| WIWild Idea Buffalo Suppliers | Hermosa | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| WTWilson Trailer Lennox | Lennox | SD | Transportation Equipment Manufacturing336212 | 100-499 | ◐ LIKELY ACTIVE |
| WCWin Chill Cold Storage, LLC | Sioux Falls | SD | — | — | ◐ LIKELY ACTIVE |
| WHWinery Hill City, LLC | Hill City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| WCWise Cat | Sturgis | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| WTWith the Wind Winery | Rosholt | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| WPWL Plastics - Rapid City | Rapid City | SD | Plastics and Rubber Products Manufacturing326122 | 20-99 | ◐ LIKELY ACTIVE |
| WEWurth Electronics Midcom Inc. | Watertown | SD | Computer and Electronic Product Manufacturing334416 | 100-499 | ◐ LIKELY ACTIVE |
| ZIZendeavor Interplanetary, LLC | Owanka | SD | Transportation Equipment Manufacturing336414 | — | ◐ LIKELY ACTIVE |
| ZBZymurcracy Beer Company | Rapid City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| ADAirborne Dynamic Systems, LLC | Midland | SD | Transportation Equipment Manufacturing336411 | — | ◐ LIKELY ACTIVE |
| CHCamrose Hutterian Brethren, INC | Frankfort | SD | Primary Metal Manufacturing331210 | — | ◐ LIKELY ACTIVE |
| CRCheyenne River Sioux Tribe Buffalo Authority CORP | Gettysburg | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| FCFull Circle Ag | Britton | SD | Chemical Manufacturing325314 | — | ◐ LIKELY ACTIVE |
| PSPierre Steel Mfg. LLC | Pierre | SD | Fabricated Metal Product Manufacturing332322 | — | ◐ LIKELY ACTIVE |
| PSPonderosa Services, INC | Mitchell | SD | Transportation Equipment Manufacturing336999 | — | ◐ LIKELY ACTIVE |
| TETorres Enterprises LLC | Rapid City | SD | Printing and Related Support Activities323113 | — | ◐ LIKELY ACTIVE |
| AJA-1 Jet, L.L.C. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332710 | 1-19 | ◇ UNVERIFIED |
| APAcme Pallet, INC. | Box Elder | SD | Wood Product Manufacturing321920 | 1-19 | ◇ UNVERIFIED |
| AGAVPRO Global Holdings LLC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334419 | 20-99 | ◇ UNVERIFIED |
| BFBranson Family Holdings LLC | Rapid City | SD | Primary Metal Manufacturing331210 | 20-99 | ◇ UNVERIFIED |
| BRBuffalo Ridge Brewing Project, LLC | Hartford | SD | Beverage and Tobacco Product Manufacturing312120 | 1-19 | ◇ UNVERIFIED |
| BCBullseye Custom Cabinetry, Inc. | Sioux falls | SD | Furniture and Related Product Manufacturing337122 | 20-99 | ◇ UNVERIFIED |
| CPClark Printing, LLC | Spearfish | SD | Printing and Related Support Activities323116 | 1-19 | ◇ UNVERIFIED |
| CSCommon Sense Manufacturing, Inc. | Faulkton | SD | Machinery Manufacturing333111 | 1-19 | ◇ UNVERIFIED |
| CMCreative Metal Solutions, Inc. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332312 | 1-19 | ◇ UNVERIFIED |
| CPCreative Printing, Inc. | Huron | SD | Printing and Related Support Activities323111 | 1-19 | ◇ UNVERIFIED |
| CPCrow Peak Brewing Company LLC. | Spearfish | SD | Beverage and Tobacco Product Manufacturing312120 | 1-19 | ◇ UNVERIFIED |
| CPCtrl P, LLC | Sioux Falls | SD | Printing and Related Support Activities323111 | 1-19 | ◇ UNVERIFIED |
| DIDakota International, Inc | Aberdeen | SD | Machinery Manufacturing333411 | 1-19 | ◇ UNVERIFIED |
| DSDakota Splash, INC. | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312112 | 1-19 | ◇ UNVERIFIED |
| DWDakota Western Corporation | Sisseton | SD | Plastics and Rubber Products Manufacturing326199 | 20-99 | ◇ UNVERIFIED |
| EBEdwin Besestre | Sioux Falls | SD | Food Manufacturing311813 | 1-19 | ◇ UNVERIFIED |
| EMEnclose Manufacturing, Inc. | Mitchell | SD | Fabricated Metal Product Manufacturing332999 | 1-19 | ◇ UNVERIFIED |
| FSFour Star Plastics INC | Aberdeen | SD | Plastics and Rubber Products Manufacturing326199 | 1-19 | ◇ UNVERIFIED |
| GBGroomers Best, INC. | Brandon | SD | Fabricated Metal Product Manufacturing332999 | 1-19 | ◇ UNVERIFIED |
| HPHigh Performance Engineering Inc. | Sioux Falls | SD | Machinery Manufacturing333511 | 1-19 | ◇ UNVERIFIED |
| HCHoward Cold Storage, INC. | Howard | SD | Food Manufacturing311612 | 1-19 | ◇ UNVERIFIED |
| JWJackson Winery and Vineyards LLC | Sturgis | SD | Beverage and Tobacco Product Manufacturing312130 | 1-19 | ◇ UNVERIFIED |
| KPK & P LLC | Rapid City | SD | Beverage and Tobacco Product Manufacturing312120 | 1-19 | ◇ UNVERIFIED |
| LILemmonMade, Inc. | Lemmon | SD | Food Manufacturing311612 | 1-19 | ◇ UNVERIFIED |
| LJL J Industries INC | Sioux Falls | SD | Machinery Manufacturing333992 | 1-19 | ◇ UNVERIFIED |
| MMMidwest Metal Works, Inc. | Canton | SD | Fabricated Metal Product Manufacturing332710 | 1-19 | ◇ UNVERIFIED |
| MTMtr Technologies, INC. | Brookings | SD | Computer and Electronic Product Manufacturing334419 | 1-19 | ◇ UNVERIFIED |
| MPMueller Pallets LLC | Sioux Falls | SD | Wood Product Manufacturing321920 | 20-99 | ◇ UNVERIFIED |
| NRN Rich Plant Food & Fertilizer, Inc. | Humboldt | SD | Chemical Manufacturing325314 | 1-19 | ◇ UNVERIFIED |
| NNutraferma | North Sioux City | SD | Food Manufacturing311119 | 1-19 | ◇ UNVERIFIED |
| OIOctane Ink, LLC | Tea | SD | Printing and Related Support Activities323113 | 1-19 | ◇ UNVERIFIED |
| OSOEM Solutions Inc | Rapid City | SD | Computer and Electronic Product Manufacturing334419 | 1-19 | ◇ UNVERIFIED |
| PPParkston Precision Machinery, LLC | Parkston | SD | Machinery Manufacturing333514 | 1-19 | ◇ UNVERIFIED |