| L1Lci 145 | Springfield | MO | Furniture and Related Product Manufacturing337121 | 100-499 | ◐ LIKELY ACTIVE |
| LWLeffel Works | Springfield | OH | Transportation Equipment Manufacturing336370 | 100-499 | ◐ LIKELY ACTIVE |
| MAMartinrea Automotive Structures (U.S.A.), Inc. Springfield Division | Springfield | TN | Transportation Equipment Manufacturing336370 | 100-499 | ◐ LIKELY ACTIVE |
| MCMckenzie Crest Wines LLC | Springfield | OR | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MSMCT Springfield Components | Springfield | MO | Wood Product Manufacturing321215 | 1-19 | ◐ LIKELY ACTIVE |
| MGMidland Garage Door - Springfield | Springfield | NE | Fabricated Metal Product Manufacturing332321 | 20-99 | ◐ LIKELY ACTIVE |
| MNMissouri Neon | Springfield | MO | Miscellaneous Manufacturing339950 | 20-99 | ◐ LIKELY ACTIVE |
| NRNorthern Region Springfield | Springfield | OR | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| NRNorthern Region Springfield RD Lab | Springfield | OR | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| NFNothum Food Processing Systems | Springfield | MO | Machinery Manufacturing333241 | 100-499 | ◐ LIKELY ACTIVE |
| OKO.S. Kelly Company | Springfield | OH | Primary Metal Manufacturing331511 | 20-99 | ◐ LIKELY ACTIVE |
| ODOttawa Dental Laboratory, LLC - Springfield Location | Springfield | IL | Miscellaneous Manufacturing339116 | 20-99 | ◐ LIKELY ACTIVE |
| PMPalmer Manufacturing & Supply, Inc. | Springfield | OH | Machinery Manufacturing333249 | 20-99 | ◐ LIKELY ACTIVE |
| PEPositronic Eldon Facility | Springfield | MO | Computer and Electronic Product Manufacturing334417 | 100-499 | ◐ LIKELY ACTIVE |
| PJPotter Jane Distilling Company | Springfield | KY | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| PCPratt (Jett Corr), Inc. | Springfield | OH | Paper Manufacturing322211 | 100-499 | ◐ LIKELY ACTIVE |
| PMPrecision Metal-tech, LLC | Springfield | MO | Fabricated Metal Product Manufacturing332312 | — | ◐ LIKELY ACTIVE |
| PSPrestressed - Springfield | Springfield | MO | Nonmetallic Mineral Product Manufacturing327390 | 20-99 | ◐ LIKELY ACTIVE |
| PSPropak - Springfield, MO | Springfield | MO | Wood Product Manufacturing321920 | 20-99 | ◐ LIKELY ACTIVE |
| PSPurity - Springfield | Springfield | MI | Machinery Manufacturing333992 | 1-19 | ◐ LIKELY ACTIVE |
| RCRing Container Springfield | Springfield | NJ | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
| RMRM Materials Handling | Springfield | OH | Machinery Manufacturing333923 | 20-99 | ◐ LIKELY ACTIVE |
| RHRolling Hills Vineyard, LLC | Springfield | KY | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RLRoshel LLC | Springfield | OH | Transportation Equipment Manufacturing336992 | — | ◐ LIKELY ACTIVE |
| RRRost Ready Mix Springfield | Springfield | MO | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| SCSEK Corporation / Beam | Springfield | OH | Nonmetallic Mineral Product Manufacturing327390 | 1-19 | ◐ LIKELY ACTIVE |
| SBSelect Brands L.L.C. | Springfield | MO | — | — | ◐ LIKELY ACTIVE |
| SMSGFB - Midwest Block | Springfield | MO | Nonmetallic Mineral Product Manufacturing327331 | 20-99 | ◐ LIKELY ACTIVE |
| SISilfex Inc. Springfield | Springfield | OH | Computer and Electronic Product Manufacturing334413 | 100-499 | ◐ LIKELY ACTIVE |
| SGSLM Gyro & Donor, LLC | Springfield | NJ | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| SESnyder Equipment Springfield | Springfield | MO | Transportation Equipment Manufacturing336510 | 100-499 | ◐ LIKELY ACTIVE |
| SSSoltech, Sprinfield TN | Springfield | TN | Nonmetallic Mineral Product Manufacturing327993 | 20-99 | ◐ LIKELY ACTIVE |
| SCSPIPP Contech Engineered Solutions LLC | Springfield | IL | Plastics and Rubber Products Manufacturing326122 | 20-99 | ◐ LIKELY ACTIVE |
| SSpringfield | Springfield | OH | Wood Product Manufacturing321999 | 20-99 | ◐ LIKELY ACTIVE |
| SSpringfield | Springfield | IL | Nonmetallic Mineral Product Manufacturing327332 | 20-99 | ◐ LIKELY ACTIVE |
| SSpringfield | Springfield | MA | Food Manufacturing311911 | 20-99 | ◐ LIKELY ACTIVE |
| SASpringfield Assembly Plant | Springfield | OH | Transportation Equipment Manufacturing336112 | 500+ | ◐ LIKELY ACTIVE |
| SBSpringfield Branch 07 | Springfield | VA | Chemical Manufacturing325120 | 1-19 | ◐ LIKELY ACTIVE |
| SBSpringfield Brewing Company | Springfield | MO | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SFSpringfield Factory KHA | Springfield | OH | Machinery Manufacturing333923 | 100-499 | ◐ LIKELY ACTIVE |
| SFSpringfield Feed Plant | Springfield | MO | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| SHSpringfield HQ HQ2 | Springfield | OH | Machinery Manufacturing333923 | 100-499 | ◐ LIKELY ACTIVE |
| SISpringfield IDEMIA Civil Identity | Springfield | IL | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| SKSpringfield Kuhns Plant 171 | Springfield | OH | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| SMSpringfield, MA | Springfield | MA | Food Manufacturing311612 | 100-499 | ◐ LIKELY ACTIVE |
| SMSpringfield Mill | Springfield | OR | Paper Manufacturing322130 | 100-499 | ◐ LIKELY ACTIVE |
| SOSpringfield, OR | Springfield | OR | Miscellaneous Manufacturing339999 | 1-19 | ◐ LIKELY ACTIVE |
| SPSpringfield Plant | Springfield | TN | Fabricated Metal Product Manufacturing332618 | 20-99 | ◐ LIKELY ACTIVE |
| SPSpringfield Plywood | Springfield | OR | Wood Product Manufacturing321212 | 100-499 | ◐ LIKELY ACTIVE |
| SPSpringfield POD HQ3 | Springfield | OH | Machinery Manufacturing333923 | 20-99 | ◐ LIKELY ACTIVE |