| SGSi Group INC - Orangeburg Facility | Orangeburg | SC | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| SSSilfab Solar | Fort Mill | SC | Computer and Electronic Product Manufacturing334413 | — | ◐ LIKELY ACTIVE |
| SBSims Bark CO of Georgia LLC | Bowman | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| SASix and Twenty Distillery, LLC | Piedmont | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SCSloan Construction:pacolet | Pacolet | SC | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
Smith-Midland Corporation (South Carolina) | Hopkins | SC | Nonmetallic Mineral Product Manufacturing327331 | 20-99 | ◐ LIKELY ACTIVE |
| STSnider Tire INC Dba Snider Fleet Solutions | Pelzer | SC | Plastics and Rubber Products Manufacturing326212 | — | ◐ LIKELY ACTIVE |
| SGSolmax Geosynthetics, Kingstree | Kingstree | SC | Textile Mills313110 | 20-99 | ◐ LIKELY ACTIVE |
| SISOPAKCO, Inc. | Mullins | SC | — | — | ◐ LIKELY ACTIVE |
| SCSoutheastern Concrete Products Columbia | Columbia | SC | Nonmetallic Mineral Product Manufacturing327331 | 1-19 | ◐ LIKELY ACTIVE |
| SPSoutheastern Products INC | Fountain Inn | SC | Wood Product Manufacturing321911 | 100-499 | ◐ LIKELY ACTIVE |
| SPSpan Packaging Services LLC Dba Multipac | Greenville | SC | Chemical Manufacturing325412 | — | ◐ LIKELY ACTIVE |
| SVSpecialty Vermiculite CORP | Enoree | SC | Nonmetallic Mineral Product Manufacturing327992 | — | ◐ LIKELY ACTIVE |
| S6Spencer 612 Florida, LLC | Easley | SC | Textile Mills313210 | — | ◐ LIKELY ACTIVE |
| SSSpirax Sarco Incorporated | Blythewood | SC | Fabricated Metal Product Manufacturing332911 | — | ◐ LIKELY ACTIVE |
| SCSrm - Charleston #706 | Johns Island | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| SGSrm - Goose Creek #707 | Goose Creek | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| SOSteelworks of the Carolinas, INC. | Piedmont | SC | Fabricated Metal Product Manufacturing332312 | — | ◐ LIKELY ACTIVE |
| SCSterilite Corporation CSC | Clinton | SC | Plastics and Rubber Products Manufacturing326199 | 100-499 | ◐ LIKELY ACTIVE |
| SCSummers Concrete Contracting, INC. Plant 450 | Kinston | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| SUSundaram-clayton USA LLC | Ridgeville | SC | Primary Metal Manufacturing331523 | 100-499 | ◐ LIKELY ACTIVE |
| SKSwiss Krono USA, Inc | Barnwell | SC | Wood Product Manufacturing321219 | 100-499 | ◐ LIKELY ACTIVE |
| TATegrant Alloyd Brands INC Gw Remediation | Spartanburg | SC | Paper Manufacturing322299 | — | ◐ LIKELY ACTIVE |
| TBThe Bernard Group | Duncan | SC | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| TBThe Boeing Company | Orangeburg | SC | Transportation Equipment Manufacturing336413 | — | ◐ LIKELY ACTIVE |
| TSThe Sefa Group INC - Mcmeekin Station | Columbia | SC | Nonmetallic Mineral Product Manufacturing327310 | — | ◐ LIKELY ACTIVE |
| TUThe Urban Electric Company | North Charleston | SC | Electrical Equipment, Appliance & Component Manufacturing335121 | 100-499 | ◐ LIKELY ACTIVE |
| TUThe Urban Electric Company - Arc | Charleston | SC | Electrical Equipment, Appliance & Component Manufacturing335131 | — | ◐ LIKELY ACTIVE |
| TCThomas Concrete of South Carolina - Cowpens | Cowpens | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| TCThomas Concrete of South Carolina INC Summerville | Summerville | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| TCTimken - Clinton Plant | Clinton | SC | Fabricated Metal Product Manufacturing332991 | — | ◐ LIKELY ACTIVE |
| TITranter Incorporated | Edgefield | SC | Fabricated Metal Product Manufacturing332313 | — | ◐ LIKELY ACTIVE |
| T3Twelve 33 Distillery, LLC | Little River | SC | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| UFUS Fibers | Trenton | SC | Chemical Manufacturing325220 | 100-499 | ◐ LIKELY ACTIVE |
| VUValagro USA Manufacturing | Orangeburg | SC | Chemical Manufacturing325314 | 1-19 | ◐ LIKELY ACTIVE |
| VIValmet INC | Aiken | SC | Textile Mills313320 | — | ◐ LIKELY ACTIVE |
| VIVanguard Industries Teflon Division Plant Ii | Anderson | SC | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| VSVan Smith Concrete:#5 | Goose Creek | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| VSVan Smith Concrete Company - Clements Ferry Plant | Charleston | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| VBVm Buyer Llc/mcnamee Mine | Bath | SC | Nonmetallic Mineral Product Manufacturing327992 | — | ◐ LIKELY ACTIVE |
| VPVtl Precision INC | Goose Creek | SC | Transportation Equipment Manufacturing336310 | 20-99 | ◐ LIKELY ACTIVE |
| VMVulcan Materials:columbia Quarry | Columbia | SC | Nonmetallic Mineral Product Manufacturing327331 | — | ◐ LIKELY ACTIVE |
| WWWaccamaw Wheel Williams-closed | Loris | SC | Plastics and Rubber Products Manufacturing326211 | — | ◐ LIKELY ACTIVE |
| WCWikoff Color CORP | Fort Mill | SC | Chemical Manufacturing325910 | — | ◐ LIKELY ACTIVE |
| WMWolfe Mechanical and Equipment CO INC | Lugoff | SC | Fabricated Metal Product Manufacturing332420 | 20-99 | ◐ LIKELY ACTIVE |
| ZCZeus Company Llc-aiken Facility | Aiken | SC | Plastics and Rubber Products Manufacturing326121 | — | ◐ LIKELY ACTIVE |
| 4S48forty Solutions - Grey Court Facility | Gray Court | SC | Wood Product Manufacturing321920 | — | ◐ LIKELY ACTIVE |
| 7F71007 - Frazier Industrial Company | Lamar | SC | Furniture and Related Product Manufacturing337127 | — | ◐ LIKELY ACTIVE |
| 7D72130 - Delavan Spray Technologies LLC | Bamberg | SC | Fabricated Metal Product Manufacturing332919 | — | ◐ LIKELY ACTIVE |
| 7P72251 - Plastic Omnium Auto Exterior LLC | Anderson | SC | Plastics and Rubber Products Manufacturing326199 | — | ◐ LIKELY ACTIVE |