| FEFermentation Experts USA LLC | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| FDFernson Distilling Co. | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FDFernson Distilling Co. | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| FWFeuillerat Welding, LLC | Rapid City | SD | Machinery Manufacturing333248 | — | ◐ LIKELY ACTIVE |
| FFFields Fish & Game LLC | De Smet | SD | Fabricated Metal Product Manufacturing332992 | — | ▲ REPORTED CLOSED |
| FYFiltration Yankton | Yankton | SD | Transportation Equipment Manufacturing336390 | 100-499 | ◐ LIKELY ACTIVE |
| FIFimco INC | North Sioux City | SD | Machinery Manufacturing333111 | — | ◐ LIKELY ACTIVE |
| FPFIMCO Plants | North Sioux City | SD | Machinery Manufacturing333111 | 100-499 | ◐ LIKELY ACTIVE |
| FSFinishWorks (Tea, SD) | Tea | SD | Chemical Manufacturing325510 | 1-19 | ◐ LIKELY ACTIVE |
| FSFirehouse Smokejumper Station | Hill City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FWFirehouse Wine Cellars | Rapid City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FMFirst Manufacturing, LLC - Humboldt | Humboldt | SD | Machinery Manufacturing333517 | 1-19 | ◐ LIKELY ACTIVE |
| FGFive Glass Winery & Vineyard | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| FIFlagshooter, Inc | Sioux Falls | SD | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
| FPForest Products Distributors, INC. | Rapid City | SD | Wood Product Manufacturing321113 | — | ◐ LIKELY ACTIVE |
| FFsdcp | Mitchell | SD | Nonmetallic Mineral Product Manufacturing327332 | 20-99 | ◐ LIKELY ACTIVE |
| FCFull Circle Ag | Britton | SD | Chemical Manufacturing325314 | — | ◐ LIKELY ACTIVE |
| FTFull Throttle Sloon Shine, LLC | Vale | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GDG&H Distributing | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326220 | 20-99 | ◐ LIKELY ACTIVE |
| GTGhost Town Winery | Watertown | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| GLGlacial Lakes Distillery and Brewhouse LLC | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GLGlacial Lakes Distillery, LLC | Watertown | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
Glacial Lakes Rubber & Plastics - Watertown | Watertown | SD | Plastics and Rubber Products Manufacturing326299 | 20-99 | ◐ LIKELY ACTIVE |
| GNGlanbia Nutritionals (NA) Inc. - Sioux Falls | Sioux Falls | SD | Food Manufacturing311211 | 20-99 | ◐ LIKELY ACTIVE |
| GPGrand Prairie Foods, Inc. | Sioux Falls | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| GPGrand Prairie Foods, Inc. | Sioux Falls | SD | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |
| HSHarrold, SD | Harrold | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| HIHarvard Integrations | Tea | SD | Fabricated Metal Product Manufacturing332311 | 100-499 | ◐ LIKELY ACTIVE |
| H2Helper 24, LTD | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326111 | — | ◐ LIKELY ACTIVE |
| HMHidewood Meats, INC. | Brandt | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| HPHigh Plains Metalworks LLC | Sturgis | SD | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| HMHillcrest Meats LLC | Garden City | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| HPHills Products Group, INC. | Rapid City | SD | Wood Product Manufacturing321114 | — | ◐ LIKELY ACTIVE |
| HIHorner Industries INC. | Rapid City | SD | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| HIHorton, Inc Britton | Britton | SD | Transportation Equipment Manufacturing336390 | 100-499 | ◐ LIKELY ACTIVE |
| HHHumble Hill Winery | Garretson | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| HWHuron Welding LLC | Huron | SD | Fabricated Metal Product Manufacturing332322 | — | ◐ LIKELY ACTIVE |
| ITImmutrix Therapeutics, INC. | Rapid City | SD | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| ILInsofast, LLC | Mitchell | SD | Plastics and Rubber Products Manufacturing326140 | — | ◐ LIKELY ACTIVE |
| JWJackson Winery and Vineyards, L.l.c. | Belle Fourche | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| JPJacobs Precision Welding, INC | Lead | SD | Fabricated Metal Product Manufacturing332312 | — | ◐ LIKELY ACTIVE |
| JKJeremiah Klein and Lisa Klein | Hill City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| JMJ Musil Winery LLC | Huron | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| JDJr Distributing INC | Lake Norden | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| KPKamps Pallets - Sioux Falls | Sioux Falls | SD | Wood Product Manufacturing321920 | 1-19 | ◐ LIKELY ACTIVE |
| KPKing's Pasties | Lead | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| KGKlogo Group, INC | Sioux Falls | SD | Apparel Manufacturing315990 | — | ◐ LIKELY ACTIVE |
| LMLarson Mfg. LLC | Brookings | SD | Fabricated Metal Product Manufacturing332321 | 100-499 | ◐ LIKELY ACTIVE |
| LWLaughing Waters, INC. | Hartford | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| LVLebruce Vineyard and Winery | Bruce | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |