| SPSCC Properties, LLC | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| SESDR Enterprises Inc | Revillo | SD | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| SDSexauer Discount Farm Services, INC. | Brookings | SD | Food Manufacturing311119 | — | ◇ UNVERIFIED |
| SMSfkb Millwork | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | — | ◇ UNVERIFIED |
| SLSignature Lettering, LLC | Sioux Falls | SD | Printing and Related Support Activities323111 | — | ◇ UNVERIFIED |
| SOSlydog of South Dakota, Inc. | Madison | SD | Transportation Equipment Manufacturing336999 | — | ◇ UNVERIFIED |
| SFSmack Foods, INC. | Hurley | SD | Food Manufacturing311999 | — | ◇ UNVERIFIED |
| SSSmudge Studios LLC | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327110 | — | ◇ UNVERIFIED |
| SSSodak Soda LLC | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312111 | — | ◇ UNVERIFIED |
| SSState Steel of South Dakota, INC. | Sioux Falls | SD | Primary Metal Manufacturing331110 | — | ◇ UNVERIFIED |
| SBSturgis Brewing Company | Sturgis | SD | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| SMSturgis Meats LLC | Custer | SD | Food Manufacturing311611 | — | ◇ UNVERIFIED |
| SMSturgis Meats LLC | Rapid City | SD | Food Manufacturing311611 | — | ◇ UNVERIFIED |
| SDSunrise Dairy, LLC | Clear Lake | SD | Food Manufacturing311511 | — | ◇ UNVERIFIED |
| TAT and K Hunting Gear LLC | Rapid City | SD | Apparel Manufacturing315990 | — | ◇ UNVERIFIED |
| TCTerex Corporation | Canton | SD | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| TBThe Breaks Coffee Roasting Co | Sioux Falls | SD | Food Manufacturing311920 | — | ◇ UNVERIFIED |
 Thermo Bond Buildings, INC. | Elk Point | SD | Wood Product Manufacturing321992 | — | ◇ UNVERIFIED |
| TTTotally Tubular Mfg., INC. | Aberdeen | SD | Fabricated Metal Product Manufacturing332311 | — | ◇ UNVERIFIED |
| TWTroy's Wood Specialties, Inc. | Dell Rapids | SD | Furniture and Related Product Manufacturing337110 | — | ◇ UNVERIFIED |
 Truenorth Steel - Huron | Huron | SD | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| TCTwin City Fan Companies, LTD | Elkton | SD | Machinery Manufacturing333413 | — | ◇ UNVERIFIED |
| TSTwistedsage Studios, Inc. | Buffalo Gap | SD | Fabricated Metal Product Manufacturing332999 | — | ◇ UNVERIFIED |
| TSTwistedsage Studios, Inc. | Buffalo Gap | SD | Fabricated Metal Product Manufacturing332999 | — | ◇ UNVERIFIED |
| TGTwo Gals and a Guy LLC | Rapid City | SD | Food Manufacturing311811 | — | ◇ UNVERIFIED |
| VSVandyke Supply | Woonsocket | SD | Plastics and Rubber Products Manufacturing326150 | — | ◇ UNVERIFIED |
| VDVector Design Print and Tech LLC | Keystone | SD | Printing and Related Support Activities323111 | — | ◇ UNVERIFIED |
| VWVirg's Welding & Repair | Sioux Falls | SD | Machinery Manufacturing333992 | — | ◇ UNVERIFIED |
| VLV & L Manufacturing, Inc. | Tea | SD | Fabricated Metal Product Manufacturing332999 | — | ◇ UNVERIFIED |
| VMV&L Manufacturing, Inc. | Worthing | SD | Fabricated Metal Product Manufacturing332710 | — | ◇ UNVERIFIED |
| WMWall Medical, Inc. | Vermillion | SD | Miscellaneous Manufacturing339112 | — | ◇ UNVERIFIED |
| WLWeirwood LLC | Hartford | SD | Wood Product Manufacturing321999 | — | ◇ UNVERIFIED |
| WCWest Central Manufacturing | Rapid City | SD | Furniture and Related Product Manufacturing337215 | — | ◇ UNVERIFIED |
| WSWe Stitch Stuff, LLC | Sioux Falls | SD | Miscellaneous Manufacturing339112 | — | ◇ UNVERIFIED |
| WSWestrock Services, INC. | Sioux Falls | SD | Paper Manufacturing322211 | — | ◇ UNVERIFIED |
| WOWhispering Oaks, LLC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334310 | — | ◇ UNVERIFIED |
| WHWmmpa Hubbard Feed Mill and Adjoining Property | Watertown | SD | Food Manufacturing311119 | — | ◇ UNVERIFIED |
| XBXIX Brewing Company | Vermillion | SD | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| XBXIX Brewing Company, LLC | Vermillion | SD | Beverage and Tobacco Product Manufacturing312120 | — | ◇ UNVERIFIED |
| YWYNutz Wall One Inc | Sioux Falls | SD | Food Manufacturing311520 | — | ◇ UNVERIFIED |
