| BHBVC - Huron | Huron | SD | Food Manufacturing311613 | 1-19 | ◐ LIKELY ACTIVE |
| CHCCL Healthcare | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| CLCCL Label SF1 | Sioux Falls | SD | Printing and Related Support Activities323111 | 100-499 | ◐ LIKELY ACTIVE |
| CSChateau Sylvania Vineyard and Winery | Toronto | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CDChemistry Distilling, LLC | Rapid City | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CRCheyenne River Sioux Tribe Buffalo Authority CORP | Gettysburg | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| CEChrisamarie Estates Vineyard & Winery | Pierre | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CCCohort Craft Brewery | Rapid City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CLContraband LLC | Rapid City | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| CWConverse Wine Company | Arlington | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CPCorrugated Packaging Sioux Falls CT | Sioux Falls | SD | Paper Manufacturing322211 | 100-499 | ◐ LIKELY ACTIVE |
| CLCoteau Lakes Winery LLC | Clear Lake | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| CFCounterpart Fabrication | Brookings | SD | Fabricated Metal Product Manufacturing332322 | 20-99 | ◐ LIKELY ACTIVE |
| CSCreative Surfaces of the Black Hills | Rapid City | SD | Furniture and Related Product Manufacturing337212 | 20-99 | ◐ LIKELY ACTIVE |
| CECrenlo Engineered Cabs | Watertwon | SD | Machinery Manufacturing333120 | 100-499 | ◐ LIKELY ACTIVE |
| CSC & S Griese, L.l.c | Pierre | SD | Fabricated Metal Product Manufacturing332322 | — | ◐ LIKELY ACTIVE |
| CTCustom Truck One Source - Elk Point | Elk Point | SD | Transportation Equipment Manufacturing336212 | 20-99 | ◐ LIKELY ACTIVE |
| CMCut Meat Creek Custom | Chancellor | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| DBDakota Butcher | Watertown | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| DFDakota Falls | Brandon | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power Aberdeen | Aberdeen | SD | Fabricated Metal Product Manufacturing332912 | 1-19 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power OEM | Sioux Falls | SD | Fabricated Metal Product Manufacturing332912 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power Rapid City | Rapid City | SD | Fabricated Metal Product Manufacturing332912 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Fluid Power SF | Sioux Falls | SD | Fabricated Metal Product Manufacturing332912 | 20-99 | ◐ LIKELY ACTIVE |
| DGDakota Gobblers, LLC | Huron | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| DFDakotaland Feeds Cavour | Cavour | SD | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| DFDakotaland Feeds Herreid | Herreid | SD | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| DFDakotaland Feeds Huron | Huron | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakotaland Feeds Kennebec | Kennebec | SD | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| DMDakotaland Manufacturing | Sioux Falls | SD | Fabricated Metal Product Manufacturing332216 | 100-499 | ◐ LIKELY ACTIVE |
| DPDakota Provisions, LLC | Huron | SD | Food Manufacturing311615 | — | ◐ LIKELY ACTIVE |
| DPDakota Provisions - West | Huron | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| DPDakota Pure Meats, LLC | Wood | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| DSDakota Sign CO | Rapid City | SD | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| DSDakota Style | Clark | SD | Food Manufacturing311911 | 20-99 | ◐ LIKELY ACTIVE |
| DSDakota Style Chips | Clark | SD | Food Manufacturing311919 | 1-19 | ◐ LIKELY ACTIVE |
| DTDakota Tom Sandwiches, Inc | Corsica | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| DTDakota Tube- Airport Drive location | Watertown | SD | Fabricated Metal Product Manufacturing332996 | 100-499 | ◐ LIKELY ACTIVE |
| DTDakota Tube Inc. - Pheasant Ridge location | Watertown | SD | Fabricated Metal Product Manufacturing332996 | 1-19 | ◐ LIKELY ACTIVE |
| DPDak Pak LLC | Woonsocket | SD | Chemical Manufacturing325412 | 20-99 | ◐ LIKELY ACTIVE |
| DZDay & Zimmermann Lone Star LLC | Yankton | SD | Fabricated Metal Product Manufacturing332992 | — | ◐ LIKELY ACTIVE |
| DDDeadwood Distillery, LLC | Deadwood | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| DFDesJarlais Farms | Sturgis | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| DDDohrman Design and Manufacturing LLC | Piedmont | SD | Fabricated Metal Product Manufacturing332323 | — | ◐ LIKELY ACTIVE |
| DRD & R Propane, INC. | Eagle Butte | SD | Chemical Manufacturing325120 | — | ◐ LIKELY ACTIVE |
| ESEast Side Jersey Dairy - Sioux Falls Operations | Sioux Falls | SD | Food Manufacturing311511 | 20-99 | ◐ LIKELY ACTIVE |
| ELElkton Locker and Grocery, Inc. | Elkton | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| EMEnertech Mitchell | Mitchell | SD | Machinery Manufacturing333415 | 20-99 | ◐ LIKELY ACTIVE |
| EPETRIA Products USA INC. | Mitchell | SD | Chemical Manufacturing325992 | 20-99 | ◐ LIKELY ACTIVE |
| FSFCP Sioux Falls | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |