| QCQuality Custom Meats, LLC | Howard | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RPRainbow Play Systems, Inc. | Brookings | SD | Miscellaneous Manufacturing339920 | 20-99 | ◐ LIKELY ACTIVE |
| RRapcp | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327332 | 20-99 | ◐ LIKELY ACTIVE |
| RCRapid City (1016) | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| RCRapid City, USA | Rapid City | SD | Computer and Electronic Product Manufacturing334511 | 20-99 | ◐ LIKELY ACTIVE |
| RPRapid Precision Mfg | Britton | SD | Fabricated Metal Product Manufacturing332710 | 20-99 | ◐ LIKELY ACTIVE |
| RHRaven HQ | Sioux Falls | SD | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| RMRaven Manufacturing | Sioux Falls | SD | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| RARed's All Natural, LLC. | North Sioux City | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RDRegional Dental Lab, LLC | Sioux Falls | SD | Miscellaneous Manufacturing339116 | — | ◐ LIKELY ACTIVE |
| RCRenner Corner Jerky | Renner | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RCRing Container Belle Fourche | Belle Fourche | SD | Plastics and Rubber Products Manufacturing326160 | 1-19 | ◐ LIKELY ACTIVE |
| RERing-neck Energy & Feed, LLC | Onida | SD | Chemical Manufacturing325193 | — | ◐ LIKELY ACTIVE |
| RRoscoe | Roscoe | SD | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| RCRosebud Concrete, INC. | Winner | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| RVRott Vineyards, INC. | Jefferson | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RPRoyal Plastics Inc. | Brookings | SD | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◐ LIKELY ACTIVE |
| RRsd | N. Sioux City | SD | Food Manufacturing311111 | 100-499 | ◐ LIKELY ACTIVE |
| SVSchade Vineyards | Volga | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SFSchiltz Foods, Inc. | Sisseton | SD | Food Manufacturing311615 | — | ◐ LIKELY ACTIVE |
| SDSchlosser Ditching & Plumbing INC | Timber Lake | SD | Machinery Manufacturing333120 | — | ◐ LIKELY ACTIVE |
| STSchuurmans, Terry | Avon | SD | Machinery Manufacturing333112 | — | ◐ LIKELY ACTIVE |
| SDSd02-dakt-south Dakota Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339950 | 100-499 | ◐ LIKELY ACTIVE |
SD Industries Mitchell | Mitchell | SD | Fabricated Metal Product Manufacturing332313 | 1-19 | ◐ LIKELY ACTIVE |
| SBSecond Breakfast Enterprises, LLC | Aurora | SD | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |
| SLSenproco, LLC | Sioux Falls | SD | Chemical Manufacturing325611 | 20-99 | ◐ LIKELY ACTIVE |
| SLSentry LLC Watertown | Watertown | SD | Transportation Equipment Manufacturing336214 | 100-499 | ◐ LIKELY ACTIVE |
| SLShur-Co, LLC. | Yankton | SD | Textile Product Mills314910 | 100-499 | ◐ LIKELY ACTIVE |
| SCSimon - Custer Ready Mix | Custer | SD | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| SHSimon Hot Springs Ready Mix | Hot Springs | SD | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| SRSimon - Rapid City Concrete Plant | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| SFSioux Falls Admin Office | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Kitchen & Bath | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 100-499 | ◐ LIKELY ACTIVE |
| SFSioux Falls Location | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Regional Bakery - Main Store | Sioux Falls | SD | Food Manufacturing311812 | 20-99 | ◐ LIKELY ACTIVE |
| SSSioux Steel Livestock | Lennox | SD | Machinery Manufacturing333111 | 20-99 | ◐ LIKELY ACTIVE |
| SFSmithfield Foods | Sioux Falls | SD | Food Manufacturing311611 | 500+ | ◐ LIKELY ACTIVE |
| SGSolmax Geosynthetics,LLC | Spearfish | SD | Plastics and Rubber Products Manufacturing326113 | 1-19 | ◐ LIKELY ACTIVE |
| SDSouth Dakota | Brandon | SD | Miscellaneous Manufacturing339930 | 1-19 | ◐ LIKELY ACTIVE |
| SBSpartan - Brandon | Brandon | SD | Transportation Equipment Manufacturing336120 | 100-499 | ◐ LIKELY ACTIVE |
| SFSpartan Fire, LLC | Brandon | SD | Transportation Equipment Manufacturing336120 | — | ◐ LIKELY ACTIVE |
| SSSRAM - Spearfish | Spearfish | SD | Transportation Equipment Manufacturing336991 | 20-99 | ◐ LIKELY ACTIVE |
| SOStern Oil Company, INC | Freeman | SD | Petroleum and Coal Products Manufacturing324199 | — | ◐ LIKELY ACTIVE |
| S1Still 173, LLC | Vermillion | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SFStone Faces Distillery | Vermillion | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SFStone Faces Winery | Hill City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SSStonemeadow Springs Winery | Custer | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SWStrawbale Winery | Renner | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SMSturgis Meats LLC | Sturgis | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
Sturgis Meats LLC | Custer | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |