| LILemar Industries | Sheffield | IA | Machinery Manufacturing333111 | — | ◇ UNVERIFIED |
| BMBerkshire Mountain Distillers | Sheffield | MA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FMFord Motor Company (former Sacp) | Sheffield | AL | Transportation Equipment Manufacturing336110 | — | ◐ LIKELY ACTIVE |
| PSPlaskolite Sheffield, LLC | Sheffield | MA | Plastics and Rubber Products Manufacturing326113 | 20-99 | ◐ LIKELY ACTIVE |
| SCSheffield Container Corporation | Sheffield | PA | Wood Product Manufacturing321920 | 20-99 | ◐ LIKELY ACTIVE |
| SPSheffield Plastics | Sheffield | MA | Plastics and Rubber Products Manufacturing326113 | — | ◐ LIKELY ACTIVE |
| SMSukup Manufacturing CO | Sheffield | IA | Machinery Manufacturing333111 | — | ◐ LIKELY ACTIVE |
| ECEuclid Chemical Fire | Sheffield | IL | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
| GLGreat Lakes an Oldcastle Company | Sheffield | OH | Nonmetallic Mineral Product Manufacturing327331 | — | ◇ UNVERIFIED |
| LCLane Construction CORP | Sheffield | MA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| LOLumber One Wood Preserving LLC | Sheffield | AL | Wood Product Manufacturing321114 | — | ◇ UNVERIFIED |
| TCThree Creek Bioenergy | Sheffield | OH | Chemical Manufacturing325199 | — | ◇ UNVERIFIED |
| WAWise Alloys LLC Sheffield Ops | Sheffield | AL | Primary Metal Manufacturing331315 | — | ◇ UNVERIFIED |
| ACAllegheny Cellars Winery | Sheffield | PA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| DLDeuxcox LLC | Sheffield | AL | Textile Mills313310 | — | ◐ LIKELY ACTIVE |
| LILeMar Industries-SHE | Sheffield | IA | Fabricated Metal Product Manufacturing332999 | 20-99 | ◐ LIKELY ACTIVE |
| RGRockview Group, INC. | Sheffield | AL | Machinery Manufacturing333517 | — | ◐ LIKELY ACTIVE |
| SSSukup Sheffield Manufacturing Facility | Sheffield | IA | Machinery Manufacturing333111 | 500+ | ◐ LIKELY ACTIVE |
| SMSunset Meadow | Sheffield | MA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| 3L3-d, LLC | Sheffield | AL | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| BMBerkshire Mountain Distillers, Inc. | Sheffield | MA | Beverage and Tobacco Product Manufacturing312140 | — | ◇ UNVERIFIED |
| DBDon Brown Printing, Company | Sheffield | AL | Printing and Related Support Activities323111 | — | ◇ UNVERIFIED |
| RVRiver Valley Cooperative | Sheffield | IL | Miscellaneous Manufacturing339999 | — | ◇ UNVERIFIED |