| CEChemring Energetic Devices | Clear Lake | SD | Chemical Manufacturing325920 | — | ◇ UNVERIFIED |
| CMConcrete Materials | Sioux Falls | SD | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| CMConcrete Materials Company | Yankton | SD | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| DTDakota Tube Building 3 | Watertown | SD | Primary Metal Manufacturing331210 | — | ◇ UNVERIFIED |
| DTDakota Tube INC | Watertown | SD | Fabricated Metal Product Manufacturing332813 | — | ◇ UNVERIFIED |
Daktronics, INC. | Sioux Falls | SD | Miscellaneous Manufacturing339950 | — | ◇ UNVERIFIED |
| FSFiberglass Specialties INC | Watertown | SD | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| HTHendrickson Trailer Suspension Systems | Mitchell | SD | Transportation Equipment Manufacturing336330 | — | ◇ UNVERIFIED |
| HPHills Products Group | Whitewood | SD | Wood Product Manufacturing321114 | — | ◇ UNVERIFIED |
| LTLuverne Truck Equipment INC | Brandon | SD | Fabricated Metal Product Manufacturing332119 | — | ◇ UNVERIFIED |
Raven Industries INC. (applied Technologies) | Sioux Falls | SD | Computer and Electronic Product Manufacturing334418 | — | ◇ UNVERIFIED |
| SESmith Equipment Manufacturing | Watertown | SD | Fabricated Metal Product Manufacturing332721 | — | ◇ UNVERIFIED |
| TTerex | Huron | SD | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| TLTerex Load King Div | Elk Point | SD | Transportation Equipment Manufacturing336211 | — | ◇ UNVERIFIED |
| TKTrail King Inds INC | Mitchell | SD | Transportation Equipment Manufacturing336212 | — | ◇ UNVERIFIED |
Twin City Die Castings CO - Watertown Div | Watertown | SD | Primary Metal Manufacturing331522 | — | ◇ UNVERIFIED |
| WCWalling Chemical Company | Sioux Falls | SD | Chemical Manufacturing325998 | — | ◇ UNVERIFIED |
Wheeler Lumber L.l.c. | Whitewood | SD | Wood Product Manufacturing321114 | — | ◇ UNVERIFIED |
| WTWilson Trailer Company | Yankton | SD | Transportation Equipment Manufacturing336212 | — | ◇ UNVERIFIED |
| PCPowdertech Corporation | Webster | SD | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| PSPreform Solutions, INC. | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
Rush CO INC | Springfield | SD | Textile Product Mills314910 | — | ◐ LIKELY ACTIVE |
| DCDegeest Corporation | Tea | SD | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| KMK-w Manufacturing | Sioux Falls | SD | Machinery Manufacturing333111 | — | ◇ UNVERIFIED |
| LMLucid Manufacturing Incorporated (former) | Mitchell | SD | Wood Product Manufacturing321999 | — | ◇ UNVERIFIED |
| MMMitchell Manufacturing, LLC | Mitchell | SD | Miscellaneous Manufacturing339920 | — | ◇ UNVERIFIED |
| OOverbuilt | Huron | SD | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| PPPure Pulp Products, INC. | Plankinton | SD | Paper Manufacturing322299 | — | ◇ UNVERIFIED |
| ARAce Ready Mix- Sioux Falls | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| BBBel Brands USA | Brookings | SD | Food Manufacturing311513 | 100-499 | ◐ LIKELY ACTIVE |
| BFBenchmark Foam (former) | Watertown | SD | Plastics and Rubber Products Manufacturing326140 | — | ◐ LIKELY ACTIVE |
| BHBlack Hills Ammunition INC | Rapid City | SD | Fabricated Metal Product Manufacturing332992 | — | ◐ LIKELY ACTIVE |
| CICardinal Industries, INC. | Aberdeen | SD | Plastics and Rubber Products Manufacturing326199 | — | ▲ REPORTED CLOSED |
| CLCcl Label Modern Press Div | Sioux Falls | SD | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| COCitation Oil and Gas Corporation | Buffalo | SD | Machinery Manufacturing333132 | — | ◐ LIKELY ACTIVE |
| CRCrete Ready Foam LLC | Wessington Springs | SD | Plastics and Rubber Products Manufacturing326140 | — | ◐ LIKELY ACTIVE |
| DFDakota Foundry, INC. | Webster | SD | Primary Metal Manufacturing331511 | — | ◐ LIKELY ACTIVE |
| DMDells Materials | Dell Rapids | SD | Nonmetallic Mineral Product Manufacturing327310 | 1-19 | ◐ LIKELY ACTIVE |
| ETEmpirical Technology | Dakota Dunes | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| ETEngineered Truss Systems, INC. | Sioux Falls | SD | Wood Product Manufacturing321214 | 20-99 | ◐ LIKELY ACTIVE |
| GBGage Bros. Concrete Products INC. | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327390 | — | ◐ LIKELY ACTIVE |
| HRHeartland Repair & Coatings | Box Elder | SD | Fabricated Metal Product Manufacturing332420 | 1-19 | ◐ LIKELY ACTIVE |
| HPHigh Plains Processing, LLC (high Plains) | Mitchell, South Dakota | SD | Food Manufacturing311224 | — | ◐ LIKELY ACTIVE |
| HMHorizontal Machining & Mfg. Inc. | Huron | SD | Fabricated Metal Product Manufacturing332312 | 20-99 | ◐ LIKELY ACTIVE |
| HCHub City Energy LLC | Aberdeen | SD | Chemical Manufacturing325193 | — | ◐ LIKELY ACTIVE |
| HEHuron Energy Llc, Dba Glacial Lakes Energy LLC | Huron | SD | Chemical Manufacturing325193 | — | ◐ LIKELY ACTIVE |
| HEHydro Extrusion Usa, LLC | Yankton | SD | Primary Metal Manufacturing331314 | — | ◐ LIKELY ACTIVE |
| ISIdic Specialty Drilling Chemicals LLC | Belle Fourche | SD | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| JEJerry's Electric, INC | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | — | ◐ LIKELY ACTIVE |
| KRKnife River | Parkston, City of | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |