| HTHutchinson Technology INC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334000 | — | ◇ UNVERIFIED |
| JIJebro INC | Brandon | SD | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| JRJensen Rock & Sand INC. | Aberdeen | SD | Nonmetallic Mineral Product Manufacturing327390 | — | ◇ UNVERIFIED |
| LOLand O'lakes Purina Feed LLC - Sioux Falls Sd | Sioux Falls | SD | Food Manufacturing311119 | — | ◇ UNVERIFIED |
| LSLittelfuse / Symcom | Rapid City | SD | Electrical Equipment, Appliance & Component Manufacturing335314 | — | ◇ UNVERIFIED |
| MLMetrix, LLC | Watertown | SD | Fabricated Metal Product Manufacturing332812 | — | ◇ UNVERIFIED |
| MFMeyerink Farm Service INC. | Platte | SD | Machinery Manufacturing333111 | — | ◇ UNVERIFIED |
| MIMidcom INC | Watertown | SD | Computer and Electronic Product Manufacturing334416 | — | ◇ UNVERIFIED |
| MRMidwest Ready Mix | Vermillion | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| MRMinnesota Rubber & Plastics | Watertown | SD | Plastics and Rubber Products Manufacturing326191 | — | ◇ UNVERIFIED |
| MCMitchell Concrete INC. | Mitchell | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| MFMolded Fiber Glass Companies | Aberdeen | SD | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| MFMolded Fiber Glass Companies | Aberdeen | SD | Plastics and Rubber Products Manufacturing326199 | — | ◇ UNVERIFIED |
| MSMorgan Sawmill | Pringle | SD | Wood Product Manufacturing321113 | — | ◇ UNVERIFIED |
| NENeiman Enterprises INC. D.b.a Rushmore Forest Products INC | Hill City | SD | Wood Product Manufacturing321113 | — | ◇ UNVERIFIED |
| NLNewberg Lumber Company, INC. | Custer | SD | Wood Product Manufacturing321113 | — | ◇ UNVERIFIED |
| PIPersona, INC. | Madison | SD | Printing and Related Support Activities323113 | — | ◇ UNVERIFIED |
| PIPolaris Industries, INC. Spearfish (former) | Spearfish | SD | Transportation Equipment Manufacturing336991 | — | ◇ UNVERIFIED |
 Raven Industries INC. | Sioux Falls | SD | Computer and Electronic Product Manufacturing334418 | — | ◇ UNVERIFIED |
| RGRiddles Group, INC. | Rapid City | SD | Miscellaneous Manufacturing339911 | — | ◇ UNVERIFIED |
| RCRosebud Concrete INC | Mission | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| SCSaputo Cheese USA INC | Big Stone City | SD | Food Manufacturing311513 | — | ◇ UNVERIFIED |
| SSSd Soybean Processors - Miller Facility | Saint Lawrence | SD | Food Manufacturing311224 | — | ◇ UNVERIFIED |
| SCSolomon Corporation - Flandreau | Flandreau | SD | Fabricated Metal Product Manufacturing332999 | — | ◇ UNVERIFIED |
| SDSouth Dakota Soybean Processors - St. Lawrence | Miller | SD | Food Manufacturing311224 | — | ◇ UNVERIFIED |
| SESpartan Erv | Brandon | SD | Transportation Equipment Manufacturing336211 | — | ◇ UNVERIFIED |
| SESpartan Erv | Brandon | SD | Machinery Manufacturing333924 | — | ◇ UNVERIFIED |
| SMSpecialty Manufacturing Company INC. | Bath | SD | Machinery Manufacturing333111 | — | ◇ UNVERIFIED |
| SCSweetman Const. CO. - Corson Complex | Brandon | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| SCSweetman Const. CO. - E. Rice St. Distribution Complex | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| SCSweetman Const. CO. - W. Madison St. Complex | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| TSTcc - Sioux Falls | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| TSTerex South Dakota | Watertown | SD | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| TSTerex South Dakota - Main Plant | Watertown | SD | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| TPTops Products Beresford | Beresford | SD | Paper Manufacturing322230 | — | ◇ UNVERIFIED |
| TAToshiba America Information Systems Incorporated Toner Products Division | Mitchell | SD | Chemical Manufacturing325992 | — | ◇ UNVERIFIED |
| TKTrail King Industries | Yankton | SD | Transportation Equipment Manufacturing336212 | — | ◇ UNVERIFIED |
| TKTrail King Industries | Yankton | SD | Transportation Equipment Manufacturing336212 | — | ◇ UNVERIFIED |
| TCTwin City Fan Companies LTD - Brookings Plant | Brookings | SD | Machinery Manufacturing333413 | — | ◇ UNVERIFIED |
| UAUltramax Ammunition | Rapid City | SD | Fabricated Metal Product Manufacturing332993 | — | ◇ UNVERIFIED |
| UCUnited Concrete | Harrisburg | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| VIViaflex, INC. | Brandon | SD | Plastics and Rubber Products Manufacturing326113 | — | ◇ UNVERIFIED |
| WMWheeler Manufacturing Co, INC. | Lemmon | SD | Miscellaneous Manufacturing339911 | — | ◇ UNVERIFIED |
| WIWinter, INC. | Brookings | SD | Nonmetallic Mineral Product Manufacturing327390 | — | ◇ UNVERIFIED |
| WIWinter, INC. | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327390 | — | ◇ UNVERIFIED |
| WEWoods Equipment CO | Sioux Falls | SD | Machinery Manufacturing333111 | — | ◇ UNVERIFIED |
| YCYankton, City of | Yankton | SD | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| 2C21st Century Mfg. | Lake Preston | SD | Machinery Manufacturing333515 | 20-99 | ◐ LIKELY ACTIVE |
| DP"4083 - Dakota Panel Pick and Assembly" | Rapid City | SD | Wood Product Manufacturing321212 | 20-99 | ◐ LIKELY ACTIVE |
| AAberdeen | Aberdeen | SD | Textile Mills313230 | 500+ | ◐ LIKELY ACTIVE |
