| MNMichelin North America, INC. -- Us2 | Sandy Springs | SC | Chemical Manufacturing325199 | — | ◐ LIKELY ACTIVE |
| MTMichelin Tweel Technologies | Piedmont | SC | Plastics and Rubber Products Manufacturing326211 | 20-99 | ◐ LIKELY ACTIVE |
| MTMichelin Tweel Technology | Piedmont | SC | Plastics and Rubber Products Manufacturing326211 | 20-99 | ◐ LIKELY ACTIVE |
| MCMiliken & Company Enterprise Plant | Marietta | SC | Textile Mills313210 | 100-499 | ◐ LIKELY ACTIVE |
| MCMilliken Chemical - Dewey Plant | Inman | SC | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| MSMita South Carolina Incorporated | Fountain Inn | SC | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| MCMitsubishi Chemical America, Performance Polymers | Greer | SC | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| NHNew Horizon Shutters International LLC | North Charleston | SC | Wood Product Manufacturing321911 | 1-19 | ◐ LIKELY ACTIVE |
| NCNexgen Composites LLC | Summerville | SC | Fabricated Metal Product Manufacturing332312 | 20-99 | ▲ REPORTED CLOSED |
| NUNicca USA INC | Fountain Inn | SC | Chemical Manufacturing325199 | 20-99 | ◐ LIKELY ACTIVE |
| NMNova Molecular Sumter LLC | Sumter | SC | Chemical Manufacturing325199 | 20-99 | ◐ LIKELY ACTIVE |
| NCNucor CORP - Darlington Plant | Darlington | SC | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| OBOldcastle Building Envelope | Rock Hill | SC | Nonmetallic Mineral Product Manufacturing327215 | 100-499 | ◐ LIKELY ACTIVE |
| OLOldcastle Lawn & Garden | Gaffney | SC | Wood Product Manufacturing321999 | — | ◐ LIKELY ACTIVE |
| OROrangeburg Redi Mix Concrete INC | Orangeburg | SC | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
Organic Dyes and Pigments | Union | SC | Chemical Manufacturing325130 | 1-19 | ◐ LIKELY ACTIVE |
| OPOrion Performance Compounds, INC. | Lugoff | SC | Chemical Manufacturing325211 | 1-19 | ◐ LIKELY ACTIVE |
| OCOwens Corning Composite Materials Ii, LLC | Starr | SC | Nonmetallic Mineral Product Manufacturing327212 | — | ◐ LIKELY ACTIVE |
| OLOxco, LLC | Fort Mill | SC | Textile Mills313310 | 20-99 | ◐ LIKELY ACTIVE |
Parimer Scientific LLC | Easley | SC | Chemical Manufacturing325199 | 1-19 | ◐ LIKELY ACTIVE |
| PUPierburg US LLC | Fountain Inn | SC | Fabricated Metal Product Manufacturing332116 | 100-499 | ◐ LIKELY ACTIVE |
| PMPol-tech Machining, LLC | Woodruff | SC | Fabricated Metal Product Manufacturing332710 | 1-19 | ▲ REPORTED CLOSED |
| PIPoly-med INC | Anderson | SC | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| PPPurAqua Products Inc. | Rock Hill | SC | Chemical Manufacturing325211 | 20-99 | ◐ LIKELY ACTIVE |
| QCQuikrete Construction Materials, LLC - Harleyville Cement Plant | Harleyville | SC | Nonmetallic Mineral Product Manufacturing327310 | — | ◐ LIKELY ACTIVE |
| RBRexam Beverage Can Company | Bishopville | SC | Fabricated Metal Product Manufacturing332431 | — | ◐ LIKELY ACTIVE |
| RIRhodia INC. - Charleston, Sc Plant | Charleston | SC | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| RIRhythmlink International LLC | Columbia | SC | Computer and Electronic Product Manufacturing334510 | 20-99 | ▲ REPORTED CLOSED |
| RORmax Operating LLC | Greer | SC | Plastics and Rubber Products Manufacturing326121 | — | ◐ LIKELY ACTIVE |
| RFRmf Facility Piedmont | Piedmont | SC | Fabricated Metal Product Manufacturing332813 | — | ◐ LIKELY ACTIVE |
| RBRobert Bosch LLC | Anderson | SC | Computer and Electronic Product Manufacturing334515 | 500+ | ◐ LIKELY ACTIVE |
Rohmann LLC | Spartanburg | SC | Computer and Electronic Product Manufacturing334519 | 1-19 | ◐ LIKELY ACTIVE |
| RFRoseburg Forest Products Chester Engineered Wood Products Facility | Chester | SC | Food Manufacturing311991 | — | ◐ LIKELY ACTIVE |
| RMRoy Metal Finishing RMF2 | Greenville | SC | Fabricated Metal Product Manufacturing332813 | 1-19 | ◐ LIKELY ACTIVE |
| SGSchaeffler Group USA INC - Plant I I | Cheraw | SC | Fabricated Metal Product Manufacturing332991 | 100-499 | ◐ LIKELY ACTIVE |
| SESchneider Electric | Seneca | SC | Electrical Equipment, Appliance & Component Manufacturing335314 | 500+ | ◐ LIKELY ACTIVE |
| SBScout Boats | Summerville | SC | Transportation Equipment Manufacturing336612 | — | ◐ LIKELY ACTIVE |
| SPSc Pet Food Solutions, LLC | Ward | SC | Food Manufacturing311111 | 100-499 | ◐ LIKELY ACTIVE |
| SESew Eurodrive Incorporated | Lyman | SC | Machinery Manufacturing333612 | 500+ | ◐ LIKELY ACTIVE |
| SIShaw Industries Group INC Plant 8s | Columbia | SC | Chemical Manufacturing325211 | — | ◐ LIKELY ACTIVE |
| SJSmi Joist:cayce | Cayce | SC | Fabricated Metal Product Manufacturing332312 | — | ◐ LIKELY ACTIVE |
| SUSolvay USA INC | Spartanburg | SC | Chemical Manufacturing325110 | — | ◐ LIKELY ACTIVE |
| SISopakco INC | Bennettsville | SC | Food Manufacturing311421 | 100-499 | ◐ LIKELY ACTIVE |
| SASouth Atlantic LLC Dba South Atlantic Ga | Laurens | SC | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| SCSoutheastern Concrete Products Upstate LLC | Simpsonville | SC | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| SISpecialty Industrial Products, INC. | Spartanburg | SC | Chemical Manufacturing325199 | — | ◐ LIKELY ACTIVE |
| SOSpecialty Oil Extractors | Darlington | SC | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| SSSpirax Sarco Incorporated | Blythewood | SC | Fabricated Metal Product Manufacturing332911 | 500+ | ◐ LIKELY ACTIVE |
| SOSp Orian LLC | Anderson | SC | Food Manufacturing311211 | 20-99 | ◐ LIKELY ACTIVE |
| SWStarchem -- Wellford Plant | Wellford | SC | Food Manufacturing311942 | — | ◐ LIKELY ACTIVE |