| RDRyobi Die Casting (usa), INC. | Shelbyville | IN | Primary Metal Manufacturing331521 | 500+ | ◐ LIKELY ACTIVE |
| NFNucor Fastener Shelbyville | Shelbyville | IN | Primary Metal Manufacturing331222 | 20-99 | ◐ LIKELY ACTIVE |
| DCDubois Chemicals - American Finishing Resources | Shelbyville | IN | Fabricated Metal Product Manufacturing332813 | — | ◐ LIKELY ACTIVE |
| KIKnauf Insulation Incorporated | Shelbyville | IN | Nonmetallic Mineral Product Manufacturing327993 | — | ◐ LIKELY ACTIVE |
| PNPilkington North America Incorporated | Shelbyville | IN | Nonmetallic Mineral Product Manufacturing327211 | 100-499 | ◐ LIKELY ACTIVE |
| TRToray Resin Company TREC | Shelbyville | IN | Chemical Manufacturing325991 | 20-99 | ◐ LIKELY ACTIVE |
| WLWap LLC | Shelbyville | IN | Fabricated Metal Product Manufacturing332999 | 20-99 | ◐ LIKELY ACTIVE |
| OHOld Hickory Furniture Company | Shelbyville | IN | Furniture and Related Product Manufacturing337121 | — | ◐ LIKELY ACTIVE |
| YMYushiro Manufacturing America | Shelbyville | IN | Petroleum and Coal Products Manufacturing324191 | — | ◐ LIKELY ACTIVE |
| BMBanks Machine & Engineering, LLC | Shelbyville | IN | Machinery Manufacturing333248 | — | ◐ LIKELY ACTIVE |
| IIpf | Shelbyville | IN | Transportation Equipment Manufacturing336390 | 20-99 | ◐ LIKELY ACTIVE |
| IBIron Bridge Winery | Shelbyville | IN | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| KIKnauf Insulation Plant 3 | Shelbyville | IN | Nonmetallic Mineral Product Manufacturing327993 | 100-499 | ◐ LIKELY ACTIVE |
| MSMetal Solutions - Indianapolis | Shelbyville | IN | Fabricated Metal Product Manufacturing332311 | 20-99 | ◐ LIKELY ACTIVE |
| PUPK U.S.A. Inc | Shelbyville | IN | Transportation Equipment Manufacturing336370 | 100-499 | ◐ LIKELY ACTIVE |
| TCTaylor Comms - Shelbyville IN - 0116-INSH1 | Shelbyville | IN | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| TSTriumph - Shelbyville, IN | Shelbyville | IN | Transportation Equipment Manufacturing336413 | 20-99 | ◐ LIKELY ACTIVE |