Wheeler Lumber L.l.c. | Whitewood | SD | Wood Product Manufacturing321114 | — | ◐ LIKELY ACTIVE |
| WTWilson Trailer Company | Yankton | SD | Transportation Equipment Manufacturing336212 | — | ◐ LIKELY ACTIVE |
| AAA & a Engraving INC | Rapid City | SD | Fabricated Metal Product Manufacturing332813 | 20-99 | ◐ LIKELY ACTIVE |
| AMAviation Manufacturing Group, LLC DBA The Freeman Company | Yankton | SD | Transportation Equipment Manufacturing336413 | 20-99 | ◐ LIKELY ACTIVE |
| BPBrookings-sd-falcon Plastics | Brookings | SD | Miscellaneous Manufacturing339113 | 1-19 | ◐ LIKELY ACTIVE |
| DFDakota Foundry, INC. | Webster | SD | Primary Metal Manufacturing331511 | 20-99 | ◐ LIKELY ACTIVE |
| ETEmpirical Technology | Dakota Dunes | SD | Food Manufacturing311611 | 500+ | ◐ LIKELY ACTIVE |
| JEJerry's Electric, INC | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | 20-99 | ◐ LIKELY ACTIVE |
| JDJr Distributing INC | Lake Norden | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| MMMds Manufacturing | Parkston | SD | Fabricated Metal Product Manufacturing332212 | 20-99 | ◐ LIKELY ACTIVE |
| NNNovita Nutrition, LLC | Brookings | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| PCPowdertech Corporation | Webster | SD | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| PSPreform Solutions, INC. | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
Sd Industries | Alexandria | SD | Primary Metal Manufacturing331210 | 20-99 | ◐ LIKELY ACTIVE |
| SWSupreme Welding, INC. | Clear Lake | SD | Fabricated Metal Product Manufacturing332312 | 1-19 | ◐ LIKELY ACTIVE |
| WSWatertown SD | Watertown | SD | Primary Metal Manufacturing331523 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Fiberglass INC | Webster | SD | Plastics and Rubber Products Manufacturing326199 | 1-19 | ◐ LIKELY ACTIVE |
| GAGcp Applied Technologies INC. @ Gage Brothers | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327390 | 100-499 | ◐ LIKELY ACTIVE |
| TRT & R Service Company | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | 1-19 | ◐ LIKELY ACTIVE |
| ARAce Ready Mix- Sioux Falls | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| BDBadlands Distillery LLC | Kadoka | SD | Beverage and Tobacco Product Manufacturing312140 | 1-19 | ◐ LIKELY ACTIVE |
| BTBaker Timber Products Inc. | Rapid City | SD | Wood Product Manufacturing321113 | 20-99 | ◐ LIKELY ACTIVE |
| BBBel Brands USA | Brookings | SD | Food Manufacturing311513 | 100-499 | ◐ LIKELY ACTIVE |
| BFBenchmark Foam (former) | Watertown | SD | Plastics and Rubber Products Manufacturing326140 | — | ◐ LIKELY ACTIVE |
| BHBlack Hills Ammunition INC | Rapid City | SD | Fabricated Metal Product Manufacturing332992 | — | ◐ LIKELY ACTIVE |
| CLCcl Label Modern Press Div | Sioux Falls | SD | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| COCitation Oil and Gas Corporation | Buffalo | SD | Machinery Manufacturing333132 | — | ◐ LIKELY ACTIVE |
| CRCrete Ready Foam LLC | Wessington Springs | SD | Plastics and Rubber Products Manufacturing326140 | — | ◐ LIKELY ACTIVE |
| DSDakota Style | Clark | SD | Food Manufacturing311911 | 20-99 | ◐ LIKELY ACTIVE |
| DPDak Pak LLC | Woonsocket | SD | Chemical Manufacturing325412 | 20-99 | ◐ LIKELY ACTIVE |
| DMDells Materials | Dell Rapids | SD | Nonmetallic Mineral Product Manufacturing327310 | 1-19 | ◐ LIKELY ACTIVE |
| ESEast Side Jersey Dairy - Sioux Falls Operations | Sioux Falls | SD | Food Manufacturing311511 | 20-99 | ◐ LIKELY ACTIVE |
| ETEngineered Truss Systems, INC. | Sioux Falls | SD | Wood Product Manufacturing321214 | 20-99 | ◐ LIKELY ACTIVE |
| FMFirst Manufacturing, LLC - Humboldt | Humboldt | SD | Machinery Manufacturing333517 | 1-19 | ◐ LIKELY ACTIVE |
| HRHeartland Repair & Coatings | Box Elder | SD | Fabricated Metal Product Manufacturing332420 | 1-19 | ◐ LIKELY ACTIVE |
| HPHigh Plains Processing, LLC (high Plains) | Mitchell, South Dakota | SD | Food Manufacturing311224 | — | ◐ LIKELY ACTIVE |
| HMHorizontal Machining & Mfg. Inc. | Huron | SD | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| HIHorner Industries INC. | Rapid City | SD | Fabricated Metal Product Manufacturing332999 | 1-19 | ◐ LIKELY ACTIVE |
| HEHuron Energy Llc, Dba Glacial Lakes Energy LLC | Huron | SD | Chemical Manufacturing325193 | — | ◐ LIKELY ACTIVE |
| HWHuron Welding LLC | Huron | SD | Fabricated Metal Product Manufacturing332322 | 1-19 | ◐ LIKELY ACTIVE |
| ISIdic Specialty Drilling Chemicals LLC | Belle Fourche | SD | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| KRKnife River | Parkston, City of | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| LLLanast LLC Dba Arctic Ice | North Sioux City | SD | Beverage and Tobacco Product Manufacturing312113 | — | ◐ LIKELY ACTIVE |
| LSLyle Signs INC | De Smet | SD | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| MMMajestic Medical LLC | Harrisburg | SD | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| MIMidcom INC | Aberdeen | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| MRMidwest Railcar Repair INC | Brandon | SD | Transportation Equipment Manufacturing336510 | — | ◐ LIKELY ACTIVE |
| PMPetersen Machine, LLC | Brandon | SD | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| PAPrairie AquaTech Manufacturing, LLC dba Houdek Manufacturing | Volga | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| PBPremier Bee LLC | Sioux Falls | SD | Wood Product Manufacturing321999 | 20-99 | ◐ LIKELY ACTIVE |