David Saunders INC | South Portland | ME | Computer and Electronic Product Manufacturing334418 | — | ● ACTIVE |
| DUDiodes US Manufacturing Incorporated | South Portland | ME | Computer and Electronic Product Manufacturing334413 | — | ◐ LIKELY ACTIVE |
| TITexas Instruments Manufacturing Facility | South Portland | ME | Machinery Manufacturing333242 | — | ◇ UNVERIFIED |
| DPDurastone Precast Incorporated-south Portland | South Portland | ME | Nonmetallic Mineral Product Manufacturing327331 | — | ◐ LIKELY ACTIVE |
| MJMegquire & Jones CORP | South Portland | ME | Fabricated Metal Product Manufacturing332312 | — | ◐ LIKELY ACTIVE |
| GLGrow-tech LLC | South Portland | ME | Plastics and Rubber Products Manufacturing326150 | — | ◇ UNVERIFIED |
| SPSouth Port Marine | South Portland | ME | Transportation Equipment Manufacturing336611 | — | ◇ UNVERIFIED |
| UCU.s. Coast Guard South Portland Base | South Portland | ME | Transportation Equipment Manufacturing336611 | — | ◇ UNVERIFIED |
| ASAmerican Steel and Aluminum LLC | South Portland | ME | Fabricated Metal Product Manufacturing332312 | — | ▲ REPORTED CLOSED |
| BCBay Cider Works | South Portland | ME | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FRFore River Brewing Company LLC | South Portland | ME | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| HCHews Company, LLC | South Portland | ME | Transportation Equipment Manufacturing336211 | — | ◐ LIKELY ACTIVE |
| NDNational Distributors INC. | South Portland | ME | Beverage and Tobacco Product Manufacturing312111 | — | ◐ LIKELY ACTIVE |
| SPSouth Portland (2) | South Portland | ME | Computer and Electronic Product Manufacturing334413 | 100-499 | ◐ LIKELY ACTIVE |
| CWCape Whoopie, Maine's Gourmet Whoopie Pie | South Portland | ME | Food Manufacturing311812 | — | ◇ UNVERIFIED |
| CBCasco Bay Steel Structures, INC. | South Portland | ME | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| CBConnors Brunswick, INC. | South Portland | ME | Food Manufacturing311712 | — | ◇ UNVERIFIED |
| GWGraphik Wear Inc. | South Portland | ME | Printing and Related Support Activities323113 | — | ◇ UNVERIFIED |
| GBGriffin Bakery LLC | South Portland | ME | Food Manufacturing311811 | — | ◇ UNVERIFIED |
| IFInland Fresh Seafood Corporation of America, INC. | South Portland | ME | Food Manufacturing311710 | — | ◇ UNVERIFIED |
| IDIsland Dog Brewing | South Portland | ME | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| NENew England Inspection, INC. | South Portland | ME | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| NMNight Moves, LLC | South Portland | ME | Food Manufacturing311811 | — | ◇ UNVERIFIED |
| PSPortland Shellfish Company, INC. | South Portland | ME | Food Manufacturing311712 | — | ◇ UNVERIFIED |
| SSSopo Sofa And Upholstery LLC | South Portland | ME | Furniture and Related Product Manufacturing337121 | — | ◇ UNVERIFIED |
| TSThe Send Properties, LLC | South Portland | ME | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |