| FDFernson Distilling Co. | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FGFive Glass Winery & Vineyard | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FIFlagshooter, Inc | Sioux Falls | SD | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
| GDG&H Distributing | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326220 | 20-99 | ◐ LIKELY ACTIVE |
| GLGlacial Lakes Distillery and Brewhouse LLC | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GNGlanbia Nutritionals (NA) Inc. - Sioux Falls | Sioux Falls | SD | Food Manufacturing311211 | 20-99 | ◐ LIKELY ACTIVE |
| GPGrand Prairie Foods, Inc. | Sioux Falls | SD | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |
| H2Helper 24, LTD | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326111 | — | ◐ LIKELY ACTIVE |
| KPKamps Pallets - Sioux Falls | Sioux Falls | TX | Wood Product Manufacturing321920 | 1-19 | ◐ LIKELY ACTIVE |
| KPKamps Pallets - Sioux Falls | Sioux Falls | SD | Wood Product Manufacturing321920 | 1-19 | ◐ LIKELY ACTIVE |
| KGKlogo Group, INC | Sioux Falls | SD | Apparel Manufacturing315990 | — | ◐ LIKELY ACTIVE |
| LSLubricants Sioux Falls | Sioux Falls | SD | Petroleum and Coal Products Manufacturing324191 | 1-19 | ◐ LIKELY ACTIVE |
| MTMaguire Tank | Sioux Falls | SD | Fabricated Metal Product Manufacturing332420 | 100-499 | ◐ LIKELY ACTIVE |
| NLNevr Looz LLC | Sioux Falls | SD | Miscellaneous Manufacturing339920 | — | ◐ LIKELY ACTIVE |
| NSNorcraft - Sioux Falls | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 100-499 | ◐ LIKELY ACTIVE |
| OFOrion Food Systems, LLC | Sioux Falls | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| PMPanacea Meadery | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| PMPFG Manufacturing OLM Food Systems Sioux Falls - 4040 | Sioux Falls | SD | Machinery Manufacturing333241 | 100-499 | ◐ LIKELY ACTIVE |
| PDProSmiles Dental Studio Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339116 | 1-19 | ◐ LIKELY ACTIVE |
| PRProsperous Robotics Group, INC. | Sioux Falls | SD | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| RHRaven HQ | Sioux Falls | SD | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| RMRaven Manufacturing | Sioux Falls | SD | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| SDSd02-dakt-south Dakota Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339950 | 100-499 | ◐ LIKELY ACTIVE |
| SFSioux Falls Admin Office | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Kitchen & Bath | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 100-499 | ◐ LIKELY ACTIVE |
| SFSioux Falls Location | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Regional Bakery - Main Store | Sioux Falls | SD | Food Manufacturing311812 | 20-99 | ◐ LIKELY ACTIVE |
| SFSmithfield Foods | Sioux Falls | SD | Food Manufacturing311611 | 500+ | ◐ LIKELY ACTIVE |
| SCSweetman Construction Company d/b/a Concrete Materials | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | 100-499 | ◐ LIKELY ACTIVE |
| TDTriple D Marketing, INC | Sioux Falls | SD | Chemical Manufacturing325612 | — | ◐ LIKELY ACTIVE |
| WTWheeler Tank Manufacturing, Inc. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332420 | 20-99 | ◐ LIKELY ACTIVE |
| WCWin Chill Cold Storage, LLC | Sioux Falls | SD | — | — | ◐ LIKELY ACTIVE |
| AJA-1 Jet, L.L.C. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332710 | 1-19 | ◇ UNVERIFIED |
| AGAVPRO Global Holdings LLC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334419 | 20-99 | ◇ UNVERIFIED |
| BCBullseye Custom Cabinetry, Inc. | Sioux falls | SD | Furniture and Related Product Manufacturing337122 | 20-99 | ◇ UNVERIFIED |
| CMCreative Metal Solutions, Inc. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332312 | 1-19 | ◇ UNVERIFIED |
| CPCtrl P, LLC | Sioux Falls | SD | Printing and Related Support Activities323111 | 1-19 | ◇ UNVERIFIED |
| DSDakota Splash, INC. | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312112 | 1-19 | ◇ UNVERIFIED |
| EBEdwin Besestre | Sioux Falls | SD | Food Manufacturing311813 | 1-19 | ◇ UNVERIFIED |
| HPHigh Performance Engineering Inc. | Sioux Falls | SD | Machinery Manufacturing333511 | 1-19 | ◇ UNVERIFIED |
| LJL J Industries INC | Sioux Falls | SD | Machinery Manufacturing333992 | 1-19 | ◇ UNVERIFIED |
| MPMueller Pallets LLC | Sioux Falls | SD | Wood Product Manufacturing321920 | 20-99 | ◇ UNVERIFIED |
| ASAltered Species Ales LLC | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| AIAmerican Ink Properties, LLC | Sioux Falls | SD | Printing and Related Support Activities323113 | — | ◇ UNVERIFIED |
| BUBaking Up a Storm LLC | Sioux Falls | SD | Food Manufacturing311811 | — | ◇ UNVERIFIED |
| BMB&B Molding Inc | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| BSBruce Sign Company | Sioux Falls | SD | Miscellaneous Manufacturing339950 | — | ◇ UNVERIFIED |
| CMComponent Manufacturing Company | Sioux Falls | SD | Wood Product Manufacturing321992 | — | ◇ UNVERIFIED |
| CMConcrete Materials Portable | Sioux Falls | NE | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| GFG3 Fire, LLC | Sioux Falls | SD | Miscellaneous Manufacturing339999 | — | ◇ UNVERIFIED |