| VVVishay Vitramon Incorporated | Roanoke | VA | Nonmetallic Mineral Product Manufacturing327113 | — | ◇ UNVERIFIED |
| WVWelcome Valley Asphalt Plant | Roanoke | VA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| WBWestern Branch Diesel | Roanoke | VA | Machinery Manufacturing333613 | — | ◇ UNVERIFIED |
| 1P15 Peaks, LLC | Roanoke | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| 1R168 Roanoke VA | Roanoke | VA | Food Manufacturing311811 | 20-99 | ◐ LIKELY ACTIVE |
| AFA Few Old Goats Brewing | Roanoke | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| ARAmg Roa | Roanoke | VA | Fabricated Metal Product Manufacturing332710 | 1-19 | ◐ LIKELY ACTIVE |
| ASAnthro Systems Limited | Roanoke | VA | Miscellaneous Manufacturing339920 | — | ◐ LIKELY ACTIVE |
| ADAtheling Downtown | Roanoke | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| AMAtheling Meadworks | Roanoke | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BCBarrel Chest Wine And Beer | Roanoke | VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| BDBrady's Distillery | Roanoke | VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CACargill ANH - Vinton, VA | Roanoke | VA | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| CIChem-solv, INC. | Roanoke | VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CCvt-va | Roanoke | VA | Computer and Electronic Product Manufacturing334419 | 1-19 | ◐ LIKELY ACTIVE |
| DBDominion Block LLC - Roanoke | Roanoke | VA | Nonmetallic Mineral Product Manufacturing327331 | 1-19 | ◐ LIKELY ACTIVE |
| IInfoSeal | Roanoke | VA | Printing and Related Support Activities323120 | 20-99 | ◐ LIKELY ACTIVE |
| KRKoppers Roanoke | Roanoke | VA | Wood Product Manufacturing321114 | 20-99 | ◐ LIKELY ACTIVE |
| MWMarvin Windows and Doors - Roanoke | Roanoke | VA | Plastics and Rubber Products Manufacturing326199 | 500+ | ◐ LIKELY ACTIVE |
| MCMativ Conwed LLC | Roanoke | VA | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| PGPhoenix Global, LLC-Roanoke | Roanoke | VA | Primary Metal Manufacturing331110 | 1-19 | ◐ LIKELY ACTIVE |
| RBRoanoke Branch 52 | Roanoke | VA | Chemical Manufacturing325120 | 1-19 | ◐ LIKELY ACTIVE |
| RPRoanoke Plant | Roanoke | VA | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| RVRoanoke Va Bakery | Roanoke | VA | Food Manufacturing311812 | 100-499 | ◐ LIKELY ACTIVE |
| RVRoanoke VA Recycling | Roanoke | VA | Transportation Equipment Manufacturing336510 | 1-19 | ◐ LIKELY ACTIVE |
| SRSEMCO Roanoke | Roanoke | VA | Fabricated Metal Product Manufacturing332322 | 20-99 | ◐ LIKELY ACTIVE |
| SDSteel Dynamics Roanoke Bar Division | Roanoke | VA | Primary Metal Manufacturing331110 | 100-499 | ◐ LIKELY ACTIVE |
| TNThree Notchd Distilling Company | Roanoke | VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| VBVoyant Beauty Roanoke | Roanoke | VA | Chemical Manufacturing325620 | 100-499 | ◐ LIKELY ACTIVE |
| W1Wpax 1025 (roanoke, Va - F) | Roanoke | VA | Transportation Equipment Manufacturing336211 | 20-99 | ◐ LIKELY ACTIVE |
| YLY2o, LLC | Roanoke | VA | Chemical Manufacturing325180 | — | ◐ LIKELY ACTIVE |
| BRBlue Ridge Fabricators, INC. | Roanoke | VA | Fabricated Metal Product Manufacturing332312 | 1-19 | ◇ UNVERIFIED |
| BRBlue Ridge Sign & Stamp Inc | Roanoke | VA | Miscellaneous Manufacturing339950 | 1-19 | ◇ UNVERIFIED |
| HSHarkness Screens USA LTD | Roanoke | VA | Machinery Manufacturing333310 | 1-19 | ◇ UNVERIFIED |
| LLLasercam LLC | Roanoke | VA | Machinery Manufacturing333514 | 20-99 | ◇ UNVERIFIED |
| PPPress Press Merch, LLC | Roanoke | VA | Printing and Related Support Activities323113 | 1-19 | ◇ UNVERIFIED |
| TTTwist & Turns Manufacturing, INC. | Roanoke | VA | Furniture and Related Product Manufacturing337124 | 1-19 | ◇ UNVERIFIED |
| VMValley Machine CO | Roanoke | VA | Fabricated Metal Product Manufacturing332710 | 20-99 | ◇ UNVERIFIED |
| VPVirginia Plastics Company, INC. | Roanoke | VA | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| ACAdams Construction CO - Rockydale Asphalt Plant | Roanoke | VA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| ASAl Steel Fabricators | Roanoke | VA | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| ADAmerican Door and Glass Sw Va, INC. | Roanoke | VA | Fabricated Metal Product Manufacturing332321 | — | ◇ UNVERIFIED |
| AGArdagh Group | Roanoke | VA | Fabricated Metal Product Manufacturing332431 | — | ◇ UNVERIFIED |
| ACAtlas Copco Secoroc LLC | Roanoke | VA | Machinery Manufacturing333131 | — | ◇ UNVERIFIED |
| ANAzko Nobel Coatings INC. | Roanoke | VA | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
| BCBatech Corporation | Roanoke | VA | Chemical Manufacturing325991 | — | ◇ UNVERIFIED |
| BBentech | Roanoke | VA | Fabricated Metal Product Manufacturing332710 | — | ◇ UNVERIFIED |
| BBBlack Bear CORP. | Roanoke | VA | Chemical Manufacturing325611 | — | ◇ UNVERIFIED |
| BSBuck Simmons Vault Service, INC | Roanoke | VA | Nonmetallic Mineral Product Manufacturing327390 | — | ◇ UNVERIFIED |
| BSBudget Signs | Roanoke | VA | Miscellaneous Manufacturing339950 | — | ◇ UNVERIFIED |