| ASAlbea Shelbyville | Shelbyville | TN | Plastics and Rubber Products Manufacturing326112 | 100-499 | ◐ LIKELY ACTIVE |
| AFAmcor Flexibles | Shelbyville | KY | Plastics and Rubber Products Manufacturing326112 | 100-499 | ◐ LIKELY ACTIVE |
| AFAmcor Flexibles, Liquids | Shelbyville | KY | Plastics and Rubber Products Manufacturing326112 | 100-499 | ◐ LIKELY ACTIVE |
| AGAmerican Graphene Partners LTD. | Shelbyville | IL | Electrical Equipment, Appliance & Component Manufacturing335991 | — | ◐ LIKELY ACTIVE |
| CWCharlemagne Winery LP | Shelbyville | TN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CFChristianburg Farms | Shelbyville | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CSCooper Steel | Shelbyville | TN | Fabricated Metal Product Manufacturing332311 | 500+ | ◐ LIKELY ACTIVE |
| DKDoor Knocker Whiskey | Shelbyville | KY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| HHHappy Hill Wine Company | Shelbyville | IL | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| IBIron Bridge Winery | Shelbyville | IN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| JCJeptha Creed Distillery | Shelbyville | KY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| KSKi Shelbyville Truss | Shelbyville | KY | Wood Product Manufacturing321215 | 20-99 | ◐ LIKELY ACTIVE |
| KIKnauf Insulation Plant 3 | Shelbyville | IN | Nonmetallic Mineral Product Manufacturing327993 | 100-499 | ◐ LIKELY ACTIVE |
| MSMetal Solutions - Indianapolis | Shelbyville | IN | Fabricated Metal Product Manufacturing332311 | 20-99 | ◐ LIKELY ACTIVE |
| NGNearest Green Distillery, INC. | Shelbyville | TN | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| NANifco America Corporation KY | Shelbyville | KY | Plastics and Rubber Products Manufacturing326199 | 100-499 | ◐ LIKELY ACTIVE |
| PUPK U.S.A. Inc | Shelbyville | IN | Transportation Equipment Manufacturing336370 | 100-499 | ◐ LIKELY ACTIVE |
| SPShelbyville Packaging Operations Center | Shelbyville | TN | Miscellaneous Manufacturing339940 | 100-499 | ◐ LIKELY ACTIVE |
| TWTalon Winery | Shelbyville | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TCTaylor Comms - Shelbyville IN - 0116-INSH1 | Shelbyville | IN | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| TBThe Blending House | Shelbyville | KY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| TMThe Maven Distillery | Shelbyville | KY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| TSTriumph - Shelbyville, IN | Shelbyville | IN | Transportation Equipment Manufacturing336413 | 20-99 | ◐ LIKELY ACTIVE |
| VRvoestalpine Roll Forming Corporation Aerospace Division | Shelbyville | KY | Fabricated Metal Product Manufacturing332114 | 20-99 | ◐ LIKELY ACTIVE |
| VRvoestalpine Roll Forming Corporation Commercial Division | Shelbyville | KY | Fabricated Metal Product Manufacturing332114 | 100-499 | ◐ LIKELY ACTIVE |