth | VA | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| WSWorldwide Ship Repair LLC | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◐ LIKELY ACTIVE |
| CTChadwick & Trefethen INC | Portsmouth | NH | Fabricated Metal Product Manufacturing332212 | 1-19 | ◇ UNVERIFIED |
| CCCraftyOne Customs LLC | Portsmouth | RI | Miscellaneous Manufacturing339920 | 1-19 | ◇ UNVERIFIED |
| ECExquisite Custom Cabinets, Inc. | Portsmouth | VA | Furniture and Related Product Manufacturing337110 | 1-19 | ◇ UNVERIFIED |
| JSJeff Soderbergh, Inc. | Portsmouth | RI | Furniture and Related Product Manufacturing337212 | 1-19 | ◇ UNVERIFIED |
| NENew England Printing | Portsmouth | NH | Printing and Related Support Activities323114 | 1-19 | ◇ UNVERIFIED |
| SIShoreline Industries, INC. | Portsmouth | VA | Fabricated Metal Product Manufacturing332312 | 20-99 | ◇ UNVERIFIED |
| SASpirit Advisory, LLC | Portsmouth | NH | Printing and Related Support Activities323111 | 1-19 | ◇ UNVERIFIED |
| ATAaa Translogistics & Warehousing, INC. | Portsmouth | VA | Food Manufacturing311119 | — | ◇ UNVERIFIED |
| ASAbsolute Stone By Design LLC | Portsmouth | VA | Nonmetallic Mineral Product Manufacturing327991 | — | ◇ UNVERIFIED |
| ACAdvex Corporation | Portsmouth | VA | Transportation Equipment Manufacturing336611 | — | ◇ UNVERIFIED |
| AIAggregate Industries | Portsmouth | NH | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| AMAllegra Marketing Print Mail | Portsmouth | NH | Printing and Related Support Activities323111 | — | ◇ UNVERIFIED |