| DADrive Automotive Industries of America INC. | Piedmont | SC | Transportation Equipment Manufacturing336370 | 500+ | ◐ LIKELY ACTIVE |
| ECEaton Corporation | North Charleston | SC | Fabricated Metal Product Manufacturing332912 | — | ◐ LIKELY ACTIVE |
Ehren Haus Industries INC | Fort Mill | SC | Plastics and Rubber Products Manufacturing326199 | — | ◐ LIKELY ACTIVE |
| EHElectrolux Home Prods | Anderson | SC | Electrical Equipment, Appliance & Component Manufacturing335220 | — | ◐ LIKELY ACTIVE |
| EEElement Electronics | Winnsboro | SC | Computer and Electronic Product Manufacturing334310 | 100-499 | ◐ LIKELY ACTIVE |
| ENEverris North America INC - North Charleston | N Charleston | SC | Food Manufacturing311942 | — | ◐ LIKELY ACTIVE |
| ECExecutive Cabinetry, LLC | Simpsonville | SC | Furniture and Related Product Manufacturing337110 | 100-499 | ◐ LIKELY ACTIVE |
| FUFinnchem USA - Eastover | Eastover | SC | Chemical Manufacturing325180 | — | ◐ LIKELY ACTIVE |
| FSFlame Spray North America INC | Fountain Inn | SC | Fabricated Metal Product Manufacturing332812 | 100-499 | ◐ LIKELY ACTIVE |
| FAFlextronics America, LLC | Orangeburg | SC | Fabricated Metal Product Manufacturing332212 | 500+ | ◐ LIKELY ACTIVE |
| FFloralife | Walterboro | SC | Chemical Manufacturing325998 | 20-99 | ◐ LIKELY ACTIVE |
| GGGe Gas Turbines (greenville) L.l.c. | Greenville | SC | Machinery Manufacturing333611 | — | ◐ LIKELY ACTIVE |
| GMGeorgetown Mill | Georgetown | SC | Paper Manufacturing322110 | — | ◐ LIKELY ACTIVE |
| GWGeorgia-pacific Wood Products LLC - Clarendon Osb | Alcolu | SC | Wood Product Manufacturing321219 | — | ◐ LIKELY ACTIVE |
| GKGold Kist Sumter Processing Plant | Sumter | SC | Food Manufacturing311613 | — | ◐ LIKELY ACTIVE |
| HPHalocarbon Prods CORP | North Augusta | SC | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| HPHi-tec Plating INC | Seneca | SC | Fabricated Metal Product Manufacturing332813 | 20-99 | ◐ LIKELY ACTIVE |
Holcim (us) INC. | Holly Hill | SC | Nonmetallic Mineral Product Manufacturing327310 | — | ◐ LIKELY ACTIVE |
| HSHoneywell Safety Products (north) | Clover | SC | Plastics and Rubber Products Manufacturing326299 | — | ◐ LIKELY ACTIVE |
| HSHoneywell Salisbury | Charleston | SC | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| HPHubbell Power Systems INC | Aiken | SC | Computer and Electronic Product Manufacturing334413 | — | ◐ LIKELY ACTIVE |
| HSHydra Sports Boats | Columbia | SC | Transportation Equipment Manufacturing336612 | — | ◐ LIKELY ACTIVE |
| IBIna Bearing CO INC | Cheraw | SC | Fabricated Metal Product Manufacturing332991 | — | ◐ LIKELY ACTIVE |
| ICInchem Corporation | Rock Hill | SC | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| ICIngevity Corporation Technical and Innovation Center | Charleston | SC | Chemical Manufacturing325191 | 100-499 | ◐ LIKELY ACTIVE |
| IAInman Asphalt Incorporated | Inman | SC | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| IGInterfor Georgetown Division | Georgetown | SC | Wood Product Manufacturing321113 | — | ◐ LIKELY ACTIVE |
| ISInternational Steel Group | Georgetown | SC | Nonmetallic Mineral Product Manufacturing327992 | — | ◐ LIKELY ACTIVE |
| ISInvista S.a.r.l. | Lugoff | SC | Chemical Manufacturing325211 | — | ◐ LIKELY ACTIVE |
| IMIrix Manufacturing Incorporated | Greenville | SC | Chemical Manufacturing325199 | — | ◐ LIKELY ACTIVE |
| IUIsola USA CORP | Ridgeway | SC | Plastics and Rubber Products Manufacturing326199 | — | ◐ LIKELY ACTIVE |
| JCJones-hamilton CO. | Richburg | SC | Chemical Manufacturing325180 | 20-99 | ◐ LIKELY ACTIVE |
| JNJTEKT North America | Blythewood | SC | Fabricated Metal Product Manufacturing332991 | 500+ | ◐ LIKELY ACTIVE |
| KEKemet Electronics Corporation | Simpsonville | SC | Computer and Electronic Product Manufacturing334414 | 100-499 | ◐ LIKELY ACTIVE |
Kenbay, LLC | Mount Pleasant | SC | Plastics and Rubber Products Manufacturing326199 | — | ◐ LIKELY ACTIVE |
| KWKey West Boats :summerville | Summerville | SC | Transportation Equipment Manufacturing336612 | — | ◐ LIKELY ACTIVE |
| KPKimberly-clark Palmetto | Beech Island | SC | Paper Manufacturing322120 | — | ◐ LIKELY ACTIVE |
| KRKnight Redi-mix Inc., - Plant 5 | North Charleston | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
Latin Collection, LLC | Charleston | SC | Apparel Manufacturing315120 | 1-19 | ◐ LIKELY ACTIVE |
| LPLeisure Pools and Spas Manufacturing North America INC | Marion | SC | Plastics and Rubber Products Manufacturing326199 | — | ◐ LIKELY ACTIVE |
| LCLindau Chemicals, INC. | Columbia | SC | Chemical Manufacturing325194 | 20-99 | ◐ LIKELY ACTIVE |
| LILsp Industrial Ceramics INC | Myrtle Beach | SC | Nonmetallic Mineral Product Manufacturing327110 | 1-19 | ◐ LIKELY ACTIVE |
| MSMagna Seating South Carolina | Moore | SC | Transportation Equipment Manufacturing336360 | 500+ | ◐ LIKELY ACTIVE |
| MPMarlboro Paper Mill | Bennettsville | SC | Paper Manufacturing322110 | — | ◐ LIKELY ACTIVE |
| MPMars Pet Care US INC Columbia | Columbia | SC | Food Manufacturing311111 | — | ◐ LIKELY ACTIVE |
| MFMccall Farms INC | Effingham | SC | Food Manufacturing311421 | — | ▲ REPORTED CLOSED |
Mclaughlin Body Company INC | Anderson | SC | Fabricated Metal Product Manufacturing332812 | 20-99 | ◐ LIKELY ACTIVE |
| MLMenardi LLC | Trenton | SC | Textile Product Mills314999 | 20-99 | ◐ LIKELY ACTIVE |
| MNMichelin North America INC - Spartanburg Facility (us3) | Spartanburg | SC | Plastics and Rubber Products Manufacturing326211 | — | ◐ LIKELY ACTIVE |
| MNMichelin North America INC Us10 | Anderson | SC | Plastics and Rubber Products Manufacturing326211 | — | ◐ LIKELY ACTIVE |