| GCGSP Components, Inc. | Rochester | NY | Fabricated Metal Product Manufacturing332710 | 20-99 | ◐ LIKELY ACTIVE |
| HFHigh Falls Operating FIFCO USA | Rochester | NY | Beverage and Tobacco Product Manufacturing312120 | 500+ | ◐ LIKELY ACTIVE |
| HBHomeTown Brew | Rochester | NY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| IAIkoniq Airline | Rochester | NY | Fabricated Metal Product Manufacturing332311 | 20-99 | ◐ LIKELY ACTIVE |
Immediate Mailing Services, Inc. | Rochester | NY | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| IPIngredients PLUS: HQ | Rochester | NY | Food Manufacturing311999 | 1-19 | ◐ LIKELY ACTIVE |
Innovation Semiconductor INC. | Rochester | NY | Computer and Electronic Product Manufacturing334413 | — | ◐ LIKELY ACTIVE |
| ITIron Tug Brewing | Rochester | NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| JFJK Findings | Rochester | NY | Miscellaneous Manufacturing339910 | 20-99 | ◐ LIKELY ACTIVE |
| JKJ. Kozel & Son, Inc. dba Kozel Steel | Rochester | NY | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| KAKodak Alaris Rochester NY | Rochester | NY | Machinery Manufacturing333316 | 100-499 | ◐ LIKELY ACTIVE |
| LDLazer D LLC | Rochester | NY | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| LLLiDestri Lee Road South | Rochester | NY | Food Manufacturing311421 | 100-499 | ◐ LIKELY ACTIVE |
| LELightning Emc LLC | Rochester | NY | Computer and Electronic Product Manufacturing334515 | — | ◐ LIKELY ACTIVE |
| MPMarket Place | Rochester | NY | Miscellaneous Manufacturing339114 | 20-99 | ◐ LIKELY ACTIVE |
| MMassari | Rochester | NY | Computer and Electronic Product Manufacturing334220 | 100-499 | ◐ LIKELY ACTIVE |
| MDMastodon Design LLC | Rochester | NY | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| MIMcAlpin Industries Hollenbeck | Rochester | NY | Fabricated Metal Product Manufacturing332322 | 100-499 | ◐ LIKELY ACTIVE |
| MSMerikan Stronghold Meadery | Rochester | NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MRMKS Rochester Highpower | Rochester | NY | Electrical Equipment, Appliance & Component Manufacturing335999 | 100-499 | ◐ LIKELY ACTIVE |
| MCMulti-Color Corporation - Rochester | Rochester | NY | Printing and Related Support Activities323111 | 100-499 | ◐ LIKELY ACTIVE |
| NSNathan's Soup & Salad | Rochester | NY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| NINordon Inc | Rochester | NY | Plastics and Rubber Products Manufacturing326199 | 100-499 | ◐ LIKELY ACTIVE |
| NANorth America Region Rochester | Rochester | NY | Machinery Manufacturing333242 | 20-99 | ◐ LIKELY ACTIVE |
| NRNy76 Rochester Instruments | Rochester | NY | Computer and Electronic Product Manufacturing334513 | 20-99 | ◐ LIKELY ACTIVE |
| NRNY, Rochester - Innovation Dr RTP 5-6 (SAS-SS) | Rochester | NY | Computer and Electronic Product Manufacturing334511 | 100-499 | ◐ LIKELY ACTIVE |
Orafol Americas OPTS | Rochester | NY | Fabricated Metal Product Manufacturing332813 | 20-99 | ◐ LIKELY ACTIVE |
| PSPallet Services Inc- Rochester | Rochester | NY | Wood Product Manufacturing321920 | 20-99 | ◐ LIKELY ACTIVE |
| PFPalmer Food Service | Rochester | NY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| PLPaneffort LLC | Rochester | NY | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| PIPennant Ingredients Buffalo Rd Location | Rochester | NY | Food Manufacturing311812 | 20-99 | ◐ LIKELY ACTIVE |
| PIPennant Ingredients Chester Location | Rochester | NY | Food Manufacturing311812 | 20-99 | ◐ LIKELY ACTIVE |
| PGPhoenix Graphics, Inc. | Rochester | NY | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| P1Plant 1 | Rochester | NY | Machinery Manufacturing333415 | 20-99 | ◐ LIKELY ACTIVE |
| PEPolymer Engineered Products, Inc | Rochester | NY | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| PEPrimalyn Enterprises DBA Jason Manufacturing | Rochester | NY | Furniture and Related Product Manufacturing337211 | 20-99 | ◐ LIKELY ACTIVE |
| QRQuidelOrtho Rochester 642 | Rochester | NY | Chemical Manufacturing325413 | 100-499 | ◐ LIKELY ACTIVE |
| QRQuidelOrtho Rochester CNP100 | Rochester | NY | Chemical Manufacturing325413 | 100-499 | ◐ LIKELY ACTIVE |
| QRQuidelOrtho Rochester CNP 130 | Rochester | NY | Chemical Manufacturing325413 | 100-499 | ◐ LIKELY ACTIVE |
| RFR&D Facility | Rochester | NY | Machinery Manufacturing333924 | 20-99 | ◐ LIKELY ACTIVE |
| RRochester | Rochester | NY | Fabricated Metal Product Manufacturing332618 | 500+ | ◐ LIKELY ACTIVE |
| RNRochester, NY (Mastodon) (Q14) | Rochester | NY | Computer and Electronic Product Manufacturing334220 | 100-499 | ◐ LIKELY ACTIVE |
| RRRochester Ready Mix | Rochester | NY | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| RSRochester Structural LLC | Rochester | NY | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| RGRonald Garrow | Rochester | NY | Computer and Electronic Product Manufacturing334220 | — | ◐ LIKELY ACTIVE |
| RNRosenkrans Natural Beef Company, LLC | Rochester | NY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| SASeed and Stone Cidery | Rochester | NY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SESimcona Electronics Corp MC | Rochester | NY | Electrical Equipment, Appliance & Component Manufacturing335314 | 20-99 | ◐ LIKELY ACTIVE |
| SDSir Delicious | Rochester | NY | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| SSSolid Surfaces NY Rochester | Rochester | NY | Nonmetallic Mineral Product Manufacturing327991 | 20-99 | ◐ LIKELY ACTIVE |