| GIGraco INC - Sioux Falls Facility | Sioux Falls | SD | Machinery Manufacturing333914 | 100-499 | ◐ LIKELY ACTIVE |
| SPSmithfield Packaged Meats CORP. - Sioux Falls, Sd | Sioux Falls | SD | Food Manufacturing311412 | — | ◐ LIKELY ACTIVE |
| CSCreative Surfaces INC | Sioux Falls | SD | Furniture and Related Product Manufacturing337212 | 100-499 | ◐ LIKELY ACTIVE |
| DKDakota Kitchen & Bath INC. | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 20-99 | ◐ LIKELY ACTIVE |
| ESEgger Steel Company | Sioux Falls | SD | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| MAMyrl and Roy's Paving, INC. | Sioux Falls | SD | Petroleum and Coal Products Manufacturing324121 | 20-99 | ◐ LIKELY ACTIVE |
| SCStarmark Cabinetry | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | — | ◐ LIKELY ACTIVE |
| PSPreform Solutions, INC. | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
| ARAce Ready Mix- Sioux Falls | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| CLCcl Label Modern Press Div | Sioux Falls | SD | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| ETEngineered Truss Systems, INC. | Sioux Falls | SD | Wood Product Manufacturing321214 | 20-99 | ◐ LIKELY ACTIVE |
| GBGage Bros. Concrete Products INC. | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327390 | — | ◐ LIKELY ACTIVE |
| PBPremier Bee LLC | Sioux Falls | SD | Wood Product Manufacturing321999 | 20-99 | ◐ LIKELY ACTIVE |
| PCPresidio Components INC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| SIScherer Inc. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332710 | 20-99 | ◐ LIKELY ACTIVE |
| LEL.g. Everist, INC. - East Sioux Quarry | Sioux Falls | SD | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| LELumber Exchange, LLC C/o Lloyd Companies | Sioux Falls | SD | Computer and Electronic Product Manufacturing334512 | — | ◐ LIKELY ACTIVE |
| MWMaguire Water | Sioux Falls | SD | Fabricated Metal Product Manufacturing332420 | — | ◐ LIKELY ACTIVE |
| PCPresidio Components, INC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| AMAbilene Machine, LLC Sioux Falls | Sioux Falls | SD | Machinery Manufacturing333111 | 1-19 | ◐ LIKELY ACTIVE |
| ANAgriCare Nutrition | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| AFAmc Flatwater Federal Solutions Jv LLC | Sioux Falls | SD | Furniture and Related Product Manufacturing337127 | — | ◐ LIKELY ACTIVE |
| AFAmesburyTruth-Sioux Falls | Sioux Falls | SD | Fabricated Metal Product Manufacturing332321 | 100-499 | ◐ LIKELY ACTIVE |
| BSBCI - Sioux Falls Division | Sioux Falls | SD | Paper Manufacturing322211 | 20-99 | ◐ LIKELY ACTIVE |
| BGBerry Global LLC | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326111 | 100-499 | ◐ LIKELY ACTIVE |
| BFBlackFork Farms | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| B4Branch 418 | Sioux Falls | SD | Miscellaneous Manufacturing339115 | 1-19 | ◐ LIKELY ACTIVE |
| BABreadsmith-Duluth ave | Sioux Falls | SD | Food Manufacturing311811 | 1-19 | ◐ LIKELY ACTIVE |
| BEBreadsmith East | Sioux Falls | SD | Food Manufacturing311811 | 1-19 | ◐ LIKELY ACTIVE |
| BSBreadsmith South | Sioux Falls | SD | Food Manufacturing311811 | 1-19 | ◐ LIKELY ACTIVE |
| BWBreadsmith West | Sioux Falls | SD | Food Manufacturing311811 | 1-19 | ◐ LIKELY ACTIVE |
| BPBuilding Products Inc. of SD (Millwork) | Sioux Falls | SD | Wood Product Manufacturing321911 | 20-99 | ◐ LIKELY ACTIVE |
| CHCCL Healthcare | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| CLCCL Label SF1 | Sioux Falls | SD | Printing and Related Support Activities323111 | 100-499 | ◐ LIKELY ACTIVE |
| CPCorrugated Packaging Sioux Falls CT | Sioux Falls | SD | Paper Manufacturing322211 | 100-499 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power OEM | Sioux Falls | SD | Fabricated Metal Product Manufacturing332912 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power SF | Sioux Falls | SD | Fabricated Metal Product Manufacturing332912 | 20-99 | ◐ LIKELY ACTIVE |
| DMDakotaland Manufacturing | Sioux Falls | SD | Fabricated Metal Product Manufacturing332216 | 100-499 | ◐ LIKELY ACTIVE |
| ESEast Side Jersey Dairy - Sioux Falls Operations | Sioux Falls | SD | Food Manufacturing311511 | 20-99 | ◐ LIKELY ACTIVE |
| FSFCP Sioux Falls | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| FEFermentation Experts USA LLC | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| FDFernson Distilling Co. | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FDFernson Distilling Co. | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FGFive Glass Winery & Vineyard | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FIFlagshooter, Inc | Sioux Falls | SD | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
| GDG&H Distributing | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326220 | 20-99 | ◐ LIKELY ACTIVE |
| GLGlacial Lakes Distillery and Brewhouse LLC | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GNGlanbia Nutritionals (NA) Inc. - Sioux Falls | Sioux Falls | SD | Food Manufacturing311211 | 20-99 | ◐ LIKELY ACTIVE |
| GPGrand Prairie Foods, Inc. | Sioux Falls | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| GPGrand Prairie Foods, Inc. | Sioux Falls | SD | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |