| H2Helper 24, LTD | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326111 | — | ◐ LIKELY ACTIVE |
| KPKamps Pallets - Sioux Falls | Sioux Falls | SD | Wood Product Manufacturing321920 | 1-19 | ◐ LIKELY ACTIVE |
| KGKlogo Group, INC | Sioux Falls | SD | Apparel Manufacturing315990 | — | ◐ LIKELY ACTIVE |
| LSLubricants Sioux Falls | Sioux Falls | SD | Petroleum and Coal Products Manufacturing324191 | 1-19 | ◐ LIKELY ACTIVE |
| MTMaguire Tank | Sioux Falls | SD | Fabricated Metal Product Manufacturing332420 | 100-499 | ◐ LIKELY ACTIVE |
| NLNevr Looz LLC | Sioux Falls | SD | Miscellaneous Manufacturing339920 | — | ◐ LIKELY ACTIVE |
| NSNorcraft - Sioux Falls | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 100-499 | ◐ LIKELY ACTIVE |
| OFOrion Food Systems | Sioux Falls | SD | — | — | ◐ LIKELY ACTIVE |
| OFOrion Food Systems, LLC | Sioux Falls | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| PMPanacea Meadery | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| PMPFG Manufacturing OLM Food Systems Sioux Falls - 4040 | Sioux Falls | SD | Machinery Manufacturing333241 | 100-499 | ◐ LIKELY ACTIVE |
| PMP & M Steel | Sioux Falls | SD | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| PDProSmiles Dental Studio Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339116 | 1-19 | ◐ LIKELY ACTIVE |
| PRProsperous Robotics Group, INC. | Sioux Falls | SD | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| RHRaven HQ | Sioux Falls | SD | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| RMRaven Manufacturing | Sioux Falls | SD | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| RDRegional Dental Lab, LLC | Sioux Falls | SD | Miscellaneous Manufacturing339116 | — | ◐ LIKELY ACTIVE |
| SDSd02-dakt-south Dakota Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339950 | 100-499 | ◐ LIKELY ACTIVE |
| SLSenproco, LLC | Sioux Falls | SD | Chemical Manufacturing325611 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Admin Office | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Kitchen & Bath | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 100-499 | ◐ LIKELY ACTIVE |
| SFSioux Falls Location | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Regional Bakery - Main Store | Sioux Falls | SD | Food Manufacturing311812 | 20-99 | ◐ LIKELY ACTIVE |
| SFSmithfield Foods | Sioux Falls | SD | Food Manufacturing311611 | 500+ | ◐ LIKELY ACTIVE |
| SCSweetman Construction Company d/b/a Concrete Materials | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | 100-499 | ◐ LIKELY ACTIVE |
| TDTriple D Marketing, INC | Sioux Falls | SD | Chemical Manufacturing325612 | — | ◐ LIKELY ACTIVE |
| WTWheeler Tank Manufacturing, Inc. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332420 | 20-99 | ◐ LIKELY ACTIVE |
| WCWin Chill Cold Storage, LLC | Sioux Falls | SD | — | — | ◐ LIKELY ACTIVE |