| KRKoppers Rock Hill | Rock Hill | SC | Chemical Manufacturing325180 | 20-99 | ◐ LIKELY ACTIVE |
| LLanxess | Charleston | SC | Chemical Manufacturing325199 | 20-99 | ◐ LIKELY ACTIVE |
| LCLanxess Coropration - Bushy Park Site | Goose Creek | SC | Chemical Manufacturing325199 | 20-99 | ◐ LIKELY ACTIVE |
| MLMk Lovett Originals LLC | Trenton | SC | Chemical Manufacturing325620 | — | ◐ LIKELY ACTIVE |
| NPNephron Pharmaceutical | West Columbia SC | SC | Chemical Manufacturing325412 | 500+ | ◐ LIKELY ACTIVE |
| NCNorth Charleston Branch 48 | North Charleston | SC | Chemical Manufacturing325120 | 1-19 | ◐ LIKELY ACTIVE |
| NLNutramax Laboratories Inc. | Lancaster | SC | Chemical Manufacturing325411 | 500+ | ◐ LIKELY ACTIVE |
| NLNutramax Laboratories Inc. Building 3 | Lancaster | SC | Chemical Manufacturing325411 | 100-499 | ◐ LIKELY ACTIVE |
| NLNutramax Laboratories Inc. Building 4 | Indian Land | SC | Chemical Manufacturing325411 | 20-99 | ◐ LIKELY ACTIVE |
| OPOrtec - Pendleton | Pendleton | SC | Chemical Manufacturing325199 | 20-99 | ◐ LIKELY ACTIVE |
| PIPalmetto Isotopes, LLC | Ridgeland | SC | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| PAPatheon API, Inc. | Florence | SC | Chemical Manufacturing325411 | 100-499 | ◐ LIKELY ACTIVE |
| PVPatriot Veteran Associates Pharma, LLC | Longs | SC | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| P7Plant 78 | Aiken | SC | Chemical Manufacturing325220 | 500+ | ◐ LIKELY ACTIVE |
| P8Plant 8S | Columbia | SC | Chemical Manufacturing325220 | 100-499 | ◐ LIKELY ACTIVE |
| PPPurAqua Products Inc. | Rock Hill | SC | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| PPPurple Power | Greer | SC | Chemical Manufacturing325611 | 20-99 | ◐ LIKELY ACTIVE |
| PAPVS Acquisition Inc. | West Union | SC | Chemical Manufacturing325199 | 20-99 | ◐ LIKELY ACTIVE |
| RCRe:build Cr, LLC | Rock Hill | SC | Chemical Manufacturing325211 | — | ◐ LIKELY ACTIVE |
| RHRock Hill Branch 50 | Rock Hill | SC | Chemical Manufacturing325120 | 1-19 | ◐ LIKELY ACTIVE |
| RGRoyal Gold Anderson | Anderson | SC | Chemical Manufacturing325314 | 1-19 | ◐ LIKELY ACTIVE |
| SASealed Air Medical | Duncan | SC | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| SJSmith & Jones Janitorial Supplies & Equipment INC | West Columbia | SC | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| SRSouthern Roots Herb Farm LLC | Winnsboro | SC | Chemical Manufacturing325611 | — | ◐ LIKELY ACTIVE |
| SPSterling Precision Machining, INC | Summerville | SC | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
Sun Chemical | N Charleston | SC | Chemical Manufacturing325510 | 20-99 | ◐ LIKELY ACTIVE |
| SUSyensqo USA LLC - Spartanburg Site | Spartanburg | SC | Chemical Manufacturing325613 | 20-99 | ◐ LIKELY ACTIVE |
| THTalicia Holdings, INC. | Duncan | SC | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| TSThe Scotts Company - Chester | Chester | SC | Chemical Manufacturing325314 | 20-99 | ◐ LIKELY ACTIVE |
| T5Thorne 558 Omni | Summeville | SC | Chemical Manufacturing325411 | 100-499 | ◐ LIKELY ACTIVE |
| TCToray CMA Spartanburg SC | Moore | SC | Chemical Manufacturing325220 | 100-499 | ◐ LIKELY ACTIVE |
| USUSA SC Chester Plant | Chester | SC | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| VEVictory Exofibres, LLC | Central | SC | Chemical Manufacturing325413 | — | ◐ LIKELY ACTIVE |
| GSGreentex Solutions, LLC | Charleston | SC | Chemical Manufacturing325315 | — | ◐ LIKELY ACTIVE |
| ALAbbott Laboratories-closed | Kingstree | SC | Chemical Manufacturing325412 | — | ◇ UNVERIFIED |
| APAir Products and Chemicals Inc-j.p. Stevens Piedmont Site-remediation Project | Piedmont | SC | Chemical Manufacturing325199 | — | ◇ UNVERIFIED |
| ACAlcami Corporation Clements Crest Warehouse | Charleston | SC | Chemical Manufacturing325411 | — | ◇ UNVERIFIED |
| AIAllnex INC | Beech Island | SC | Chemical Manufacturing325211 | — | ◇ UNVERIFIED |
| AMAmerican Marble Products INC. | Conway | SC | Chemical Manufacturing325991 | — | ◇ UNVERIFIED |
| ACApex Coating INC | Inman | SC | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
| APAscend Performance Materials Operations LLC | Greenwood | SC | Chemical Manufacturing325222 | — | ◇ UNVERIFIED |
| AFAscent Five, LLC | Travelers Rest | SC | Chemical Manufacturing325411 | — | ◇ UNVERIFIED |
| BCBasf CORP Mauldin Plant | Mauldin | SC | Chemical Manufacturing325613 | — | ◇ UNVERIFIED |
| BCBasf Corporation | Central | SC | Chemical Manufacturing325211 | — | ◇ UNVERIFIED |
| BCBasf Corporation @ Ethox Corporation | Greenville | SC | Chemical Manufacturing325199 | — | ◇ UNVERIFIED |
| BNBethune Nonwovens INC | Bethune | SC | Textile Mills313230 | — | ◇ UNVERIFIED |
| BIByo-Gon, Inc. | Wando | SC | Chemical Manufacturing325314 | — | ◇ UNVERIFIED |
| CCChase Corporation | Greenville | SC | Chemical Manufacturing325998 | — | ◇ UNVERIFIED |
| CSChemtrade Solutions LLC | Catawba | SC | Chemical Manufacturing325199 | — | ◇ UNVERIFIED |
| COCity of Greenville | Greenville | SC | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |